Professor Jane Worthington PhD

Photograph of Jane Worthington

Professor of Chronic Disease Genetics

  • Email:
  • Telephone: +44 (0)161 275 5651
  • Alternative Telephone: +44 (0)161 306 0692 (Shirley Thomasson - PA to ID)
  • Fax: +44 (0)161 275 5043

Institute of Inflammation and Repair
The University of Manchester
Room 2.527/28 Stopford Building
University of Manchester
Oxford Road
M13 9PT


Professor of Chronic Disease Genetics

Director, Institute of Inflammation and Repair

Lead, Arthritis Research UK Centre for Genetics and Genomics

Research Theme Lead for Prevention of disease and the complications of treatment, NIHR Manchester Musculoskeletal Biomedical Research Unit

Honorary Research Principal Investigator, Central Manchester & Manchester Children's University Hospital, NHS Trust

I&R Domain, Academic Lead, Manchester Academic Health Science Centre Manchester


Genetics and genomics: studies on the genetic contribution to a range of rheumatological disorders but with a specific focus on inflammatory joint disease. More

I am Research Theme Lead for the Prevention of disease and the complications of treatment research at the NIHR Manchester Musculoskeletal Biomedical Research Unit .




  • Han, B., Pouget, J. G., Slowikowski, K., Stahl, E., Lee, C. H., Diogo, D., ... Raychaudhuri, S. (2016). A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nature Genetics, 48(7), 803 - 810. DOI:10.1038/ng.3572. Publication link: d7bd7cb4-db9f-429e-82e1-f4dcb1ba5068
  • Márquez, A., Vidal-Bralo, L., Rodríguez-Rodríguez, L., González-Gay, M. A., Balsa, A., González-álvaro, I., ... Martín, J. (2016). A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus. Annals of the Rheumatic Diseases. DOI:10.1136/annrheumdis-2016-209436. Publication link: cb95b875-ca71-4a10-a604-eb53f43da98c
  • Plant, D., Webster, A., Nair, N., Oliver, J., Smith, S. L., Eyre, S., ... Barton, A. (2016). Differential methylation as a biomarker of response to etanercept in patients with rheumatoid arthritis. Arthritis & Rheumatism, 68(6), 1353–1360. DOI:10.1002/art.39590. Publication link: d1a7db48-ab2d-45f8-8487-edb824eac51d
  • Smith, R. L., Hébert, H. L., Massey, J., Bowes, J., Marzo-Ortega, H., Ho, P., ... Warren, R. B. (2016). Association of Toll-like receptor 4 (TLR4) with chronic plaque type psoriasis and psoriatic arthritis. Archives of Dermatological Research, 308(3), 201-205. DOI:10.1007/s00403-016-1620-4. Publication link: 1f976e46-e5d6-43ca-9d36-50c22f1e45dd | PubMed:26830904
  • Viatte, S., Massey, J., Bowes, J., Duffus, K., arcOGEN Consortium, Eyre, S., ... Worthington, J. (2016). Replication of genetic loci outside the HLA conferring susceptibility to anti-CCP negative rheumatoid arthritis.Arthritis & Rheumatology, 68(7), 1160-6. DOI:10.1002/art.39619. Publication link: a8ee9dec-8f02-4f3b-b46f-3586ea069ab9 | PubMed:26895230
  • Wei, W., Bowes, J., Plant, D., Viatte, S., Yarwood, A., Massey, J., ... Eyre, S. (2016). Major histocompatibility complex harbors widespread genotypic variability of 2 non-additive risk of rheumatoid arthritis including epistasis. Scientific Reports, 6, [25014]. DOI:10.1038/srep25014. Publication link: 70c6b9a5-135b-4a46-be16-f435a0c466e2
  • Wei, W-H., Loh, C-Y., Worthington, J., & Eyre, S. (2016). Immunochip analyses of epistasis in rheumatoid arthritis confirm multiple interactions within MHC and suggest novel non-MHC epistatic signals.The Journal of rheumatology, 43(5), 839-845. DOI:10.3899/jrheum.150836. Publication link: e26345c8-1256-42a4-b6b1-0164320a7655 | PubMed:26879349
  • Yarwood, A., Eyre, S., & Worthington, J. (2016). Genetic susceptibility to rheumatoid arthritis and its implications for novel drug discovery.Expert Opinion on Drug Discovery. . Publication link: 896d6734-35b3-4f67-8f8d-2f9312d40543
  • Yarwood, A., Huizinga, T. W., & Worthington, J. (2016). The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA. Rheumatology (Print), 55(2), 199-209. . Publication link: 23aaec46-eac1-43a8-b2e1-c01bdac6760f
  • Yarwood, A., Viatte, S., Okada, Y., Plenge, R., Yamamoto, K., BRAGGSS, ... Eyre, S. (2016). Loci associated with N-glycosylation of human IgG are not associated with rheumatoid arthritis: A Mendelian randomisation study.Annals of the Rheumatic Diseases, 75(1), 317-20. DOI:10.1136/annrheumdis-2014-207210. Publication link: f39db358-92a0-480d-9c12-58d39222cb06


