Dr Kimme Hyrich MD PhD FRCPC

Photograph of Kimme Hyrich

Reader in Rheumatic Disease Epidemiology

Arthritis Research UK Centre for Epidemiology
Centre for Musculoskeletal Research
Institute of Inflammation and Repair
The University of Manchester
Manchester Academic Health Science Centre
Room 2.809 Stopford Building
Oxford Road
M13 9PT

PA - Gillian Amroon - Telephone - 0161 275 5044 - E-mail - Gillian.Amroon@manchester.ac.uk


I am a Reader in Rheumatic Disease Epidemiology in the Arthritis Research UK Centre for Epidemiology, part of the Centre for Musculoskeletal Research. My  main research interests are in the short and longterm outcomes in adult and childhood inflammatory arthritis, including a greater understanding of the role treatments play in these outcomes.

I am also an Honorary Rheumatology Consultant at the Kellgren Centre for Rheumatology, part of the  Central Manchester Foundation Trust.

Additional roles include Deputy Director for the MRes Medical Sciences (for intercalatintg medical students) and Epidemiology Module Lead for the MSc in Clinical Rheumatology.

Memberships of Committees and Professional Bodies

Methodological Knowledge

Epidemiology and biostatistics including analysis of longterm observational cohort studies.


  • Supervision of higher level degress (MRes, MSc and PhD)
  • Manchester Medical School - Academic Advisor
  • MRes in Medical Sciences - Deputy Programme Director
  • Epidemiology Module Lead - MSc in Clinical Rheumatology


I completed my Bachelors of Science and medical degree at the University of Manitoba in Canada. This was followed by training in internal medicine in Winnipeg, Canada and a fellowship in rheumatology at the University of Toronto. I subsequently worked as an Arthritis Society of Canada/CIHR Research Fellow at the Arthritis Research UK (formerly arc) Epidemiology Unit in Manchester, being awarded my PhD in 2005. I am currently a Reader in Rheumatic Disease Epidemiology at the University of Manchester and an Honorary Rheumatology Consultant at the Manchester Royal Infirmary, Manchester, UK.

My main research interests centre on outcomes in inflammatory arthritis, with a particular focus on pharmacoepidemiology. I am a principal investigator for the British Society for Rheumatology Biologics Register (BSRBR), which is prospectively collecting information on all patients receiving biologic therapy for a rheumatic disease throughout the United Kingdom. Work from this project has assessed the real-world efficacy of anti-TNF agents for rheumatoid arthritis as well as predictors of response and the risk of adverse events, including infection and myocardial infarction. My research in paediatrics includes the Childhood Arthritis Prospective Study (CAPS), an inception cohort which is studying both short and long-term outcomes in children diagnosed in the UK with juvenile idiopathic arthritis and 2 biologic registers in children: the Arthritis Research UK funded Safety and Efficacy of Biologics in Children (Extended Biologics Study) and the BSPAR Etanercept Register, which is focusing on the short and long-term safety of the use of biologic drugs in children with arthritis.

I supervise a number of PhD and Masters students working on these and other projects.


  • Bachelor of Science (1992) - University of Manitoba, Canada
  • MD (1996) - University of Manitoba, Canada
  • Fellow of the Royal College of Physicians of Canada (General Medicine and Rheumatology) - 2000
  • PhD (2005) - University of Manchester, UK

Collaborators and affiliated staff

  • Deborah Symmons (Manchester)
  • Anne Barton (Manchester)
  • Wendy Thomson (Manchester)
  • Michael Beresford (Liverpool)
  • Eileen Baildam (Liverpool)
  • Lucy Wedderburn (London)
  • Joyce Davidson (Glasgow)
  • Helen Foster (Newcastle)
  • Kath Watson (Manchester)
  • Chris Deighton (Derby)
  • Anja Strangfeld (Berlin)
  • Angela Zink (Berlin)
  • Johan Askling (Stockholm)
  • Loreto Carmona (Madrid)

