Professor Jane Worthington PhD

Photograph of Jane Worthington

Professor of Chronic Disease Genetics

Arthritis Research UK Centre for Genetics and Genomics

Centre for Musculoskeletal Research
Institute of Inflammation and Repair
The University of Manchester
Manchester Academic Health Science Centre
Room 2.809 Stopford Building
University of Manchester
Oxford Road
Manchester
M13 9PT
 

 

Role

Professor of Chronic Disease Genetics.

Lead, Centre for Musculoskeletal Research, Institute of Inflammation and Repair.

Director, Arthritis Research UK Centre for Genetics and Genomics.

Research Theme Lead for Prevention of disease and the complications of treatment at the NIHR Manchester Musculoskeletal Biomedical Research Unit

Honorary Research Principal Investigator, Central Manchester & Manchester Children's University Hospital, NHS Trust.

Research

Genetics and genomics: studies on the genetic contribution to a range of rheumatological disorders but with a specific focus on inflammatory joint disease. More

I am Research Theme Lead for the Prevention of disease and the complications of treatment research at the NIHR Manchester Musculoskeletal Biomedical Research Unit .




 

Publications

2014

  • Banka, S., Cain, S., Carim, S., Daly, S., Urquhart, J., Erdem, G., Harris, J., Bottomley, M., Donnai, D., Kerr, B., Kingston, H., Superti-Furga, A., Unger, S., Ennis, H., Worthington, J., Herrick, A., Merry, C., Yue, W., Kielty, C. & Newman, W (2014). Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis. Ann Rheum Dis, [Epub ahead of print], eScholarID:218656 | PMID:24442880 | DOI:10.1136/annrheumdis-2013-204309
  • Kim, K., Bang, S., Lee, H., Cho, S., Choi, C., Sung, Y., Kim, T., Jun, J., Yoo, D., Kang, Y., Kim, S., Suh, C., Shim, S., Lee, S., Lee, J., Chung, W., Choe, J., Shin, H., Lee, J., Han, B., Nath, S., Eyre, S., Bowes, J., Pappas, D., Kremer, J., Gonzalez-Gay, M., Rodriguez-Rodriguez, L., Arlestig, L., Okada, Y., Diogo, D., Liao, K., Karlson, E., Raychaudhuri, S., Rantapää-Dahlqvist, S., Martin, J., Klareskog, L., Padyukov, L., Gregersen, P., Worthington, J., Greenberg, J., Plenge, R. & Bae, S (2014). High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. Ann Rheum Dis, [Epub ahead of print], eScholarID:220814 | PMID:24532676 | DOI:10.1136/annrheumdis-2013-204749
  • López-Isac, E., Bossini-Castillo, L., Simeon, C., Egurbide, M., Alegre-Sancho, J., Callejas, J., Roman-Ivorra, J., Freire, M., Beretta, L., Santaniello, A., Airó, P., Lunardi, C., Hunzelmann, N., Riemekasten, G., Witte, T., Kreuter, A., Distler, J., Schuerwegh, A., Vonk, M., Voskuyl, A., Shiels, P., van Laar, J., Fonseca, C., Denton, C., Herrick, A., Worthington, J., Assassi, S., Koeleman, B., Mayes, M., Radstake, T. & Martin, J (2014). A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility. Arthritis Res Ther, 16(1), R6. eScholarID:220815 | PMID:24401602 | DOI:10.1186/ar4432
  • Mayes, et al (2014). Immunochip analysis identifies multiple susceptibility Loci for systemic sclerosis. Am J Hum Genet, 94(1), 47-61. eScholarID:218663 | PMID:24387989 | DOI:10.1016/j.ajhg.2013.12.002
  • Okada, et al (2014). Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature, 506(7488), 376-381. eScholarID:216734 | PMID:24390342 | DOI:10.1038/nature12873
  • Okada, et al (2014). Integration of Sequence Data from a Consanguineous Family with Genetic Data from an Outbred Population Identifies PLB1 as a Candidate Rheumatoid Arthritis Risk Gene. PLoS One, 9(2), e87645. eScholarID:220816 | PMID:24520335 | DOI:10.1371/journal.pone.0087645
  • Orozco, G., Viatte, S., Bowes, J., Martin, P., Wilson, A., Morgan, A., Steer, S., Wordsworth, P., Hocking, L., UKRAG_consortium, U., WTCCC_consortium, W., BRAGGSS_consortium, B., Barton, A., Worthington, J. & Eyre, S (2014). Novel RA susceptibility locus at 22q12 identified in an extended UK genome wide association study. Arthritis Rheum, 66(1), 24-30. eScholarID:211583 | PMID:24114500 | DOI:10.1002/art.38196

2013

  • Ali, F., Barton, A., Smith, R., Bowes, J., Flynn, E., Mangino, M., Bataille, V., Foerster, J., Worthington, J., Griffiths, C. & Warren, R (2013). An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene. Br J Dermatol, 168(4), 864-866. eScholarID:181474 | PMID:23106574 | DOI:10.1111/bjd.12106
  • Bossini-Castillo, et al (2013). Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study. Ann Rheum Dis, 72(4), 602-607. eScholarID:168312 | PMID:22896740 | DOI:10.1136/annrheumdis-2012-201888
  • Carmona, F., Cénit, M., Diaz-Gallo, L., Broen, J., Simeón, C., Carreira, P., Callejas-Rubio, J., Fonollosa, V., López-Longo, F., González-Gay, M., Hunzelmann, N., Riemekasten, G., Witte, T., Kreuter, A., Distler, J., Madhok, R., Shiels, P., van Laar, J., Schuerwegh, A., Vonk, M., Voskuyl, A., Fonseca, C., Denton, C., Herrick, A., Worthington, J., Arnett, F., Tan, F., Assassi, S., Radstake, T., Mayes, M. & Martín, J (2013). New insight on the Xq28 association with systemic sclerosis. Ann Rheum Dis, 72(12), 2032-2038. eScholarID:190134 | PMID:23444193 | DOI:10.1136/annrheumdis-2012-202742
  • Carmona, F., Martin, J., Beretta, L., Simeón, C., Carreira, P., Callejas, J., Fernández-Castro, M., Sáez-Comet, L., Beltrán, E., Camps, M., Egurbide, M., Spanish_Scleroderma_Group, S., Airó, P., Scorza, R., Lunardi, C., Hunzelmann, N., Riemekasten, G., Witte, T., Kreuter, A., Distler, J., Madhok, R., Shiels, P., van Laar, J., Fonseca, C., Denton, C., Herrick, A., Worthington, J., Schuerwegh, A., Vonk, M., Voskuyl, A., Radstake, T. & Martín, J (2013). The Systemic Lupus Erythematosus IRF5 Risk Haplotype Is Associated with Systemic Sclerosis. PLoS One, 8(1), e54419. eScholarID:187661 | PMID:23372721 | DOI:10.1371/journal.pone.0054419
  • Cobb, J., Plant, D., Flynn, E., Tadjeddine, M., Dieudé, P., Cornélis, F., Arlestig, L., Dahlqvist, S., Goulielmos, G., Boumpas, D., Sidiropoulos, P., Krintel, S., Ornbjerg, L., Hetland, M., Klareskog, L., Haeupl, T., Filer, A., Buckley, C., Raza, K., Witte, T., Schmidt, R., Fitzgerald, O., Veale, D., Eyre, S. & Worthington, J (2013). Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans. PLoS One, 8(6), e66456. eScholarID:201565 | PMID:23840476 | DOI:10.1371/journal.pone.0066456
  • Diaz-Gallo, et al (2013). Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility. Ann Rheum Dis, 72(7), 1233-1238. eScholarID:183353 | PMID:23172754 | DOI:10.1136/annrheumdis-2012-202357
  • Diogo, D., Kurreeman, F., Stahl, E., Liao, K., Gupta, N., Greenberg, J., Rivas, M., Hickey, B., Flannick, J., Thomson, B., Guiducci, C., Ripke, S., Adzhubey, I., Barton, A., Kremer, J., Alfredsson, L., Sunyaev, S., Martin, J., Zhernakova, A., Bowes, J., Eyre, S., Siminovitch, K., Gregersen, P., Worthington, J., Klareskog, L., Padyukov, L., Raychaudhuri, S. & Plenge, R (2013). Rare, Low-Frequency, and Common Variants in the Protein-Coding Sequence of Biological Candidate Genes from GWASs Contribute to Risk of Rheumatoid Arthritis. Am J Hum Genet, 92(1), 15-27. eScholarID:186071 | PMID:23261300 | DOI:10.1016/j.ajhg.2012.11.012
  • Gusev, A., Bhatia, G., Zaitlen, N., Vilhjalmsson, B., Diogo, D., Stahl, E., Gregersen, P., Worthington, J., Klareskog, L., Raychaudhuri, S., Plenge, R., Pasaniuc, B. & Price, A (2013). Quantifying Missing Heritability at Known GWAS Loci. PLoS Genet, 9(12), e1003993. eScholarID:218657 | PMID:24385918 | DOI:10.1371/journal.pgen.1003993
  • Li, G., Diogo, D., Wu, D., Spoonamore, J., Dancik, V., Franke, L., Kurreeman, F., Rossin, E., Duclos, G., Hartland, C., Zhou, X., Li, K., Liu, J., De Jager, P., Siminovitch, K., Zhernakova, A., Raychaudhuri, S., Bowes, J., Eyre, S., Padyukov, L., Gregersen, P., Worthington, J., Rheumatoid_Arthritis_Consortium_International_(RACI), R., Gupta, N., Clemons, P., Stahl, E., Tolliday, N. & Plenge, R (2013). Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway. PLoS Genet, 9(5), e1003487. eScholarID:198292 | PMID:23696745 | DOI:10.1371/journal.pgen.1003487
  • Martin, et al (2013). A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. Hum Mol Genet, 22(19), 4021-4029. eScholarID:198294 | PMID:23740937 | DOI:10.1093/hmg/ddt248
  • McAllister, K., Yarwood, A., Morgan, A., UKRAG_Consortium, U., RACI, R., Kremer, J., Pappas, D., Gregersen, P., Klareskog, L., Plenge, R., Barton, A., Greenberg, J., Bowes, J., Worthington, J., Eyre, S., Orozco, G., Viatte, S., Diogo, D., Hocking, L., Steer, S., Wordsworth, P. & Wilson, A (2013). Brief Report: Identification of BACH2 and RAD51B as Rheumatoid Arthritis Susceptibility Loci in a Meta-Analysis of Genome-Wide Data. Arthritis Rheum, 65(12), 3058-3062. eScholarID:207513 | PMID:24022229 | DOI:10.1002/art.38183
  • Scott, I., Seegobin, S., Steer, S., Tan, R., Forabosco, P., Hinks, A., Eyre, S., Morgan, A., Wilson, A., Hocking, L., Wordsworth, P., Barton, A., Worthington, J., Cope, A. & Lewis, C (2013). Predicting the Risk of Rheumatoid Arthritis and Its Age of Onset through Modelling Genetic Risk Variants with Smoking. PLoS Genet, 9(9), e1003808. eScholarID:209928 | PMID:24068971 | DOI:10.1371/journal.pgen.1003808
  • Taylor, L., Twigg, S., Worthington, J., Emery, P., Morgan, A., Wilson, A. & Teare, M (2013). Metaanalysis of the Association of Smoking and PTPN22 R620W Genotype on Autoantibody Status and Radiological Erosions in Rheumatoid Arthritis. J Rheumatol, 40(7), 1048-4053. eScholarID:198293 | PMID:23637320 | DOI:10.3899/jrheum.120784
  • Viatte, S., Plant, D., Lunt, M., Fu, B., Flynn, E., Parker, B., Galloway, J., Solymossy, C., Worthington, J., Symmons, D., Dixey, J., Young, A. & Barton, A (2013). Investigation of Rheumatoid Arthritis Genetic Susceptibility Markers in the Early Rheumatoid Arthritis Study Further Replicates the TRAF1 Association with Radiological Damage. J Rheumatol, 40(2), 144-156. eScholarID:186023 | PMID:23242182 | DOI:10.3899/jrheum.121034
  • Yarwood, A., Han, B., Raychaudhuri, S., Bowes, J., Lunt, M., Pappas, D., Kremer, J., Greenberg, J., Plenge, R., Rheumatoid_Arthritis_Consortium_International_(RACI), R., Worthington, J., Barton, A. & Eyre, S (2013). A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk. Ann Rheum Dis, n/a, n/a. eScholarID:211584 | PMID:24092415 | DOI:10.1136/annrheumdis-2013-204133
  • Yarwood, A., Martin, P., Bowes, J., Lunt, M., Worthington, J., Barton, A. & Eyre, S (2013). Enrichment of vitamin D response elements in RA-associated loci supports a role for vitamin D in the pathogenesis of RA. Genes Immun, [Epub ahead of print], eScholarID:197154 | PMID:23636220 | DOI:10.1038/gene.2013.23