  • Ding, J., Eyre, S., & Worthington, J. (2015). Genetics of RA susceptibility, what comes next?. RMD Open, 1(1), [e000028]. DOI:10.1136/rmdopen-2014-000028. Publication link: d7a01cec-490b-48f4-a4dd-38fc94686bfa
  • Fortune, M. D., Guo, H., Burren, O., Schofield, E., Walker, N. M., Ban, M., ... Wallace, C. (2015). Statistical Colocalization of Genetic Risk Variants for Related Autoimmune Diseases in the Context of Common Controls. Nature Genetics, 47(7). DOI:10.1038/ng.3330. Publication link: 3e5ea8cd-8450-473c-9389-a82af82a85a3 | PubMed:26053495
  • Kim, K., Bang, S-Y., Lee, H-S., Cho, S-K., Choi, C-B., Sung, Y-K., ... Bae, S-C. (2015). High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.Annals of the rheumatic diseases, 74, e13. DOI:10.1136/annrheumdis-2013-204749. Publication link: ef306f0d-2ac7-4209-a482-85b15f6040f1 | PubMed:24532676
  • Lee, S. H., Byrne, E. M., Hultman, C. M., Kähler, A., Vinkhuyzen, A. A., Ripke, S., ... van Riel, P. (2015). New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. International Journal of Epidemiology, 44(5), 1706-1721. DOI:10.1093/ije/dyv136. Publication link: 97b3871f-785e-4537-80a4-18330b1c8703 | PubMed:26286434
  • Lenz, T. L., Deutsch, A. J., Han, B., Hu, X., Okada, Y., Eyre, S., ... Raychaudhuri, S. (2015). Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.Nature Genetics, 47(9), 1085-1090. DOI:10.1038/ng.3379. Publication link: 9a133c92-0710-42b6-b37b-68ecc036f7ed | PubMed:26258845
  • López-Isac, E., Campillo-Davo, D., Bossini-Castillo, L., Guerra, S. G., Assassi, S., Simeón, C. P., ... Oreiro, N. (2015). Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway.Annals of the rheumatic diseases. DOI:10.1136/annrheumdis-2015-208154. Publication link: c02241a4-87a1-46e3-b8d9-5f19427cbf63 | PubMed:26338038
  • Martin, P., Eyre, S., Barton, A., Duffus, K., Orozco, G., Worthington, J., ... Fraser, P. (2015). Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci. Nature communications, 6, [10069]. DOI:10.1038/ncomms10069. Publication link: 0d9a67a2-39d4-4fd1-a442-20b62d916fdf
  • Ochoa, E., Martin, J-E., Assasi, S., Beretta, L., Carreira, P., Guillén, A., ... The Spanish Scleroderma Group, A. (2015). Confirmation of CCR6 as a risk factor for anti-topoisomerase I antibodies in systemic sclerosis.Clinical and Experimental Rheumatology, 33 Suppl 91(4). . Publication link: 6abce57e-acda-4eea-b195-629b8db8070b | PubMed:26314374
  • Viatte, S., Plant, D., Han, B., Fu, B., Yarwood, A., Thomson, W., ... Barton, A. (2015). Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.JAMA, 313(16), 1645-1656. DOI:10.1001/jama.2015.3435. Publication link: b882366e-0899-4461-9fbe-e64430a95f28 | PubMed:25919528
  • Yarwood, A., Han, B., Raychaudhuri, S., Bowes, J., Lunt, M., Pappas, D. A., ... Eyre, S. (2015). A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk. Annals of the Rheumatic Diseases, 74(1), 170-176. DOI:10.1136/annrheumdis-2013-204133. Publication link: e1cf45d5-af36-4757-afbd-7b1cbd3cde8d | PubMed:24092415


  • Banka, S., Cain, S. A., Carim, S., Daly, S. B., Urquhart, J. E., Erdem, G., ... Newman, W. G. (2014). Leri's pleonosteosis, a congenital rheumatic disease, results from microduplication at 8q22.1 encompassing GDF6 and SDC2 and provides insight into systemic sclerosis pathogenesis. Annals of the Rheumatic Diseases, 74(6). DOI:10.1136/annrheumdis-2013-204309. Publication link: dbf7c90f-fb4d-4e41-84ca-f95fb7b6c479 | PubMed:24442880
  • Han, B., Diogo, D., Eyre, S., Kallberg, H., Zhernakova, A., Bowes, J., ... Raychaudhuri, S. (2014). Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity. American Journal of Human Genetics, 94(4), 522-532. DOI:10.1016/j.ajhg.2014.02.013. Publication link: 950c3e9c-9f4b-44d6-a3ef-daca8c586d19 | PubMed:24656864
  • López-Isac, E., Bossini-Castillo, L., GGuerra, S., Assassi, S., Zhou, X., PilarSimeón, C., ... Martin, J. (2014). Identification of IL12RB1 as a novel systemic sclerosis susceptibility locus.Arthritis & rheumatology (Hoboken, N.J.), 66(12), 3521-3523. DOI:10.1002/art.38870. Publication link: 3035410c-f47c-420d-bbff-bf77c57e61f5 | PubMed:25199642
  • López-Isac, E., Bossini-Castillo, L., Simeon, C. P., Egurbide, M. V., Alegre-Sancho, J. J., Callejas, J. L., ... Oreiro, N. (2014). A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility. Arthritis Research and Therapy, 16(1), [R6]. DOI:10.1186/ar4432. Publication link: 440c5dcf-331d-415b-b8c9-5a2f31d5057e | PubMed:24401602
  • Mayes, M. D., Bossini-Castillo, L., Gorlova, O., Martin, J. E., Zhou, X., Chen, W. V., ... Martin, J. (2014). Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. American Journal of Human Genetics, 94(1), 47-61. DOI:10.1016/j.ajhg.2013.12.002. Publication link: 02b9e4ce-0571-41ec-b2ba-8b9c7ecf8498 | PubMed:24387989
  • Okada, Y., Diogo, D., Greenberg, J. D., Mouassess, F., Achkar, W. A. L., Fulton, R. S., ... Plenge, R. M. (2014). Integration of sequence data from a consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene. PLoS ONE, 9(2), [e87645]. DOI:10.1371/journal.pone.0087645. Publication link: e3cda1cf-5524-43f1-9074-fba02c7933ee | PubMed:24520335
  • Okada, Y., Wu, D., Trynka, G., Raj, T., Terao, C., Ikari, K., ... Plenge, R. M. (2014). Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature, 506(7488), 376-381. DOI:10.1038/nature12873. Publication link: 0a9cff07-42ec-43a7-b131-161624b9538b | PubMed:24390342
  • Orozco, G., Viatte, S., Bowes, J., Martin, P., Wilson, A. G., Morgan, A. W., ... Eyre, S. (2014). Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. Arthritis and Rheumatology, 66(1), 24-30. DOI:10.1002/art.38196. Publication link: 5965ac24-2933-4c73-982f-e5eadf9525a3 | PubMed:24114500
  • Roussos, P., Mitchell, A. C., Voloudakis, G., Fullard, J. F., Pothula, V. M., Tsang, J., ... Sklar, P. (2014). A role for noncoding variation in schizophrenia.Cell Reports, 9(4). DOI:10.1016/j.celrep.2014.10.015. Publication link: 5619eb69-52ee-4a14-b0b5-319a4df17700 | PubMed:25453756