Selected publications


  • Bluett, J., Morgan, C., Barton, A., BRAGGSS, B., Thurston, L., Plant, D., Hyrich, K., Morgan, A., Wilson, A., Isaacs, J. & Cordingley, L (2015). Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Rheumatology (Oxford), 54(3), 494-499. eScholarID:234413 | PMID:25213131 | DOI:10.1093/rheumatology/keu358
  • Kearsley-Fleet, L., Hyrich, K., Davies, R., Lunt, M. & Southwood, T (2015). Growth in children and adolescents with juvenile idiopathic arthritis over 2 years of treatment with etanercept: results from the British Society for Paediatric and Adolescent Rheumatology Etanercept Cohort Study. Rheumatology (Oxford), [E-pub ahead of print], eScholarID:258962 | PMID:25638806 | DOI:10.1093/rheumatology/keu489
  • Suzanne MM Verstappen, Joanna Cobb, Helen E Foster, Bo Fu, Eileen Baildam, Lucy R Wedderburn, Joyce E Davidson, John Ioannou, Alice Chieng, Kimme L Hyrich and Wendy Thomson. (2015). Low socio-economic status is associated with high physical limitations and low illness self-perception in patients with juvenile idiopathic arthritis: Results from the Childhood Arthritis Prospective Study (CAPS). Arthritis Care Res (Hoboken), 67(3), 382-389. eScholarID:232944 | PMID:25187470 | DOI:10.1002/acr.22466


  • Bluett, et al (2014). Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Pharmacogenomics J, 14(2), 171-175. eScholarID:201863 | PMID:23856853 | DOI:10.1038/tpj.2013.26
  • Kearsley-Fleet, L., Závada, J., Hetland, M., Nordström, D., Aaltonen, K., Listing, J., Zink, A., Gati, T., Rojkovich, B., Iannone, F., Gremese, E., van Riel, P., van de Laar, M., Lie, E., Kvien, T., Canhão, H., Fonseca, J., Rotar, Z., Loza, E., Carmona, L., Askling, J., Johansson, K., Finckh, A., Dixon, W. & Hyrich, K (2014). The EULAR Study Group for Registers and Observational Drug Studies: comparability of the patient case mix in the European biologic disease modifying anti-rheumatic drug registers. Rheumatology (Oxford), [Epub ahead of print], eScholarID:242324 | PMID:25433042 | DOI:10.1093/rheumatology/keu446
  • Mathews, R., Robinson, J., Battellino, M., Wong, C., Taylor, J., , B., Eyre, S., Churchman, S., Wilson, A., Isaacs, J., Hyrich, K., Barton, A., Plant, D., Savic, S., Cook, G., Sarzi-Puttini, P., Emery, P., Barrett, J., Morgan, A. & McDermott, M (2014). Evidence of NLRP3-inflammasome activation in rheumatoid arthritis (RA); genetic variants within the NLRP3-inflammasome complex in relation to susceptibility to RA and response to anti-TNF treatment. Ann Rheum Dis, 73(6), 1202-1210. eScholarID:197153 | PMID:23687262 | DOI:10.1136/annrheumdis-2013-203276
  • Mercer, L., Lunt, M., Low, A., Dixon, W., Watson, K., Symmons, D. & Hyrich, K (2014). Risk of solid cancer in patients exposed to anti-tumour necrosis factor therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis. Ann Rheum Dis, [Epub ahead of print], eScholarID:223617 | PMID:24685910 | DOI:10.1136/annrheumdis-2013-204851
  • Silva-Fernandez, L. & Hyrich, K (2014). Rheumatoid arthritis: When TNF inhibitors fail in RA-weighing up the options. Nat Rev Rheumatol, 10(5), 262-264. eScholarID:221933 | PMID:24614594 | DOI:10.1038/nrrheum.2014.34
  • Závada, J., Lunt, M., Davies, R., Low, A., Mercer, L., Galloway, J., Watson, K., Symmons, D., Hyrich, K. & , B (2014). The risk of gastrointestinal perforations in patients with rheumatoid arthritis treated with anti-TNF therapy: results from the BSRBR-RA. Ann Rheum Dis, 73(1), 252-255. eScholarID:197157 | PMID:23644671 | DOI:10.1136/annrheumdis-2012-203102
  • Yarwood,A.; Viatte S., Plant D., Morgan A.W., Isaacs J., Wilson A.G., Hyrich K., Eyre S., Barton A., Biologics_in_Rheumatoid_Arthritis_Genetics_and_Genomics. (2014). Testing the role of vitamin D in response to antitumour necrosis factor alpha therapy in a UK cohort: a Mendelian randomisation approach. Annals of the Rheumatic Diseases, 73(5), 938-940. eScholarID:234475 | DOI:10.1136/annrheumdis-2013-204443