2012

  • Bossini-Castillo, et al (2012). A GWAS follow-up study reveals the association of IL12RB2 gene with Systemic Sclerosis in Caucasian populations. Hum Mol Genet, 21(4), 926-933. eScholarID:137408 | PMID:22076442 | DOI:10.1093/hmg/ddr522
  • Bossini-Castillo, L., Simeon, C., Beretta, L., Broen, J., Vonk, M., Callejas, J., Carreira, P., Rodriguez-Rodriguez, L., Garcia-Portales, R., Gonzalez-Gay, M., Castellvi, I., Camps, M., Tolosa, C., Vicente-Rabaneda, E., Egurbide, M., Ssg, S., Schuerwegh, A., Hesselstrand, R., Lunardi, C., van Laar, J., Shiels, P., Herrick, A., Worthington, J., Denton, C., Radstake, T., Fonseca, C. & Martin, J (2012). KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor. Arthritis Res Ther, 14(6), R273. eScholarID:186050 | PMID:23270786 | DOI:10.1186/ar4124
  • Broen, J., Bossini-Castillo, L., Van Bon, L., Vonk, M., Knaapen, H., Beretta, L., Rueda, B., Hesselstrand, R., Herrick, A., Worthington, J., Hunzelman, N., Denton, C., Fonseca, C., Riemekasten, G., Kiener, H., Scorza, R., Simeon, C., Ortego-Centeno, N., Spanish_Scleroderma_Group, S., Gonzalez-Gay, M., Airo, P., Coenen, M., Martin, J. & Radstake, T (2012). A rare polymorphism in Toll Like Receptor 2 is associated with systemic sclerosis phenotype and increases production of inflammatory mediators. Arthritis Rheum, 64(1), 264-271. eScholarID:131397 | PMID:21905008 | DOI:10.1002/art.33325
  • Broen, J., Dieude, P., Vonk, M., Beretta, L., Carmona, F., Herrick, A., Worthington, J., Hunzelmann, N., Riemekasten, G., Kiener, H., Scorza, R., Simeon, C., Fonollosa, V., Carreira, P., Ortego-Centeno, N., Gonzalez-Gay, M., Airo, P., Coenen, M., Tsang, K., Aliprantis, A., Martin, J., Allanore, Y. & Radstake, T (2012). Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression. J Rheumatol, 39(1), 112-118. eScholarID:137406 | PMID:22045834 | DOI:10.3899/jrheum.110235
  • Cénit, et al (2012). Influence of the IL6 Gene in Susceptibility to Systemic Sclerosis. J Rheumatol, 39(12), 2294-2302. eScholarID:176098 | PMID:23027890 | DOI:10.3899/jrheum.120506
  • Eyre, et al (2012). High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet, 44(12), 1336-1340. eScholarID:181473 | PMID:23143596 | DOI:10.1038/ng.2462
  • Gerlag, D., Raza, K., van Baarsen, L., Brouwer, E., Buckley, C., Burmester, G., Gabay, C., Catrina, A., Cope, A., Cornelis, F., Dahlqvist, S., Emery, P., Eyre, S., Finckh, A., Gay, S., Hazes, J., van der Helm-van Mil, A., Huizinga, T., Klareskog, L., Kvien, T., Lewis, C., Machold, K., Rönnelid, J., Schaardenburg, D., Schett, G., Smolen, J., Thomas, S., Worthington, J. & Tak, P (2012). EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis. Ann Rheum Dis, 71(5), 638-641. eScholarID:157097 | PMID:22387728 | DOI:10.1136/annrheumdis-2011-200990
  • Hinks, A., Cobb, J., Sudman, M., Eyre, S., Martin, P., Flynn, E., Packham, J., (CAPS), C., UK_RA_Genetics_(UKRAG)_Consortium, U., British_Society_of_Paediatric_and_Adolescent_Rheumatology_(BSPAR)_Study_Group, B., Barton, A., Worthington, J., Langefeld, C., Glass, D., Thompson, S. & Thomson, W (2012). Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap. Ann Rheum Dis, 71(7), 1117-1121. eScholarID:155339 | PMID:22294642 | DOI:10.1136/annrheumdis-2011-200814
  • Kurreeman, F., Stahl, E., Okada, Y., Liao, K., Diogo, D., Raychaudhuri, S., Freudenberg, J., Kochi, Y., Patsopoulos, N., Gupta, N., CLEAR_Investigators, C., Sandor, C., Bang, S., Lee, H., Padyukov, L., Suzuki, A., Siminovitch, K., Worthington, J., Gregersen, P., Hughes, L., Reynolds, R., Bridges, S., Bae, S., Yamamoto, K. & Plenge, R (2012). Use of a Multiethnic Approach to Identify Rheumatoid- Arthritis-Susceptibility Loci, 1p36 and 17q12. Am J Hum Genet, 90(3), 524-532. eScholarID:157096 | PMID:22365150 | DOI:10.1016/j.ajhg.2012.01.010
  • Mackie, S., Taylor, J., Martin, S., YEAR_Consortium, Y., UKRAG_Consortium, U., Wordsworth, P., Steer, S., Wilson, A., Worthington, J., Emery, P., Barrett, J. & Morgan, A (2012). A spectrum of susceptibility to rheumatoid arthritis within HLA-DRB1: stratification by autoantibody status in a large UK population. Genes Immun, 13(2), 120-128. eScholarID:130276 | PMID:21881596 | DOI:10.1038/gene.2011.60
  • Mackie, S., Taylor, J., Twigg, S., Martin, S., Steer, S., Worthington, J., Barton, A., Wilson, A., Hocking, L., Young, A., Emery, P., Barrett, J. & Morgan, A (2012). Relationship between area-level socio-economic deprivation and autoantibody status in patients with rheumatoid arthritis: multicentre cross-sectional study. Ann Rheum Dis, 71(10), 1640-1645. eScholarID:157950 | PMID:22440825 | DOI:10.1136/annrheumdis-2011-201003
  • Martin, et al (2012). Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up. Hum Mol Genet, 21(12), 2825-2835. eScholarID:157951 | PMID:22407130 | DOI:10.1093/hmg/dds099
  • Martin, et al (2012). The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis. Genes Immun, 13(2), 191-196. eScholarID:134291 | PMID:22012429 | DOI:10.1038/gene.2011.72
  • Maxwell, J., Marinou, I., Kuet, K., Orozco, G., Moore, D., Barton, A., Worthington, J. & Wilson, G (2012). Rheumatoid Arthritis-associated Polymorphisms at 6q23 Are Associated with Radiological Damage in Autoantibody-positive RA. J Rheumatol, 39(9), 1781-1785. eScholarID:165423 | PMID:22798268 | DOI:10.3899/jrheum.120144
  • Okada, et al (2012). Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet, 44(5), 511-516. eScholarID:159014 | PMID:22446963 | DOI:10.1038/ng.2231
  • Plant, D., Farragher, T., Flynn, E., Martin, P., Eyre, S., Bunn, D., Worthington, J., Symmons, D., Barton, A. & Thomson, W (2012). A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register. Pharmacogenomics J, 12(2), 128-133. eScholarID:92334 | PMID:20921970 | DOI:10.1038/tpj.2010.80
  • Raychaudhuri, S., Sandor, C., Stahl, E., Freudenberg, J., Lee, H., Jia, X., Alfredsson, L., Padyukov, L., Klareskog, L., Worthington, J., Siminovitch, K., Bae, S., Plenge, R., Gregersen, P. & de Bakker, P (2012). Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet, 44(3), 291-296. eScholarID:155338 | PMID:22286218 | DOI:10.1038/ng.1076
  • Ronninger, M., Seddighzadeh, M., Eike, M., Plant, D., Daha, N., Skinningsrud, B., Worthington, J., Kvien, T., Toes, R., Lie, B., Alfredsson, L. & Padyukov, L (2012). Interaction Analysis between HLA-DRB1 Shared Epitope Alleles and MHC Class II Transactivator CIITA Gene with Regard to Risk of Rheumatoid Arthritis. PLoS One, 7(3), e32861. eScholarID:159013 | PMID:22461888 | DOI:10.1371/journal.pone.0032861
  • Stahl, E., Wegmann, D., Trynka, G., Gutierrez-Achury, J., Do, R., Voight, B., Kraft, P., Chen, R., Kallberg, H., Kurreeman, F., Diabetes_Genetics_Replication_and_Meta-analysis_Consortium, D., Myocardial_Infarction_Genetics_Consortium, M., Kathiresan, S., Wijmenga, C., Gregersen, P., Alfredsson, L., Siminovitch, K., Worthington, J., de Bakker, P., Raychaudhuri, S. & Plenge, R (2012). Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nat Genet, 44(5), 482-489. eScholarID:159012 | PMID:22446960 | DOI:10.1038/ng.2232
  • Tsoi, et al (2012). Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet, eScholarID:181472 | PMID:23143594 | DOI:10.1038/ng.2467
  • Viatte, S., Plant, D., Bowes, J., Lunt, M., Eyre, S., Barton, A. & Worthington, J (2012). Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients. Ann Rheum Dis, 71(12), 1984-1990. eScholarID:162788 | PMID:22661644 | DOI:10.1136/annrheumdis-2011-201225
  • Wellcome_Trust_Case_Control_Consortium, et al (2012). Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet, 44(12), 1294-1301. eScholarID:181470 | PMID:23104008 | DOI:10.1038/ng.2435
  • Zaitlen, et al (2012). Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies. PLoS Genet, 8(11), e1003032. eScholarID:181471 | PMID:23144628 | DOI:10.1371/journal.pgen.1003032