  • Ali, F. R., Barton, A., Smith, R. L. I., Bowes, J., Flynn, E., Mangino, M., ... Warren, R. B. (2013). An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene.The British journal of dermatology, 168(4), 864-866. DOI:10.1111/bjd.12106. Publication link: c09c128d-5920-4888-bc10-3ab10135b541 | PubMed:23106574
  • Bossini-Castillo, L., Martin, J. E., Broen, J., Simeon, C. P., Beretta, L., Gorlova, O. Y., ... Martin, J. (2013). Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study. Annals of the Rheumatic Diseases, 72(4), 602-607. DOI:10.1136/annrheumdis-2012-201888. Publication link: b06500e1-60be-4745-a1f8-eea78187302c | PubMed:22896740
  • Carmona, F. D., Martin, J. E., Beretta, L., Simeón, C. P., Carreira, P. E., Callejas, J. L., ... Martín, J. (2013). The Systemic Lupus Erythematosus IRF5 Risk Haplotype Is Associated with Systemic Sclerosis. PLoS ONE, 8(1), [e54419]. DOI:10.1371/journal.pone.0054419. Publication link: 918a40f0-3f0a-46c7-8265-277a30677865 | PubMed:23372721
  • Cobb, J. E., Plant, D., Flynn, E., Tadjeddine, M., Dieudé, P., Cornélis, F., ... Worthington, J. (2013). Identification of the Tyrosine-Protein Phosphatase Non-Receptor Type 2 as a Rheumatoid Arthritis Susceptibility Locus in Europeans. PLoS ONE, 8(6), [e66456]. DOI:10.1371/journal.pone.0066456. Publication link: 5bc078c5-86f2-4cd2-a911-ff60f27dd671 | PubMed:23840476
  • David Carmona, F., Carmen Cénit, M., Diaz-Gallo, L. M., Broen, J. C. A., Simeón, C. P., Carreira, P. E., ... Martín, J. (2013). New insight on the Xq28 association with systemic sclerosis. Annals of the Rheumatic Diseases, 72(12), 2032-2038. DOI:10.1136/annrheumdis-2012-202742. Publication link: ae836277-5967-4b0d-9c46-974fc740b054 | PubMed:23444193
  • Diogo, D., Kurreeman, F., Stahl, E. A., Liao, K. P., Gupta, N., Greenberg, J. D., ... Plenge, R. M. (2013). Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis. American Journal of Human Genetics, 92(1), 15-27. DOI:10.1016/j.ajhg.2012.11.012. Publication link: b537a854-0c6d-4a01-a98f-b591462f0d15 | PubMed:23261300
  • Duffus, K., McAllister, K., Yarwood, A., Bowes, J., Orozco, G., Viatte, S., ... Eyre, S. (2013). Brief report: Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data. Arthritis and Rheumatism, 65(12), 3058-3062. DOI:10.1002/art.38183. Publication link: 83494893-5a06-44fb-841f-1f1a429f8bd9 | PubMed:24022229
  • Gusev, A., Bhatia, G., Zaitlen, N., Vilhjalmsson, B. J., Diogo, D., Stahl, E. A., ... Price, A. L. (2013). Quantifying Missing Heritability at Known GWAS Loci. PLoS Genetics, 9(12), [e1003993]. DOI:10.1371/journal.pgen.1003993. Publication link: 61bbb5f3-4f93-442c-a834-f9e03ea3a5e4 | PubMed:24385918
  • Li, G., Diogo, D., Wu, D., Spoonamore, J., Dancik, V., Franke, L., ... Plenge, R. M. (2013). Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway. PLoS Genetics, 9(5), [e1003487]. DOI:10.1371/journal.pgen.1003487. Publication link: 9457d986-b4ed-47f5-9ba0-846566866b50 | PubMed:23696745
  • Martin, J. E., Assassi, S., Diaz-Gallo, L. M., Broen, J. C., Simeon, C. P., Castellvi, I., ... Martin, J. (2013). A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. Human Molecular Genetics, 22(19), 4021-4029. DOI:10.1093/hmg/ddt248. Publication link: 26041f2f-1995-4226-96d4-b19d4e25180e | PubMed:23740937
  • Raychaudhuri, S., Diaz-Gallo, L. M., Simeon, C. P., Broen, J. C., Ortego-Centeno, N., Beretta, L., ... Beltrán, E. (2013). Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility. Annals of the Rheumatic Diseases, 72(7), 1233-1238. DOI:10.1136/annrheumdis-2012-202357. Publication link: 15267afb-dd08-4860-b8a3-b3b442e1f517 | PubMed:23172754
  • Scott, I. C., Seegobin, S. D., Steer, S., Tan, R., Forabosco, P., Hinks, A., ... Lewis, C. M. (2013). Predicting the Risk of Rheumatoid Arthritis and Its Age of Onset through Modelling Genetic Risk Variants with Smoking. PLoS Genetics, 9(9), [e1003808]. DOI:10.1371/journal.pgen.1003808. Publication link: 46243ee4-5e09-42b7-a488-531895463138 | PubMed:24068971
  • Taylor, L. H., Twigg, S., Worthington, J., Emery, P., Morgan, A. W., Wilson, A. G., & Teare, M. D. (2013). Metaanalysis of the association of smoking and PTPN22 R620W genotype on autoantibody status and radiological erosions in rheumatoid arthritis. Journal of Rheumatology, 40(7), 1048-1053. DOI:10.3899/jrheum.120784. Publication link: 1e28ab35-b72f-4c68-ba99-a2172687feb4 | PubMed:23637320
  • Viatte, S., Plant, D., Lunt, M., Fu, B., Flynn, E., Parker, B. J., ... Barton, A. (2013). Investigation of rheumatoid arthritis genetic susceptibility markers in the early rheumatoid arthritis study further replicates the TRAF1 association with radiological damage. Journal of Rheumatology, 40(2), 144-156. DOI:10.3899/jrheum.121034. Publication link: 10dce566-c9e9-44ee-9f69-81be1432e1c2 | PubMed:23242182
  • Yarwood, A., Martin, P., Bowes, J., Lunt, M., Worthington, J., Barton, A., & Eyre, S. (2013). Enrichment of vitamin D response elements in RA-associated loci supports a role for vitamin D in the pathogenesis of RA. Genes and Immunity, 14(5), 325-329. DOI:10.1038/gene.2013.23. Publication link: 6c9a5dea-6dc8-47f8-aa8f-cd977107930d | PubMed:23636220