  • Coates, L., Tillett, W., Chandler, D., Helliwell, P., Korendowych, E., Kyle, S., McInnes, I., Oliver, S., Ormerod, A., Smith, C., Symmons, D., Waldron, N. & McHugh, N (2013). The 2012 BSR and BHPR guideline for the treatment of psoriatic arthritis with biologics. Rheumatology (Oxford), 52(10), 1754-1757. eScholarID:206101 | PMID:23887065 | DOI:10.1093/rheumatology/ket187
  • Humphreys, J., Verstappen, S., Hyrich, K., Chipping, J. & Symmons, D (2013). 2010 ACR/EULAR classification criteria for rheumatoid arthritis predict increased mortality in patients with early arthritis: results from the Norfolk Arthritis Register. Rheumatology (Oxford), 52(6), 1141-1142. eScholarID:191607 | PMID:23463807 | DOI:10.1093/rheumatology/ket113
  • Hyrich, K. & Verstappen, S (2013). Biologic therapies and pregnancy: the story so far. Rheumatology (Oxford), [Epub ahead of print], eScholarID:216516 | PMID:24352337 | DOI:10.1093/rheumatology/ket409
  • McErlane, F., Beresford, M., Baildam, E., Chieng, S., Davidson, J., Foster, H., Gardner-Medwin, J., Lunt, M., Wedderburn, L., Thomson, W., Hyrich, K. & Childhood_Arthritis_Prospective_Study_(CAPS), C (2013). Validity of a three-variable Juvenile Arthritis Disease Activity Score in children with new-onset juvenile idiopathic arthritis. Ann Rheum Dis, 72(12), 1983-1988. eScholarID:186037 | PMID:23256951 | DOI:10.1136/annrheumdis-2012-202031
  • McErlane, F., Beresford, M., Baildam, E., Thomson, W. & Hyrich, K (2013). Recent developments in disease activity indices and outcome measures for juvenile idiopathic arthritis. Rheumatology (Oxford), 52(11), 1941-1951. eScholarID:193908 | PMID:23630368 | DOI:10.1093/rheumatology/ket150
  • McErlane, F., Foster, H., Davies, R., Lunt, M., Watson, K., Symmons, D. & Hyrich, K (2013). Biologic treatment response among adults with juvenile idiopathic arthritis: results from the British Society for Rheumatology Biologics Register. Rheumatology (Oxford), [Epub ahead of print], eScholarID:206102 | PMID:23873820 | DOI:10.1093/rheumatology/ket248


  • Bowes, J, Potter, C, Gibbons, LJ, Hyrich, KL, Plant, D, BRAGGSS, Morgan, A, Wilson, A, Isaacs, J, Worthington, J, Barton, A. (2009). Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. Pharmacogenet Genomics, 19(4), 319-323. eScholarID:1d19079 | DOI:10.1097/FPC.0b013e328328d51f
  • Harrison MJ, Dixon WG, Watson KD, King YE, Groves R, Hyrich KL, Symmons D, BSRBR Control Centre Consortium. (2009). Rates of new-onset psoriasis in patients with rheumatoid arthritis receiving anti-TNF{alpha} therapy. Results from the British Society for Rheumatology Biologics Register. Ann Rheum Dis, 68(2), 209-215. eScholarID:1d17129 | DOI:10.1136/ard.2007.087288

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