2011

  • Bossini-Castillo, et al (2011). A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort. Ann Rheum Dis, 70(4), 638-641. eScholarID:103644 | PMID:21187296 | DOI:10.1136/ard.2010.141838
  • Bossini-Castillo, et al (2011). Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population. Rheumatology (Oxford), 50(11), 1976-1981. eScholarID:134290 | PMID:21875883 | DOI:10.1093/rheumatology/ker259
  • Bowes, J., Eyre, S., Flynn, E., Ho, P., Salah, S., Warren, R., Marzo-Ortega, H., Coates, L., McManus, R., Ryan, A., Kane, D., Korendowych, E., McHugh, N., Fitzgerald, O., Packham, J., Morgan, A., Griffiths, C., Bruce, I., Worthington, J. & Barton, A (2011). Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris. Ann Rheum Dis, 70(6), 1016-1019. eScholarID:120028 | PMID:21349879 | DOI:10.1136/ard.2010.143123
  • Carmona, et al (2011). Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis. Ann Rheum Dis, 70(11), 2050-2052. eScholarID:123234 | PMID:21571730 | DOI:10.1136/ard.2010.148874
  • Chen, R., Stahl, E., Kurreeman, F., Gregersen, P., Siminovitch, K., Worthington, J., Padyukov, L., Raychaudhuri, S. & Plenge, R (2011). Fine mapping the TAGAP risk locus in rheumatoid arthritis. Genes Immun, 12(4), 314-318. eScholarID:120029 | PMID:21390051 | DOI:10.1038/gene.2011.8
  • Cotsapas, C., Voight, B., Rossin, E., Lage, K., Neale, B., Wallace, C., Abecasis, G., Barrett, J., Behrens, T., Cho, J., De Jager, P., Elder, J., Graham, R., Gregersen, P., Klareskog, L., Siminovitch, K., van Heel, D., Wijmenga, C., Worthington, J., Todd, J., Hafler, D., Rich, S. & Daly, M (2011). Pervasive sharing of genetic effects in autoimmune disease. PLoS Genetics, 7(8), e1002254. eScholarID:130277 | PMID:21852963 | DOI:10.1371/journal.pgen.1002254
  • Diaz-Gallo, et al (2011). Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis. Ann Rheum Dis, 70(3), 454-462. eScholarID:98940 | PMID:21131644 | DOI:10.1136/ard.2010.130138
  • Gorlova, et al (2011). Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. PLoS Genet, 7(7), e1002178. eScholarID:131396 | PMID:21779181 | DOI:10.1371/journal.pgen.1002178
  • Hinks, A., Martin, P., Flynn, E., Eyre, S., Packham, J., Barton, A., (CAPS), C.A., Group, B.S., Worthington, J. & Thomson, W (2011). Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis. Arthritis Res Ther, 13(1), R12. eScholarID:118340 | PMID:21281511 | DOI:10.1186/ar3235
  • Ke, X., Eyre, S., Lawrence, R., Bowes, J., Panoutsopoulou, K., Barton, A., Thomson, W., Worthington, J. & Zeggini, E (2011). Examining the overlap between genome-wide rare variant association signals and linkage peaks in rheumatoid arthritis. Arthritis Rheum, 63(6), 1522-1526. eScholarID:120030 | PMID:21370227 | DOI:10.1002/art.30315
  • Orozco, G., Barton, A., Eyre, S., Ding, B., Worthington, J., Ke, X. & Thomson, W (2011). HLA-DPB1-COL11A2 and three additional xMHC loci are independently associated with RA in a UK cohort. Genes Immun, 12(3), 169-175. eScholarID:118626 | PMID:21293383 | DOI:10.1038/gene.2010.57
  • Orozco, G., Eyre, S., Hinks, A., Bowes, J., Morgan, A., Wilson, A., Wordsworth, P., Steer, S., Hocking, L., UKRAG_consortium, U., Thomson, W., Worthington, J. & Barton, A (2011). Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis, 70(3), 463-468. eScholarID:94846 | PMID:21068098 | DOI:10.1136/ard.2010.137174
  • Plant, D., Thomson, W., Lunt, M., Flynn, E., Martin, P., Eyre, S., Farragher, T., Bunn, D., Worthington, J., Symmons, D. & Barton, A (2011). The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register. Rheumatology (Oxford), 50(1), 58-84. eScholarID:77863 | PMID:20219786 | DOI:10.1093/rheumatology/keq032
  • Warren, R., Smith, R., Flynn, E., Bowes, J., UKRAG_Consortium, U., Eyre, S., Worthington, J., Barton, A. & Griffiths, C (2011). A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21. Br J Dermatol, 164(3), 660-4. eScholarID:120027 | PMID:21375519 | DOI:10.1111/j.1365-2133.2011.10237.x
  • Zhernakova, A., Stahl, E., Trynka, G., Raychaudhuri, S., Festen, E., Franke, L., Westra, H., Fehrmann, R., Kurreeman, F., Thomson, B., Gupta, N., Romanos, J., McManus, R., Ryan, A., Turner, G., Brouwer, E., Posthumus, M., Remmers, E., Tucci, F., Toes, R., Grandone, E., Mazzilli, M., Rybak, A., Cukrowska, B., Coenen, M., Radstake, T., van Riel, P., Li, Y., de Bakker, P., Gregersen, P., Worthington, J., Siminovitch, K., Klareskog, L., Huizinga, T., Wijmenga, C. & Plenge, R (2011). Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet, 7(2), e1002004. eScholarID:120031 | PMID:21383967 | DOI:10.1371/journal.pgen.1002004