  • Bossini-Castillo, L., Martin, J. E., Broen, J., Gorlova, O., Simeón, C. P., Beretta, L., ... Martin, J. (2012). A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Human Molecular Genetics, 21(4), 926-933. [ddr522]. DOI:10.1093/hmg/ddr522. Publication link: 24ad830e-0cfe-4d6c-9a3f-a55b67a703b5 | PubMed:22076442
  • Bossini-Castillo, L., Simeon, C. P., Beretta, L., Broen, J., Vonk, M. C., Callejas, J. L., ... Martin, J. (2012). KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor. Arthritis Research and Therapy, 14(6), [R273]. DOI:10.1186/ar4124. Publication link: 293b92a0-0468-42e0-a0cd-2d9fc43b5f51 | PubMed:23270786
  • Broen, J. C. A., Bossini-Castillo, L., Van Bon, L., Vonk, M. C., Knaapen, H., Beretta, L., ... Radstake, T. R. D. J. (2012). A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators. Arthritis and Rheumatism, 64(1), 264-271. DOI:10.1002/art.33325. Publication link: 9ea0ff43-45f2-48f5-9118-9d0360903ef6 | PubMed:21905008
  • Broen, J. C. A., Dieude, P., Vonk, M. C., Beretta, L., Carmona, F. D., Herrick, A., ... Radstake, T. R. D. J. (2012). Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression. Journal of Rheumatology, 39(1), 112-118. DOI:10.3899/jrheum.110235. Publication link: 559ad9df-4205-4ecb-b143-868878b81bd8 | PubMed:22045834
  • Cénit, M. C., Simeón, C. P., Vonk, M. C., Callejas-Rubio, J. L., Espinosa, G., Carreira, P., ... Oreiro, N. (2012). Influence of the IL6 gene in susceptibility to systemic sclerosis. Journal of Rheumatology, 39(12), 2294-2302. DOI:10.3899/jrheum.120506. Publication link: 5cb73d49-7a4b-4fc6-8edb-f21d4d89dadb | PubMed:23027890
  • Eyre, S., Bowes, J., Diogo, D., Lee, A., Barton, A., Martin, P., ... Worthington, J. (2012). High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nature Genetics, 44(12), 1336-1340. DOI:10.1038/ng.2462. Publication link: f95007e0-762f-48be-8710-a327444e68c8 | PubMed:23143596
  • Gerlag, D. M., Raza, K., Van Baarsen, L. G. M., Brouwer, E., Buckley, C. D., Burmester, G. R., ... Tak, P. P. (2012). EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: Report from the Study Group for Risk Factors for Rheumatoid Arthritis. Annals of the Rheumatic Diseases, 71(5), 638-641. DOI:10.1136/annrheumdis-2011-200990. Publication link: 89a19448-76ad-4096-9608-d9f67c65cdde | PubMed:22387728
  • Hinks, A., Cobb, J., Sudman, M., Eyre, S., Martin, P., Flynn, E., ... Wyatt, S. (2012). Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap. Annals of the Rheumatic Diseases, 71(7), 1117-1121. DOI:10.1136/annrheumdis-2011-200814. Publication link: a2797006-6e19-4298-9b00-db93e4f8b075 | PubMed:22294642
  • Kurreeman, F. A. S., Stahl, E. A., Okada, Y., Liao, K., Diogo, D., Raychaudhuri, S., ... Plenge, R. M. (2012). Use of a multiethnic approach to identify rheumatoid- arthritis- susceptibility loci, 1p36 and 17q12. American Journal of Human Genetics, 90(3), 524-532. DOI:10.1016/j.ajhg.2012.01.010. Publication link: 300d74a1-49bc-465a-ba03-e6d31b63b4e3 | PubMed:22365150
  • MacKie, S. L., Taylor, J. C., Martin, S. G., Wordsworth, P., Steer, S., Wilson, A. G., ... Morgan, A. W. (2012). A spectrum of susceptibility to rheumatoid arthritis within HLA-DRB1: Stratification by autoantibody status in a large UK population. Genes and Immunity, 13(2), 120-128. DOI:10.1038/gene.2011.60. Publication link: 38a86f1a-c561-43e2-af16-7d04db46ec8e | PubMed:21881596
  • Mackie, S. L., Taylor, J. C., Twigg, S., Martin, S. G., Steer, S., Worthington, J., ... Morgan, A. W. (2012). Relationship between area-level socio-economic,deprivationand autoantibody status in patients with rheumatoid arthritis: multicentre cross-sectional study. Annals of the Rheumatic Diseases, 71(10), 1640-1645. DOI:10.1136/annrheumdis-2011-201003. Publication link: fd515e97-6947-4022-a1c8-42d0f7ad27a7 | PubMed:22440825