2010

  • Alizadeh, B., Broen, J., Rueda, B., Hesselstrand, R., Wuttge, D., Simeon, C., Ortego-Centeno, N., Gonzalez-Gay, M., Pros, A., Herrick, A., Worthington, J., Denton, C., Fonseca, C., Riemekasten, G., Vonk, M., van den Hoogen, F., Guiducci, S., Matucci-Cerinic, M., Scorza, R., Beretta, L., Airó, P., Coenen, M., Martin, J., Koeleman, B. & Radstake, T (2010). Functional Variants of Fc Gamma Receptor (FCGR2A) and FCGR3A Are Not Associated with Susceptibility to Systemic Sclerosis in a Large European Study (EUSTAR). J Rheumatol, 37(8), 1673-1679. eScholarID:85018 | PMID:20551103 | DOI:10.3899/jrheum.091259
  • Bowes, J., Lawrence, R., Eyre, S., Panoutsopoulou, K., Orozco, G., Elliott, K., Ke, X., Morris, A., UKRAG, U., Thomson, W., Worthington, J., Barton, A. & Zeggini, E (2010). Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis. Hum Genet, 128(6), 627-633. eScholarID:92370 | PMID:20852893 | DOI:10.1007/s00439-010-0889-1
  • Burr, ML, Naseem, H, Hinks, AM, Eyre, S, Gibbons, LJ, Bowes, J, BIRAC Consortium, YEAR Consortium, Wilson, AG, Maxwell, J, Morgan, AW, Emery, P, Steer, S, Hocking, L, Reid, DM, Wordsworth, B, Harrison, P, Thomson, W, Worthington, J, Barton, A. (2010). PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian Population. Ann Rheum Dis, 69(4), 666-670. eScholarID:1d19318 | DOI:10.1136/ard.2009.111294
  • Cui, et al (2010). Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy. Arthritis Rheum, 62(7), 1849-1861. eScholarID:78129 | PMID:20309874 | DOI:10.1002/art.27457
  • Elsby, L., Orozco, G., Denton, J., Worthington, J., Ray, D. & Donn, R (2010). Functional evaluation of TNFAIP3 (A20) in rheumatoid arthritis. Clin Exp Rheumatol, 28(5), 708-714. eScholarID:90085 | PMID:20822710
  • Eyre, S., Flynn, E., Martin, P., Hinks, A., Wilson, A., Morgan, A., Emery, P., Steer, S., Hocking, L., Reid, D., Harrison, P., Wordsworth, P., Thomson, W., Worthington, J. & Barton, A (2010). No evidence for association of the KLF12 gene with rheumatoid arthritis in a large UK cohort. Annals of the rheumatic diseases, 69(7), 1407-1408. eScholarID:78104 | PMID:19907058 | DOI:10.1136/ard.2009.120428
  • Eyre, S., Hinks, A., Bowes, J., Flynn, E., Martin, P., Wilson, A., Morgan, A., Emery, P., Steer, S., Hocking, L., Reid, D., Harrison, P., Wordsworth, P., Yorkshire_Early_Arthritis_(YEAR)_Consortium, Y., Biologics_in_RA_Control_(BIRAC)_Consortium, B., Thomson, W., Worthington, J. & Barton, A (2010). Overlapping genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease. Arthritis Res Ther, 12(5), R175. eScholarID:92369 | PMID:20854658 | DOI:10.1186/ar3139
  • Eyre, S., Hinks, A., Flynn, E., Martin, P., Wilson, A., Maxwell, J., Morgan, A., Emery, P., Steer, S., Hocking, L., Reid, D., Harrison, P., Wordsworth, P., Thomson, W., Worthington, J. & Barton, A (2010). Confirmation of association of the REL locus with rheumatoid arthritis susceptibility in the UK population. Annals of the rheumatic diseases, 69(8), 1572-1573. eScholarID:78103 | PMID:19945995 | DOI:10.1136/ard.2009.122887
  • Genetic_Analysis_of_Psoriasis_Consortium_&_the_Wellcome_Trust_Case_Control_Consortium_2, et al (2010). A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet, 42(11), 985-90. eScholarID:93928 | PMID:20953190 | DOI:10.1038/ng.694
  • Hassan, B., Maxwell, J., Hyrich, K., Biologics_in_Rheumatoid_Arthritis_Genetics_and_Genomics_Study_Syndicate, B., Barton, A., Worthington, J., Isaacs, J., Morgan, A. & Wilson, A (2010). Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis. Rheumatology (Oxford), 49(1), 43-7. eScholarID:76326 | PMID:19926672 | DOI:10.1093/rheumatology/kep372
  • Hinks, A., Eyre, S., Ke, X., Barton, A., Martin, P., Flynn, E., Packham, J., Worthington, J. & Thomson, W (2010). Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis. Annals of the Rheumatic Diseases, 69(6), 1049-1053. eScholarID:75055 | PMID:19674979 | DOI:10.1136/ard.2009.110650
  • Hinks, A., Eyre, S., Ke, X., Barton, A., Martin, P., Flynn, E., Packham, J., Worthington, J., Childhood_Arthritis_Prospective_Study, C., UKRAG_Consortium, U., BSPAR_Study_Group, B. & Thomson, W (2010). Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis. Genes Immun, 11(2), 194-198. eScholarID:76325 | PMID:20072139 | DOI:10.1038/gene.2009.105
  • Hinks, A., Martin, P., Flynn, E., Eyre, S., Packham, J., Arthritis_Prospective_Study_(CAPS), C., UKRAG, A., Barton, A., Worthington, J. & Thomson, W (2010). Association of the CCR5 gene with juvenile idiopathic arthritis. Genes Immun, 11(7), 584-589. eScholarID:82912 | PMID:20463745 | DOI:10.1038/gene.2010.25
  • Hinks, A., Martin, P., Flynn, E., Eyre, S., Packham, J., Barton, A., (CAPS), C., UKRAG, J., BSPAR_Study_Group, W., Worthington, J. & Thomson, W (2010). Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis. Ann Rheum Dis, 69(12), 2169-2172. eScholarID:88637 | PMID:20647273 | DOI:10.1136/ard.2009.126938
  • Liu, et al (2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet, 42(5), 436-40. eScholarID:80546 | PMID:20418889 | DOI:10.1038/ng.572
  • Morgan, A., Robinson, J., Conaghan, P., Martin, S., Hensor, E., Morgan, M., Steiner, L., Erlich, H., Gooi, H., Barton, A., Worthington, J., Emery, P., UKRAG_Consortium, U. & YEAR_Consortium, Y (2010). Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort. Arthritis Res Ther, 12(2), R57. eScholarID:78733 | PMID:20353580 | DOI:10.1186/ar2969
  • Orozco, GG, Eyre, SS, Hinks, AM, Ke, X, Wellcome Trust Case Control Consortium, YEAR Consortium, Wilson, A, Bax, D, Morgan, A, Emery, P, Steer, S, Hocking, L, Reid, D, Wordsworth, P, Harrison, P, Thomson, W, Barton, A, Worthington, J. (2010). Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study. Annals of the Rheumatic Diseases, 69(5), 813-816. eScholarID:1d19317 | DOI:10.1136/ard.2009.109579
  • Plant, D., Flynn, E., Mbarek, H., Dieudé, P., Cornelis, F., Arlestig, L., Dahlqvist, S., Goulielmos, G., Boumpas, D., Sidiropoulos, P., Johansen, J., Ornbjerg, L., Hetland, M., Klareskog, L., Filer, A., Buckley, C., Raza, K., Witte, T., Schmidt, R. & Worthington, J (2010). Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. Ann Rheum Dis, 69(8), 1548-1553. eScholarID:82913 | PMID:20498205 | DOI:10.1136/ard.2009.121020
  • Radstake, et al (2010). Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat Genet, 42(5), 426-9. eScholarID:82914 | PMID:20383147 | DOI:10.1038/ng.565
  • Stahl, et al (2010). Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nature genetics, 42(6), 508-514. eScholarID:80545 | PMID:20453842 | DOI:10.1038/ng.582
  • Wellcome Trust Case Control Consortium. (2010). Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature, 464(7289), 713. eScholarID:78732 | PMID:20360734 | DOI:10.1038/nature08979