  • Martin, J. E., Broen, J. C., David Carmona, F., Teruel, M., Simeon, C. P., Vonk, M. C., ... Martin, J. (2012). Identification of CSK as a systemic sclerosis genetic risk factor through genome wide association study follow-up. Human Molecular Genetics, 21(12), 2825-2835. [dds099]. DOI:10.1093/hmg/dds099. Publication link: cf56a721-3321-4527-b230-3f2620473fae | PubMed:22407130
  • Martin, J. E., Carmona, F. D., Broen, J. C. A., Simeón, C. P., Vonk, M. C., Carreira, P., ... Martín, J. (2012). The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis. Genes and Immunity, 13(2), 191-196. DOI:10.1038/gene.2011.72. Publication link: 62f7e35a-f608-4f8f-b166-991612a4a3c0 | PubMed:22012429
  • Maxwell, J. R., Marinou, I., Kuet, K. P., Orozco, G., Moore, D. J., Barton, A., ... Wilson, A. G. (2012). Rheumatoid arthritis-associated polymorphisms at 6q23 are associated with radiological damage in autoantibody-positive RA. Journal of Rheumatology, 39(9), 1781-1785. DOI:10.3899/jrheum.120144. Publication link: aac9839b-ace9-4178-8676-6c63b1fa0d69 | PubMed:22798268
  • Newman, W., Maller, J. B., McVean, G., Byrnes, J., Vukcevic, D., Palin, K., ... Donnelly, P. (2012). Bayesian refinement of association signals for 14 loci in 3 common diseases. Nature Genetics, 44(12), 1294-1301. DOI:10.1038/ng.2435. Publication link: dc5c7f30-1486-469e-a36a-ea8ffa20b886 | PubMed:23104008
  • Okada, Y., Terao, C., Ikari, K., Kochi, Y., Ohmura, K., Suzuki, A., ... Yamamoto, K. (2012). Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nature Genetics, 44(5), 511-516. DOI:10.1038/ng.2231. Publication link: 0cd58356-c410-42af-9369-e74b40b2929d | PubMed:22446963
  • Raychaudhuri, S., Sandor, C., Stahl, E. A., Freudenberg, J., Lee, H. S., Jia, X., ... De Bakker, P. I. W. (2012). Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nature Genetics, 44(3), 291-296. DOI:10.1038/ng.1076. Publication link: 9129f126-d07c-47d2-9f61-95990f8f58c4 | PubMed:22286218
  • Ronninger, M., Seddighzadeh, M., Eike, M. C., Plant, D., Daha, N. A., Skinningsrud, B., ... Padyukov, L. (2012). Interaction analysis between HLA-DRB1 shared epitope alleles and MHC class II transactivator CIITA gene with regard to risk of rheumatoid arthritis. PLoS ONE, 7(3), [e32861]. DOI:10.1371/journal.pone.0032861. Publication link: 246f8d38-b802-4030-9c8a-c4919108de88 | PubMed:22461888
  • Stahl, E. A., Wegmann, D., Trynka, G., Gutierrez-Achury, J., Do, R., Voight, B. F., ... Plenge, R. M. (2012). Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nature Genetics, 44(5), 483-489. DOI:10.1038/ng.2232. Publication link: 1285fbc9-a93f-4360-a02a-d6d71609de6b | PubMed:22446960
  • Tsoi, L. C., Spain, S. L., Knight, J., Ellinghaus, E., Stuart, P. E., Capon, F., ... Nair, R. P. (2012). Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nature Genetics, 44(12), 1341-1348. DOI:10.1038/ng.2467. Publication link: e3fba60a-7bb6-4046-b7ef-f12bc6f10f12 | PubMed:23143594
  • Viatte, S., Plant, D., Bowes, J., Lunt, M., Eyre, S., Barton, A., & Worthington, J. (2012). Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients. Annals of the Rheumatic Diseases, 71(12), 1984-1990. DOI:10.1136/annrheumdis-2011-201225. Publication link: 7097921d-1059-4bcf-b53b-700d14229400 | PubMed:22661644
  • Zaitlen, N., Lindström, S., Pasaniuc, B., Cornelis, M., Genovese, G., Pollack, S., ... Price, A. L. (2012). Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies. PLoS Genetics, 8(11), [e1003032]. DOI:10.1371/journal.pgen.1003032. Publication link: 60e190e8-5a01-4471-a320-89d97673297c | PubMed:23144628