2009

  • Barton, A, Eyre, S, Ke, X, Hinks, A, Bowes, J, Flynn, E, Martin, P, Wilson, A, Morgan, A, YEAR Consortium, BIRAC Consortium, Emery, P, Steer, S, Hocking, L, Reid, D, Harrison, P, Wordsworth, P, Thomson, W, Worthington, J. (2009). Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes. Human Molecular Genetics, 18(13), 2518. eScholarID:1d19073 | DOI:10.1093/hmg/ddp177
  • Barton, A. & Worthington, J (2009). Genetic susceptibility to rheumatoid arthritis: an emerging picture. Arthritis Rheum, 61(10), 1441-6. eScholarID:75052 | PMID:19790122 | DOI:10.1002/art.24672
  • Bowes, J, Potter, C, Gibbons, LJ, Hyrich, KL, Plant, D, BRAGGSS, Morgan, A, Wilson, A, Isaacs, J, Worthington, J, Barton, A. (2009). Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. Pharmacogenet Genomics, 19(4), 319-323. eScholarID:1d19079 | DOI:10.1097/FPC.0b013e328328d51f
  • Hafler, J, Maier, L, Cooper, J, Plagnol, V, Hinks, AM, Simmonds, M, Stevens, H, Walker, N, Healy, B, Howson, J, Maisuria, M, Duley, S, Coleman, G, Gough, S, International Multiple Sclerosis Genetics Consortium, Worthington, J, Kuchroo, V, Wicker, L, Todd, J. (2009). CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun, 10 (1)(1), 5-10. eScholarID:1d18218 | DOI:10.1038/gene.2008.82
  • Hinks, AM, Barton, A, Shephard, N, Eyre, S, Bowes, J, Cargill, M, Wang, E, Ke, X, BSPAR Study Group, Kennedy, G, John, S, Worthington, J, Thomson, W. (2009). Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis. Arthritis & Rheumatism, 60(1), 258. eScholarID:1d18276 | DOI:10.1002/art.24179
  • Hinks, AM, Ke, X, Barton, A, Eyre, S, Bowes, J, Worthington, J, UKRAG Consortium, BSPAR Study Group, Thompson, S, Langefeld, C, Glass, D, Thomson, W, NULL, NULL. (2009). Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis. Arthritis Rheum, 60( 1)(1), 251-257. eScholarID:1d18278 | DOI:10.1002/art.24187
  • McClure, A., Lunt, M., Eyre, S., Ke, X., Thomson, W., Hinks, A., Bowes, J., Gibbons, L., Plant, D., Wilson, A., Marinou, I., Morgan, A., Emery, P., BIRAC_Consortium, B., Steer, S., Hocking, L., Reid, D., Wordsworth, P., Harrison, P., Worthington, J. & Barton, A (2009). Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci. Rheumatology (Oxford), 48(11), 1369-1374. eScholarID:25700 | PMID:19741008 | DOI:10.1093/rheumatology/kep272
  • Morgan, A., Thomson, W., Martin, S., Carter, A., Erlich, H., Barton, A., Hocking, L., Reid, D., Harrison, P., Wordsworth, P., Steer, S., Worthington, J., Emery, P., Wilson, A. & Barrett, J (2009). Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population. Arthritis Rheum, 60(9), 2565-76. eScholarID:25724 | PMID:19714585 | DOI:10.1002/art.24752
  • Orozco, GG, Hinks, AM, Eyre, SS, Ke, X, Gibbons, LJ, Bowes, J, Flynn, EEM, Martin, P, Wellcome Trust Case Control Consortium, YEAR consortium, Wilson, A, Bax, D, Morgan, A, Emery, P, Steer, S, Hocking, L, Reid, D, Wordsworth, P, Harrison, P, Thomson, W, Barton, A, Worthington, J. (2009). Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23. Hum Mol Genet, 18(14), 2693-2699. eScholarID:1d19128 | DOI:10.1093/hmg/ddp193
  • Plant, D., Barton, B., Thomson, T., Ke, K., Eyre, E., Hinks, H., Bowes, B., Gibbons, G., Wilson, W., Marinou, M., Morgan, M., Steer, S., Hocking, H., Reid, R., Wordsworth, W., Harrison, H. & Worthington, W (2009). A re-evaluation of three putative functional single nucleotide polymorphisms in rheumatoid arthritis. Ann.Rheum.Dis, 68(8), 1373-1375. eScholarID:93680 | DOI:10.1136/ard.2008.103572
  • Potter, C, Hyrich, KL, Tracey, A, Lunt, M, Plant, D, Symmons, D, Thomson, W, Worthington, J, Emery, P, Morgan, A, Wilson, A, Isaacs, J, Barton, A, BRAGGSS. (2009). Association of RF and anti-CCP positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-TNF response in RA. Ann Rheum Dis, 68 (1), 69-74. eScholarID:1d17127 | DOI:10.1136/ard.2007.084715
  • Quaranta M, Burden AD, Griffiths CEM, Worthington J, Barker JN, Trembath RC, Capon F. (2009). Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes. Genes Immun, 10(7), 654-658. eScholarID:1d20233 | DOI:10.1038/gene.2009.51
  • Raychaudhuri, et al (2009). Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nature genetics, 41(12), 1313. eScholarID:75051 | PMID:19898481 | DOI:10.1038/ng.479
  • Rueda, B, Simeon, C, Hesselstrand, R, Herrick, AL, Worthington, J, Ortego-Centeno, N, Riemekasten, G, Fonollosa, V, Vonk, M, van den Hoogen, F, Sanchez-Román, J, Aguirre-Zamorano, M, García-Portales, R, Pros, A, Camps, M, Gonzalez-Gay, M, Coenen, M, Lambert, N, Nelson, J, Radstake, T, Martin, J. (2009). A large multicenter analysis of CTGF -945 promoter polymorphism does not confirm association with Systemic Sclerosis susceptibility or phenotype. Ann Rheum Dis, 68(10), 1618-1620. eScholarID:1d18215 | DOI:10.1136/ard.2008.100180
  • Smith, R., Warren, R., Griffiths, C. & Worthington, J (2009). Genetic susceptibility to psoriasis: an emerging picture. Genome Med, 1(7), 72. eScholarID:75056 | PMID:19638187 | DOI:10.1186/gm72
  • van der Woude D, Houwing-Duistermaat J, Toes R, Huizinga T, Thomson W, Worthington J, van der Helm-van Mil A, de Vries R. (2009). Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis. Arthritis Rheum, 60( 4), 916-23. eScholarID:1d19080 | DOI:10.1002/art.24385
  • Warren RB, Smith R, Campalani E, Eyre SS, Smith CH, Barker JN, Worthington J, Griffiths CEM. (2009). Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms. Br J Dermatol, 160 (2), 438-441. eScholarID:1d18204 | DOI:10.1111/j.1365-2133.2008.08898.x

2008

  • Ollier WER, Worthington J, Hochberg MC; SilmanA.J.; Smolen JS; Weinblatt ME; Weisman MH. (2008). Investigation of the genetic basis of rheumatic diseases. Rheumatology. ( 13, pp. 123-131). London: Elsevier. eScholarID:3d658
  • Ashworth JJ, Smyth JV, Pendleton N, Horan M A, Payton A, Worthington J, Ollier WER, Ashcroft GG. (2008). Polymorphisms spanning the 0N exon and promoter of the estrogen receptor-beta (ERbeta) gene ESR2 are associated with venous ulceration. Clin Genet, 73 (1), 55-61. eScholarID:1d16791
  • Barton, A, Thomson, W, Ke, X, Eyre, SS, Hinks, AM, Bowes, J, Gibbons, LJ, Plant, D, Wellcome Trust Case Control Consortium, Wilson, A, Marinou, I, Morgan, A, Emery, P, YEAR consortium, Steer, S, Hocking, L, Reid, D, Wordsworth, P, Harrison, P, Worthington, J. (2008). Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet, 17 (15), 2274 - 2279. eScholarID:1d17504 | DOI:10.1093/hmg/ddn128
  • Barton, A, Thomson, W, Ke, X, Eyre, SS, Hinks, AM, Bowes, J, Plant, D, Gibbons, LJ, Wellcome Trust Case Control Consortium, YEAR Consortium, BIRAC Consortium, Wilson, A, Bax, D, Morgan, A, Emery, P, Steer, S, Hocking, L, Reid, D, Wordsworth, P, Harrison, P, Worthington, J. (2008). Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature genetics, 40(10), 1156-9. eScholarID:1d18221 | DOI:10.1038/ng.218
  • Capon, F, Bijlmakers, M, Wolf, N, Quaranta, M, Huffmeier, U, Allen, M, Timms, K, Abkevich, V, Gutin, A, Smith, R, Warren, RB, Young, H, Worthington, J, Burden, A, Griffiths, C, Hayday, A, Nestle, F, Reis, A, Lanchbury, J, Barker, J, Trembath, R. (2008). Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. Human Molecular Genetics, 17(13), 1938-45. eScholarID:1d17544 | DOI:10.1093/hmg/ddn091
  • Filer C, Ho PY, Smith R, Griffiths CEM, Young H, Worthington J, Bruce IN, Barton A. (2008). Investigation of association of the IL12B and IL23R genes with psoriatic arthritis. Arthritis & Rheumatism, 58(12), 3705. eScholarID:1d18217 | DOI:10.1002/art.24128
  • Ho, PY, Barton, A, Worthington, J, Plant, D, Griffiths,C.E., Young,H.S., Bradburn, P, Thomson, W, Silman, AJ, Bruce, IN. (2008). Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis. Annals of the Rheumatic Diseases, 67(5), 677-682. eScholarID:1d16538 | DOI:10.1136/ard.2007.071399
  • Liu, Y, Helms, C, Liao, W, Zaba, L, Duan, S, Gardner, J, Wise, C, Miner, A, Malloy, M, Pullinger, C, Kane, J, Saccone, S, Worthington, J, Bruce, IN, Kwok, P, Menter, A, Krueger, J, Barton, A, Saccone, N, Bowcock, A. (2008). A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease Loci. PLoS Genet, 4 (3), eScholarID:1d17125 | DOI:10.1371/journal.pgen.1000041
  • Maxwell J, Potter C, Hyrich KL, Barton A, Worthington J, Isaacs J, Morgan A, Wilson A. (2008). Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis. Hum Mol Genet, 17 ( 22), 3532-8. eScholarID:1d18223 | DOI:10.1093/hmg/ddn245
  • Morgan A, Haroon-Rashid L, Martin S, Gooi H, Worthington J, Thomson W, Barrett J, Emery P. (2008). The shared epitope hypothesis in rheumatoid arthritis: evaluation of alternative classification criteria in a large UK Caucasian cohort. Arthritis Rheum, 58( 5), 1275-83. eScholarID:1d17511
  • NaseemH, Thomson W, Silman AJ, Worthington J, Symmons D, Barton A. (2008). The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome. Annals of the Rheumatic Diseases, 67(2), 251-5. eScholarID:1d16540 | DOI:10.1136/ard.2007.071894
  • Pushpakom SP, Herrick AL, Kumar S, Worthington J. (2008). Polymorphisms in COL15 Gene Are Not Associated with Systemic Sclerosis. J Rheumatol, 35(2), 251-3. eScholarID:1d16929
  • Raychaudhuri, et al. (2008). Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nature Genetics, 40(10), 1216-23. eScholarID:1d18219 | DOI:10.1038/ng.233
  • Smith, R., Warren, R., Eyre, S., Ke, X., Young, H., Allen, M., Strachan, D., McArdle, W., Gittins, M., Barker, J., Griffiths, C. & Worthington, J (2008). Polymorphisms in the PTPN22 region are associated with psoriasis of early onset. Br J Dermatol, 158(5), 962-8. eScholarID:85361 | PMID:18341666 | DOI:10.1111/j.1365-2133.2008.08482.x
  • Warren RB, Smith R, Campalani E, Eyre SS, Smith CH, Barker JN, Worthington J, Griffiths CEM. (2008). Genetic variation in efflux transporters influences outcome to methotrexate therapy in patients with psoriasis. J Invest Dermatol, 128 (8), 1925-1929. eScholarID:1d17073
  • Wolf, N, Quaranta, M, Prescott, N, Allen, M, Smith, R, Burden, A, Worthington, J, Griffiths, CEM, Mathew, C, Barker, J, Capon, F, Trembath, R. (2008). Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease. J Med Genet, 45 (2), 114-6. eScholarID:1d18197 | DOI:10.1136/jmg.2007.053595
  • Smith R, Warren RB, Eyre SS, Ho PY, Ke X, Young H, Griffiths CEM, Worthington J. (2008). Polymorphisms in the IL-12beta and IL-23R genes are associated with psoriasis of early onset in a UK cohort. J Invest Dermatol, 128( 5), eScholarID:17d699