  • Bossini-Castillo, L., Broen, J. C. A., Simeon, C. P., Beretta, L., Vonk, M. C., Ortego-Centeno, N., ... Rueda, B. (2011). A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort. Annals of the Rheumatic Diseases, 70(4), 638-641. DOI:10.1136/ard.2010.141838. Publication link: 0dee51a4-1047-47cb-bebf-1cb4747fe34d | PubMed:21187296
  • Bossini-Castillo, L., Simeon, C. P., Beretta, L., Vonk, M. C., Callejas-Rubio, J. L., Espinosa, G., ... Spanish Scleroderma Group, . U. (2011). Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population.Rheumatology, 50(11), 1976-1981. DOI:10.1093/rheumatology/ker259. Publication link: af7aaf1e-6fad-48ab-8052-20d162a41621 | PubMed:21875883
  • Bowes, J., Eyre, S., Flynn, E., Ho, P., Salah, S., Warren, R. B., ... Barton, A. (2011). Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris. Annals of the Rheumatic Diseases, 70(6), 1016-1019. DOI:10.1136/ard.2010.143123. Publication link: e3f10b93-c0ce-4b38-b5dd-fbb75b0718d6 | PubMed:21349879
  • Carmona, F. D., Simeon, C. P., Beretta, L., Carreira, P., Vonk, M. C., Ríos-Fernández, R., ... Martín, J. (2011). Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis. Annals of the Rheumatic Diseases, 70(11), 2050-2052. DOI:10.1136/ard.2010.148874. Publication link: 1cc3b3e2-f5c4-4899-9dff-9017b690d47c | PubMed:21571730
  • Chen, R., Stahl, E. A., Kurreeman, F. A. S., Gregersen, P. K., Siminovitch, K. A., Worthington, J., ... Plenge, R. M. (2011). Fine mapping the TAGAP risk locus in rheumatoid arthritis. Genes and Immunity, 12(4), 314-318. DOI:10.1038/gene.2011.8. Publication link: 74011d0b-59ac-40dc-809d-16ec66f35789 | PubMed:21390051
  • Cotsapas, C., Voight, B. F., Rossin, E., Lage, K., Neale, B. M., Wallace, C., ... Daly, M. J. (2011). Pervasive sharing of genetic effects in autoimmune disease. PLoS Genetics, 7(8), [e1002254]. DOI:10.1371/journal.pgen.1002254. Publication link: a4050a08-4b07-48cc-9620-4ff30dd77466 | PubMed:21852963
  • Diaz-Gallo, L. M., Gourh, P., Broen, J., Simeon, C., Fonollosa, V., Ortego-Centeno, N., ... Rueda, B. (2011). Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis. Annals of the Rheumatic Diseases, 70(3), 454-462. DOI:10.1136/ard.2010.130138. Publication link: 5ab2d540-ea48-4f78-97d0-a418d8475864 | PubMed:21131644
  • Eyre, S., Ke, X., Lawrence, R., Bowes, J., Panoutsopoulou, K., Barton, A., ... Zeggini, E. (2011). Examining the overlap between genome-wide rare variant association signals and linkage peaks in rheumatoid arthritis. Arthritis and Rheumatism, 63(6), 1522-1526. DOI:10.1002/art.30315. Publication link: ce6af142-bf48-44f3-8217-1f18b4d7895d | PubMed:21370227
  • Gorlova, O., Martin, J. E., Rueda, B., Koeleman, B. P. C., Ying, J., Teruel, M., ... Martin, J. (2011). Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. PLoS Genetics, 7(7), [e1002178]. DOI:10.1371/journal.pgen.1002178. Publication link: 908677f6-8663-4351-9d00-675928654201 | PubMed:21779181
  • Hinks, A., Martin, P., Flynn, E., Eyre, S., Packham, J., Barton, A., ... Thomson, W. (2011). Subtype specific genetic associations for juvenile idiopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis. Arthritis Research and Therapy, 13(1), [R12]. DOI:10.1186/ar3235. Publication link: 8816eeb1-8d84-4bf2-a6e0-6c78f78afa7e | PubMed:21281511
  • Orozco, G., Barton, A., Eyre, S., Ding, B., Worthington, J., Ke, X., & Thomson, W. (2011). HLA-DPB1-COL11A2 and three additional xMHC loci are independently associated with RA in a UK cohort. Genes and Immunity, 12(3), 169-175. DOI:10.1038/gene.2010.57. Publication link: 7d3f378f-eb74-4613-a25b-83f2977f091b | PubMed:21293383
  • Orozco, G., Eyre, S., Hinks, A., Bowes, J., Morgan, A. W., Wilson, A. G., ... Harrison, P. (2011). Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. Annals of the Rheumatic Diseases, 70(3), 463-468. DOI:10.1136/ard.2010.137174. Publication link: 53535029-239c-4aac-b66d-e26f25840bc1 | PubMed:21068098
  • Plant, D., Thomson, W., Lunt, M., Flynn, E., Martin, P., Eyre, S., ... Barton, A. (2011). The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: Results from the Norfolk Arthritis Register. Rheumatology, 50(1), 78-84. DOI:10.1093/rheumatology/keq032. Publication link: 223a449c-fdf2-4b1b-97f9-f701a7efa4e2 | PubMed:20219786
  • Warren, R. B., Smith, R. L., Flynn, E., Bowes, J., Eyre, S., Worthington, J., ... Griffiths, C. E. M. (2011). A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21. British Journal of Dermatology, 164(3), 660-664. DOI:10.1111/j.1365-2133.2011.10237.x. Publication link: 82982206-6455-40cb-a2eb-0a17743a2431 | PubMed:21375519
  • Zhernakova, A., Stahl, E. A., Trynka, G., Raychaudhuri, S., Festen, E. A., Franke, L., ... Plenge, R. M. (2011). Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genetics, 7(2), [e1002004]. DOI:10.1371/journal.pgen.1002004. Publication link: 6eef95bc-9e4f-401e-80f8-ae30596cd3a5 | PubMed:21383967