2007

  • Amos, C., Chen, W., Remmers, E., Siminovitch, K., Seldin, M., Criswell, L., Lee, A., John, S., Shephard, N., Worthington, J., Cornelis, F., Plenge, R., Begovich, A., Dyer, T., Kastner, D. & Gregersen, P (2007). Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits. BMC Proc, 1 Suppl 1(Suppl 1), S3. eScholarID:54297 | PMID:18466527 | DOI:10.1186/1753-6561-1-s1-s3
  • Barrett, J., Sheehan, N., Cox, A., Worthington, J., Cannings, C. & Teare, M (2007). Family based studies and genetic epidemiology: theory and practice. Hum Hered, 64(2), 146-8. eScholarID:54324 | PMID:17476114 | DOI:10.1159/000101993
  • Burton,P.R., et al. (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics, 39 (11), eScholarID:1d16536 | DOI:10.1038/ng.2007.17
  • Donn, RP, Berry, A, Stevens, A, Farrow, S, Betts, J, Stevens, R, Clayton, C, Wang, J, Warnock, L, Worthington, J, Scott, L, Graham, S, Ray, DW. (2007). Use of gene expression profiling to identify a novel glucocorticoid sensitivity determining gene, BMPRII. FASEB J, 21( 2), 402-14. eScholarID:1d15649 | DOI:10.1096/fj.06-7236com
  • Feitsma, A, Worthington, J, van der Helm-van Mil, A, Plant, D, Thomson, W, Ursum, J, van Schaardenburg, D, van der Horst-Bruinsma, I, van Rood, J, Huizinga, T, Toes, R, de Vries, R. (2007). Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development. Proc Natl Acad Sci U S A, 104( 50), 19966-70. eScholarID:1d16801 | DOI:10.1073/pnas.0710260104
  • Hinks AM, Eyre SS, Barton A, Thomson W, Worthington J. (2007). Investigation of genetic variation across PTPN22 in UK rheumatoid arthritis (RA) patients. Ann Rheum Dis, 66(5), 683-6. eScholarID:1d14393
  • Ho PY, Barton A, Worthington J, Thomson W, Silman AJ, Bruce IN. (2007). HLA-Cw6 and HLA-DRB1*07 together are associated with less severe joint disease in psoriatic arthritis. Ann Rheum Dis, 66, 6, 807 - 811. eScholarID:1d15653
  • Potter C, Eyre SS, Cope A, Worthington J, Barton A. (2007). Investigation of association between the TRAF family genes and RA susceptibility. Ann Rheum Dis, 66, 10, 1322 -1326. eScholarID:1d15651
  • Thomson, W, Barton, A, Ke, X, Eyre, SS, Hinks, AM, Bowes, J, Donn, RP, Symmons, D, Hider, SL, Bruce, IN, The Wellcome Trust Case Control Consortium, Wilson, A, Marinou, I, Morgan, A., Emery, P., YEAR Consortium, Carter, A., Steer, S., Hocking, L., Reid, D. M., Wordsworth, P., Harrison, P. , Strachan, D., Worthington, J. (2007). Rheumatoid arthritis association at 6q23. Nature Genetics, 39 (12), 1431-1433. eScholarID:1d16027 | DOI:10.1038/ng.2007.32
  • Wellcome Trust Case Control Consortium. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447(7145), 661-678. eScholarID:1d16024 | DOI:10.1038/nature05911
  • Ho PY, Worthington J, Bruce IN, Barton A. (2007). Investigation of association of the DLG5 gene with psoriatic arthritis. Ann Rheum Dis, 66( 2), 273-4. eScholarID:17d955

2006

  • Eyre SS, Bowes J, Potter C, Worthington J, Barton A. (2006). Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity? Arthritis Res Ther, 8( 4), eScholarID:1d14291
  • Eyre SS, Bowes J, Spreckley KB, Potter C, Ring S, Strachan D, Worthington J, Barton A. (2006). Investigation of the MHC2TA gene, associated with rheumatoid arthritis in a Swedish population, in a UK rheumatoid arthritis cohort. Arthritis Rheum, 54( 11), 3417-22. eScholarID:1d14287 | DOI:10.1002/art.22166
  • Hinks AM, Barton A, John S, Shephard N, Worthington J. (2006). Fine mapping of genes within the IDDM8 region in rheumatoid arthritis. Arthritis Res Ther, 8( 5), eScholarID:1d14289
  • Hinks AM, Worthington J, Thomson W. (2006). The association of PTPN22 with rheumatoid arthritis and juvenile idiopathic arthritis. Rheumatology (Oxford), 45( 4), 365-8. eScholarID:1d14292
  • John, S, Amos,C., Shephard, N, Chen,W., Butterworth,A., Etzel,C., Jawaheer,D., Seldin,M., Silman, AJ, Gregersen,P., Worthington, J. (2006). Linkage analysis of rheumatoid arthritis in US and UK families reveals interactions between HLA-DRB1 and loci on chromosomes 6q and 16p. Arthritis and Rheumatism, 54, 5, 1482-1490. eScholarID:1d14265 | DOI:10.1002/art.21794
  • Payton A, Horan M A, Davidson YS, Gibbons LC, Ollier WER, Rabbitt P-, Worthington J, Pendleton N, Pendleton N. (2006). Influence and interactions of cathepsin D, HLA-DRB1 and APOE on cognitive abilities in an older non-demented population. Genes Brain and Behavior, 5, Suppl 1, 23-31. eScholarID:1d11375 | DOI:10.1111/j.1601-183X.2006.00191.x
  • Plant D, Watson REB, Young H, Worthington J, Griffiths CEM. (2006). The CX3CL1-CX3CR1 system and psoriasis. Experimental Dermatology, 15 (11), 900-903. eScholarID:1d13538

2005

  • Stephens, RH, McElduff, P, Worthington, J, Ollier, WER, New, JP, Payton, A, Pendleton, N, Horan, M A, Cruickshank, (K, Gibson, JM. (2005). Single-nucleotide polymorphisms (SNPs) in the IGFBP1 gene are associated with diabetes risk and nephropathy in a cohort of type 2 diabetes mellitus patients. eScholarID:2d2022
  • Ashworth J J, Smyth J Vincent, Pendleton N, Horan M A, Payton A, Worthington J, Ollier WER, Ashcroft GG. (2005). The dinucleotide (CA)repeat polymorphism of estrogen receptor beta but not the dinulclotide (TA)repeat polymorphism of estrogen receptor alpha is associated with venous ulceration. J Steroid Biochem Mol Biol, 97(3), 266-70. eScholarID:1d11193
  • Barton A, Bowes J, Eyre SS, Symmons D, Worthington J, Silman AJ. (2005). Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis. Ann Rheum Dis, 64( 9), 1311-5. eScholarID:1d11759
  • Barton A, Eyre SS, Bowes J, Ho PY, John S, Worthington J. (2005). Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patients. Arthritis Rheum, 52( 3), 752-8. eScholarID:1d11757 | DOI:10.1002/art.20877
  • Gibbons LJ, Thomson W, Zeggini E, Worthington J, Barton A, Eyre SS, Donn RP, Hinks AM. (2005). The type 1 diabetes susceptibility gene SUMO4 at IDDM5 is not associated with susceptibility to rheumatoid arthritis or juvenile idiopathic arthritis. Rheumatology (Oxford), 44( 11), 1390-3. eScholarID:1d11753 | DOI:10.1093/rheumatology/kei041
  • Hinks, AM, Barton, A, John, S, Bruce, IN, Hawkins, C, Griffiths, CEM, Donn, RP, Thomson, W, Silman, AJ, Worthington, J. (2005). Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene. Arthritis Rheum, 52( 6), 1694-9. eScholarID:1d11755 | DOI:10.1002/art.21049
  • Ho, PY, Bruce, IN, Silman, AJ, Symmons, D, Newman, WG, Young, H, Griffiths, CEM, John, S, Worthington, J, Barton, A. (2005). Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis. Arthritis Rheum, 52( 11), 3596-3602. eScholarID:1d11751 | DOI:10.1002/art.21393
  • Karasneh J, Gul A, Ollier WER, Silman AJ, Worthington J. (2005). Whole-genome screening for susceptibility genes in multicase families with Behcet's disease. Arthritis Rheum, 52( 6), 1836-42. eScholarID:1d11717
  • Karasneh J, Hajeer A, Silman AJ, Worthington J, Ollier WER, Gul A. (2005). Polymorphisms in the endothelial nitric oxide synthase gene are associated with Behcet's disease. Rheumatology (Oxford), 44( 5), 614-7. eScholarID:1d11724
  • Payton A, Gibbons LC, Davidson YS, Ollier WER, Rabbitt P-, Worthington J, Pickles A, Pendleton N, Horan M A. (2005). Influence of serotonin transporter gene polymorphisms on cognitive decline and cognitive abilities in a nondemented elderly population. Molecular Psychiatry, 10(12), 1133-1139. eScholarID:1d11213 | DOI:10.1038/sj.mp.4001733
  • Stephens RH, McElduff P, Heald A, New JP, Worthington J, Ollier WER, Gibson JM. (2005). Polymorphisms in insulin-like growth factor-binding protein 1 are associated with impaired renal function in Type-2 diabetes mellitus. Diabetes, 54(12), 3547-53. eScholarID:1d11934 | DOI:10.2337/diabetes.54.12.3547
  • Stevenson J, Langley K, Pay H, Payton A, Worthington J, Ollier WER, Thapar A. (2005). Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. J Child Psychol Psychiatry, 46(10), 1081-8. eScholarID:1d11712
  • ZegginiE, Barton A, Eyre SS, WardD, Ollier WER, Worthington J, John S. (2005). Characterisation of the genomic architecture of human chromosome 17q and evaluation of different methods for haplotype block definition. BMC Genet, 6, 1, eScholarID:1d11173

2004

  • Barton A, Bowes J, Eyre SS, Spreckley KB, Hinks AM, John S, Worthington J. (2004). A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population. Arthritis and Rheumatism, 50, 4, 1117 - 1121. eScholarID:1d8157 | DOI:10.1002/art.20169
  • Barton A, Jury F, Eyre SS, Bowes J, Hinks AM, WardD, Worthington J. (2004). Haplotype analysis in simplex families and novel analytic approaches in a case-control cohort reveal no evidence of association of the CTLA-4 gene with rheumatoid arthritis. Arthritis and Rheumatism, 50, 3, 748 - 752. eScholarID:1d8161
  • Barton A, PlattH, SalwayF, Symmons D, Lunt M, Worthington J, Silman AJ. (2004). Polymorphisms in the Mannose Binding Lectin (MBL) Gene Are Not Associated with Radiographic Erosions in Rheumatoid or Inflammatory Polyarthritis. Journal of Rheumatology, 31, 3, 442 - 447. eScholarID:1d8163
  • Barton, A, Barton, A, Platt, H, Salway, F, Symmons, D, Barrett, EM, Bukhari, MAS, Lunt, M, Zeggini, E, Eyre, SS, Hinks, AM, Tellam, DJ, Brintnell, W, Ollier, WER, Worthington, J, Silman, AJ. (2004). Polymorphisms in the tumour necrosis factor gene are not associated with severity of inflammatory polyarthritis. Ann Rheum Dis, 63, 3, 280-284. eScholarID:1d9454 | DOI:10.1136/ard.2003.008680
  • Barton, A, Woolmore,J.A., Ward,D., Eyre, SS, Hinks, AM, Ollier, WER, Strange,R.C., Fryer,A.A., John, S, Hawkins,C.P., Worthington, J. (2004). Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population. Brain, 127, 8, 1717-1722. eScholarID:1d8159 | DOI:10.1093/brain/awh193
  • Brintnell W, Zeggini E, Barton A, Thomson W, Eyre SS, Hinks AM, Silman AJ, Worthington J. (2004). Evidence for a novel rheumatoid arthritis susceptibility locus on chromosome 6p. Arthritis and Rheumatism, 50, 12, 3823-3830. eScholarID:1d9471
  • Donn RP, Plant D, Jury F, Richards HL, Worthington J, Ray DW, Griffiths CEM. (2004). Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis. Journal of Investigative Dermatology, 123, 484-487. eScholarID:1d7891 | DOI:10.1111/j.0022-202X.2004.23314.x
  • Eyre, SS, Barton, A, Shephard, N, Hinks, AM, Brintnell, W, MacKay,K., Silman, AJ, Ollier, WER, Wordsworth,P., John, S, Worthington, J. (2004). Investigation of susceptibility loci identified in the UK rheumatoid arthritis whole-genome scan in a further series of 217 UK affected sibling pairs. Arthritis and Rheumatism, 50, 3, 729-735. eScholarID:1d8165 | DOI:10.1002/art.20039
  • John, S, Shephard, N, Liu, G, Zeggini, E, Cao, M, Chen, W, Vasavda, N, Barton, A, Hinks, AM, Eyre, SS, Jones, K, Ollier, WER, Silman, AJ, Gibson, N, Worthington, J, Kennedy, G. (2004). Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites. Am J Hum Genet, 75( 1), 54-64. eScholarID:1d8131 | DOI:10.1086/422195
  • Kilding R, Iles M, Timms J, Worthington J, Wilson A. (2004). Additional genetic susceptibility for rheumatoid arthritis telomeric of the DRB1 locus. Arthritis Rheum, 50( 3), 763-9. eScholarID:1d8183
  • Plant D, Lear JT, A Marsland, Worthington J, Griffiths CEM. (2004). CARD15/NOD2 single nucleotide polymorphisms do not confer susceptibility to type 1 psoriasis. British Journal of Dermatology, 151, 3, 675-8. eScholarID:1d7734

2003

  • ShepherdN, Falcaro M, Zeggini E, ChapmanP, Hinks AM, Barton A, Worthington J, Pickles A, John S. (2003). Linkage and association analysis of alternative phenotypic measures to identify loci influencing blood pressure. eScholarID:2d872
  • Barton A, LambR, Symmons D, Silman AJ, Thomson W, Worthington J, Donn RP. (2003). Macrophage migration inhibitory factor (MIF) gene polymorphism is associated with susceptibility to but not severity of inflammatory polyarthritis. Genes and Immunity, 4, 487-491. eScholarID:1d5642 | DOI:10.1038/sj.gene.6364014
  • Langley,K., Payton, A, Hamshere,M.L., Pay,H.M., Lawson,D.C., Turic,D., Ollier, WER, Worthington, J, Owen,M.J., O'Donovan,M.C., Thapar,A. (2003). No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatric Genetics, 13, 2, 107-110. eScholarID:1d5783 | DOI:10.1097/01.ypg.0000056177.32550.a5
  • Morgan,A.W., Keyte,V.H., Babbage,S.J., Robinson,J.I., Ponchel,F., Barrett,J.H., Bhakta,B.B., Bingham,S.J., Buch,M.H., Conaghan,P.G., Gough,A., Green,M., Lawson,C.A., Pease,C.T., Markham,A.F., Ollier, WER, Emery,P., Worthington, J, Isaacs,J.D. (2003). FcgammaRIIIA-158V and rheumatoid arthritis: a confirmation study. Rheumatology, 42, 4, 528-533. eScholarID:1d5792 | DOI:10.1093/rheumatology/keg169
  • Payton, A, Holland,F., Diggle, P., Rabbitt, P-, Horan, M A, Davidson, YS, Gibbons, LC, Worthington, J, Ollier, WER, Pendleton, N. (2003). Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population. Molecular Psychiatry, 8, 1, 14-18. eScholarID:1d5796 | DOI:10.1038/sj.mp.4001239
  • Payton, A, Turic, D, Langley, K, Mills, S, Lawson, D, Van den Bree, M, Owen, M, O'Donovan, M, Ollier, WER, Worthington, J, Thapar, A. (2003). No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder. Psychiatr Genet, 13( 3), 183-5. eScholarID:1d8104 | DOI:10.1097/00041444-200309000-00009
  • Shephard N, Falcaro M, Zeggini E, ChapmanP, Hinks AM, Barton A, Worthington J, Pickles A, John S. (2003). Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure. BMC Genetics, 4 Suppl 1, eScholarID:1d26143
  • Worthington J, John S. (2003). Association of PADI4 and rheumatoid arthritis - a successful multidisciplinary approach. Trends in Molecular Medicine, 9 (10), 405-407. eScholarID:1d5654
  • John S, SmithS, MorrisonJ.F, Symmons D, Worthington J, Silman AJ, Barton A. (2003). Genetic variation in the cytokine chemokine receptor 5 (CCR5) does not predict clinical outcome in inflammatory polyarthritis. Arthritis and Rheumatism, 48(12), 3615-3616. eScholarID:17d394
  • StricklandP.L, John S, Payton A, Worthington J, Ollier WER, Deakin JFW. (2003). Do genetic polymorphisms of serotonin (5-HT) neurotransmission influence function in humans? American Journal of Medical Genetics, 120A(4), 566-567. eScholarID:17d816