  • Alizadeh, B. Z., Broen, J., Rueda, B., Hesselstrand, R., Wuttge, D., Simeon, C., ... Radstake, T. R. D. J. (2010). Functional variants of Fc gamma receptor (FCGR2A) and FCGR3A are not associated with susceptibility to systemic sclerosis in a large European study (EUSTAR). Journal of Rheumatology, 37(8), 1673-1679. DOI:10.3899/jrheum.091259. Publication link: 2c90d4cb-ca53-41dd-b415-e021a8d39cca | PubMed:20551103
  • Bowes, J., Lawrence, R., Eyre, S., Panoutsopoulou, K., Orozco, G., Elliott, K. S., ... Zeggini, E. (2010). Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis. Human Genetics, 128(6), 627-633. DOI:10.1007/s00439-010-0889-1. Publication link: b2dd96fe-e0d5-47b3-8462-c8723228be84 | PubMed:20852893
  • Burr, M. L., Naseem, H., Hinks, A., Eyre, S., Gibbons, L. J., Bowes, J., ... Barton, A. (2010). PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian population. Annals of the Rheumatic Diseases, 69(4), 666-670. DOI:10.1136/ard.2009.111294. Publication link: 5f198ba0-babf-4b4a-8e72-675a05e87b7a
  • Craddock, N., Hurles, M. E., Cardin, N., Pearson, R. D., Plagnol, V., Robson, S., ... Donnelly, P. (2010). Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature, 464(7289), 713-720. DOI:10.1038/nature08979. Publication link: b94fb048-f1ee-42d2-b9df-f0a9854d562f | PubMed:20360734
  • Cui, J., Saevarsdottir, S., Thomson, B., Padyukov, L., Van Der Helm-van Mil, A. H. M., Nititham, J., ... Plenge, R. M. (2010). Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor α therapy. Arthritis and Rheumatism, 62(7), 1849-1861. DOI:10.1002/art.27457. Publication link: 4c52128b-a8c8-4b26-8e44-9756271ffa20 | PubMed:20309874
  • Elsby, L. M., Orozco, G., Denton, J., Worthington, J., Ray, D. W., & Donn, R. P. (2010). Functional evaluation of TNFAIP3 (A20) in rheumatoid arthritis. Clinical and Experimental Rheumatology, 28(5), 708-714. . Publication link: f2e20aae-97da-496a-934a-992f4eae3599 | PubMed:20822710
  • Hinks, A., Eyre, S., Ke, X., Barton, A., Martin, P., Flynn, E., ... Thomson, W. (2010). Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis. Annals of the Rheumatic Diseases, 69(6), 1049-1053. DOI:10.1136/ard.2009.110650. Publication link: 343386c3-1a6a-424a-9da7-a367a1994886 | PubMed:19674979
  • Hinks, A., Martin, P., Flynn, E., Eyre, S., Packham, J., Barton, A., ... Thomson, W. (2010). Association of the CCR5 gene with juvenile idiopathic arthritis. Genes and Immunity, 11(7), 584-589. DOI:10.1038/gene.2010.25. Publication link: e5201aeb-4787-489e-a5c6-ea078406fdc7 | PubMed:20463745
  • Hinks, A., Martin, P., Flynn, E., Packham, J., Barton, A., Baildam, E., ... Wyatt, S. (2010). Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis. Annals of the Rheumatic Diseases, 69(12), 2169-2172. DOI:10.1136/ard.2009.126938. Publication link: 55859f43-8d4c-4cc4-8b77-1230e034196a | PubMed:20647273
  • Kitas, G., Hassan, B., Maxwell, J. R., Hyrich, K. L., Biologics in Rheumatoid Arthritis Genetics, . U., Barton, A., ... Wilson, A. G. (2010). Genotype at the sIL-6R A358C polymorphism does not influence response to anti-TNF therapy in patients with rheumatoid arthritis.Rheumatology, 49(1), 43-47. DOI:10.1093/rheumatology/kep372. Publication link: 37ccdf13-7e91-44d4-b465-7ce03cb29135 | PubMed:19926672
  • Liu, J. Z., Tozzi, F., Waterworth, D. M., Pillai, S. G., Muglia, P., Middleton, L., ... Marchini, J. (2010). Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nature Genetics, 42(5), 436-440. DOI:10.1038/ng.572. Publication link: 770d1274-40c7-42c5-bf72-a5a3fae829c4 | PubMed:20418889
  • Morgan, A. W., Robinson, J. I., Conaghan, P. G., Martin, S. G., Hensor, E. M. A., Morgan, M. D., ... Emery, P. (2010). Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort. Arthritis Research and Therapy, 12(2), [R57]. DOI:10.1186/ar2969. Publication link: 7a6f5097-a290-4b46-830d-61111a1a5c7a | PubMed:20353580
  • Orozco, G., Eyre, S., Hinks, A., Ke, X., Wilson, A. G., Bax, D. E., ... Worthington, J. (2010). Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study. Annals of the Rheumatic Diseases, 69(5), 813-816. DOI:10.1136/ard.2009.109579. Publication link: 2ee15d97-88d2-43d6-a4cb-59dfc8648ada
  • Plant, D., Flynn, E., Mbarek, H., Dieudé, P., Cornelis, F., Ärlestig, L., ... Worthington, J. (2010). Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. Annals of the Rheumatic Diseases, 69(8), 1548-1553. DOI:10.1136/ard.2009.121020. Publication link: bc94b071-1f95-47c7-8a8d-f738904a53c1 | PubMed:20498205
  • Radstake, T. R. D. J., Gorlova, O., Rueda, B., Martin, J. E., Alizadeh, B. Z., Palomino-Morales, R., ... Mayes, M. D. (2010). Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nature Genetics, 42(5), 426-429. DOI:10.1038/ng.565. Publication link: 519357e4-9f3a-4b3b-a37f-838d31eb36d7 | PubMed:20383147
  • Stahl, E. A., Raychaudhuri, S., Remmers, E. F., Xie, G., Eyre, S., Thomson, B. P., ... Plenge, R. M. (2010). Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nature Genetics, 42(6), 508-514. DOI:10.1038/ng.582. Publication link: 07efbe49-9fb3-4b63-8f98-54a544c9594d | PubMed:20453842
  • Strange, A., Capon, F., Spencer, C. C. A., Knight, J., Weale, M. E., Allen, M. H., ... Trembath, R. C. (2010). A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1. Nature Genetics, 42(11), 985-990. DOI:10.1038/ng.694. Publication link: f245c572-d961-44eb-8cab-c4ba7d660c82 | PubMed:20953190