2002

  • Barton A, Worthington J. (2002). Commentary on "Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus", by RR Graham et al. Arthritis Res, 4, 2, 84-86. eScholarID:1d5739
  • Fife,M., Steer,S., Fisher,S., Newton,J., McKay,K., Worthington, J, Shah,C., Polley,A., Rosenthal,A., Ollier, WER, Lewis,C., Wordsworth,P., Lanchbury,J. (2002). Association of familial and sporadic rheumatoid arthritis with a single corticotropin-releasing hormone genomic region (8q12.3) haplotype. Arthritis and Rheumatism, 46, 1, 75-82. eScholarID:1d5643 | DOI:10.1002/1529-0131(200201)46:1<75::AID-ART10034>3.0.CO;2- 3
  • Herrick AL, Worthington J. (2002). Genetic epidemiology: systemic sclerosis. Arthritis Res, 4, 3, 165-168. eScholarID:1d5612
  • Holmes,J., Payton, A, Barrett,J., Harrington,R., McGuffin,P., Owen,M., Ollier, WER, Worthington, J, Gill,M., Kirley,A., Hawi,Z., Fitzgerald,M., Asherson,P., Curran,S., Mill,J., Gould,A., Taylor,E., Kent,L., Craddock,N., Thapar,A. (2002). Association of DRD4 in children with ADHD and comorbid conduct problems. American Journal of Medical Genetics, 114, 2, 150-153. eScholarID:1d5780 | DOI:10.1002/ajmg.10149
  • MacKay,K., Eyre, SS, Myerscough,A., Milicic,A., Barton, A, Laval,S., Barrett,J., Lee,D., White,S., John, S, Brown,M.A., Bell,J., Silman, AJ, Ollier, WER, Wordsworth,P., Worthington, J. (2002). Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom. Arthritis and Rheumatism, 46, 3, 632 - 639. eScholarID:1d3669 | DOI:10.1002/art.10147
  • Pendleton N, Payton A, van den BoogerdE.H, HollandF, DiggleP, RabbittP.M, Horan M A, Worthington J, Ollier WER. (2002). Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults. Neuroscience Letters, 324, 1, 74-76. eScholarID:1d5651

2001

  • Barton A, ChapmanP, Myerscough A, PinelT, Hinks AM, DaviesN, Worthington J, John S. (2001). The single-nucleotide polymorphism lottery: how useful are a few common SNPs in identifying disease-associated alleles? Genetic Epidemiology, 21, Suppl. 1, S384 - S389. eScholarID:1d3626
  • Barton A, John S, Ollier WER, Silman AJ, Worthington J. (2001). Association between rheumatoid arthritis and polymorphism of tumor necrosis factor receptor II, but not tumor necrosis factor receptor I, in Caucasians. Arthritis and Rheumatism, 44, 1, 61 - 65. eScholarID:1d3737
  • Barton, A, Eyre, SS, Myerscough,A., Brintnell,B., Ward,D., Ollier, WER, Lorentzen,J.C., Klareskog,L., Silman, AJ, John, S, Worthington, J, The Arthritis Rheumatism Campaign National Repository. (2001). High resolution linkage and association mapping identifies a novel rheumatoid arthritis susceptibility locus homologous to one linked to two rat models of inflammatory arthritis. Human Molecular Genetics, 10 (18), 1901 - 1906. eScholarID:1d3624 | DOI:10.1093/hmg/10.18.1901
  • GulA, HajeerA.H, Worthington J, BarrettJ.H, Ollier WER, Silman AJ. (2001). Evidence for linkage of the HLA-B locus in Behcet's disease, obtained using the transmission disequilibrium test. Arthritis and Rheumatism, 44, 1, 239-240. eScholarID:1d5645 | DOI:10.1002/1529-0131(200101)44:1<239::AID-ANR31>3.0.CO;2- X
  • GulA, HajeerA.H, Worthington J, Ollier WER, Silman AJ, Silman AJ. (2001). Linkage mapping of a novel susceptibility locus for Behcet's disease to chromosome 6p22-23. Arthritis and Rheumatism, 44, 11, 2693-2696. eScholarID:1d5647 | DOI:10.1002/1529-0131(200111)44:11<2693::AID-ART449>3.0.CO;2- M
  • John S, Eyre SS, MyerscoughA, BarrettJ, Silman AJ, Ollier WER, Worthington J. (2001). Linkage and association analysis of candidate genes in rheumatoid arthritis. Journal of Rheumatology, 28, 8, 1752-1755. eScholarID:1d3555
  • John S, Worthington J. (2001). Genetic epidemiology. Approaches to the genetic analysis of rheumatoid arthritis. Arthritis Res, 3, 4, 216-220. eScholarID:1d5649
  • Payton, A, Holmes,J., Barrett,J.H., Hever,T., Fitzpatrick,H., Trumper,A.L., Harrington,R., McGuffin,P., O'Donovan,M., Owen,M., Ollier, WER, Worthington, J, Thapar,A. (2001). Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: a family-based study. American Journal of Medical Genetics, 105, 5, 464-470. eScholarID:1d5797 | DOI:10.1002/ajmg.1407
  • Payton, A, Holmes,J., Barrett,J.H., Sham,P., Harrington, R, McGuffin,P., Owen,M., Ollier, WER, Worthington, J, Thapar,A. (2001). Susceptibility genes for a trait measure of attention deficit hyperactivity disorder: a pilot study in a non-clinical sample of twins. Psychiatry Research, 105, 3, 273-278. eScholarID:1d5799 | DOI:10.1016/S0165-1781(01)00342-0
  • Stevens A, Ray DW, Worthington J, Davis JRE. (2001). Polymorphisms of the human prolactin gene--implications for production of lymphocyte prolactin and systemic lupus erythematosus. Lupus, 10, 676-683. eScholarID:1d19277 | DOI:10.1191/096120301717164903
  • Stevens F, Ray DW, Alansari A, Hajeer A, Thomson W, Donn RP, Ollier WER, Worthington J, Davis JRE. (2001). Characterization of a prolactin gene polymorphism and its associations with systemic lupus erythematosus. Arthritis Rheum, 44( 10), 2358-66. eScholarID:1d15733
  • Weatherby,S.J., Thomson, W, Pepper,L., Donn, RP, Worthington, J, Mann,C.L., Davies,M.B., Fryer,A.A., Boggild,M.D., Young,C.A., Jones,P.W., Strange,R.C., Ollier, WER, Hawkins,C.P. (2001). HLA-DRB1 and disease outcome in multiple sclerosis. Journal of Neurology, 248, 4, 304-310. eScholarID:1d5652 | DOI:10.1007/s004150170205

2000

  • Barton A, MyerscoughA, John S, Gonzalez-GayM, Ollier WER, Worthington J. (2000). A single nucleotide polymorphism in exon 1 of cytotoxic T-lymphocyte-associated-4 (CTLA-4) is not associated with rheumatoid arthritis. Rheumatology, 39, 1, 63 - 66. eScholarID:1d3622
  • FifeM.S, FisherS.A, John S, Worthington J, ShahC.J, Ollier WER, PanayiG.S, LewisC.M, LanchburyJ.S. (2000). Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region. Arthritis and Rheumatism, 43, 8, 1673 - 1678. eScholarID:1d3549
  • MyerscoughA, John S, BarrettJ.H, Ollier WER, Worthington J. (2000). Linkage of rheumatoid arthritis to insulin-dependent diabetes mellitus loci: evidence supporting a hypothesis for the existence of common autoimmune susceptibility loci. Arthritis and Rheumatism, 43, 12, 2771 - 2775. eScholarID:1d3679
  • SusolE, MacGregorA.J, BarrettJ.H, WilsonH, BlackC, WelshK, Silman AJ, Ollier WER, Worthington J. (2000). A two-stage, genome-wide screen for susceptibility loci in primary Raynaud's phenomenon. Arthritis and Rheumatism, 43, 7, 1641 - 1646. eScholarID:1d3685
  • SusolE, RandsA.L, HerrickA, McHughN, BarrettJ.H, Ollier WER, Worthington J. (2000). Association of markers for TGFbeta3, TGFbeta2 and TIMP1 with systemic sclerosis. Rheumatology, 39, 12, 1332 - 1336. eScholarID:1d3739

1999

  • Cox,A., Camp,N.J., Cannings,C., di Giovine,F.S., Dale,M., Worthington, J, John, S, Ollier, WER, Silman, AJ, Duff,G.W. (1999). The Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis. Human Molecular Genetics, 8, 9, eScholarID:1d3547
  • Donn RP, Farhan A, Barrett J, Thomson W, Worthington J, Ollier Bill. (1999). Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients. Rheumatology (Oxford), 38( 2), eScholarID:1d21646
  • John S, MyerscoughA, Eyre SS, RobyP, HajeerA, Silman AJ, Ollier WER, Worthington J. (1999). Linkage of a marker in intron D of the estrogen synthase locus to rheumatoid arthritis. Arthritis and Rheumatism, 42, 8, eScholarID:1d3553

  • López-Isac, E., Bossini-Castillo, L., Simeon, C., Egurbide, M., Alegre-Sancho, J., Callejas, J., Roman-Ivorra, J., Freire, M., Beretta, L., Santaniello, A., Airó, P., Lunardi, C., Hunzelmann, N., Riemekasten, G., Witte, T., Kreuter, A., Distler, J., Schuerwegh, A., Vonk, M., Voskuyl, A., Shiels, P., van Laar, J., Fonseca, C., Denton, C., Herrick, A., Worthington, J., Assassi, S., Koeleman, B., Mayes, M., Radstake, T. & Martin, J A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility. Arthritis Res Ther, 16(1), R6. eScholarID:218658 | PMID:24401602 | DOI:10.1186/ar4432

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