  • Barton, A., & Worthington, J. (2009). Genetic susceptibility to rheumatoid arthritis: An emerging picture. Arthritis Care and Research, 61(10), 1441-1446. DOI:10.1002/art.24672. Publication link: 5d1d5ce4-3f7a-4651-9d4e-84c8ecb181d1 | PubMed:19790122
  • Barton, A., Eyre, S., Ke, X., Hinks, A., Bowes, J., Flynn, E., ... Worthington, J. (2009). Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes. Human Molecular Genetics, 18(13), 2518-2522. DOI:10.1093/hmg/ddp177. Publication link: 38198ac8-e228-455b-b261-e437d62f7f23 | PubMed:19359276
  • Bowes, J. D., Potter, C., Gibbons, L. J., Hyrich, K., Plant, D., Braggss, . U., ... Barton, A. (2009). Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. Pharmacogenetics and Genomics, 19(4), 319-323. DOI:10.1097/FPC.0b013e328328d51f. Publication link: b43e74b6-366d-49c6-8f03-aaab3370f2f5
  • Hafler, J. P., Maier, L. M., Cooper, J. D., Plagnol, V., Hinks, A., Simmonds, M. J., ... Todd, J. A. (2009). CD226 Gly307Ser association with multiple autoimmune diseases. Genes and Immunity, 10(1), 5-10. DOI:10.1038/gene.2008.82. Publication link: f34c84b7-8cf7-4c11-97bd-4777d34794eb
  • Hinks, A., Barton, A., Shephard, N., Eyre, S., Bowes, J., Cargill, M., ... Thomson, W. (2009). Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis. Arthritis and Rheumatism, 60(1), 258-263. DOI:10.1002/art.24179. Publication link: 7da6970a-fbc2-423c-b598-6b3cfb7381b3
  • Hinks, A., Ke, X., Barton, A., Eyre, S., Bowes, J., Worthington, J., ... Thomson, W. (2009). Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis. Arthritis and Rheumatism, 60(1), 251-257. DOI:10.1002/art.24187. Publication link: add092ba-1892-417b-80b3-ab9ef071d207
  • McClure, A., Lunt, M., Eyre, S., Ke, X., Thomson, W., Hinks, A., ... Consortium, B. I. R. A. C. (2009). Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci.Rheumatology, 48(11), 1369-1374. DOI:10.1093/rheumatology/kep272. Publication link: faa78c27-a4d9-4a1b-adfd-6722849bbe68 | PubMed:19741008
  • Morgan, A. W., Thomson, W., Martin, S. G., Carter, A. M., Erlich, H. A., Barton, A., ... Martin, P. (2009). Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK caucasian population. Arthritis and Rheumatism, 60(9), 2565-2576. DOI:10.1002/art.24752. Publication link: 8c2dad89-59ae-45bc-ac55-f9096aad187d | PubMed:19714585
  • Plant, D., Barton, A., Thomson, W., Ke, X., Eyre, S., Hinks, A., ... Worthington, J. (2009). A re-evaluation of three putative functional single nucleotide polymorphisms in rheumatoid arthritis. Annals of the Rheumatic Diseases, 68(8), 1373-1375. DOI:10.1136/ard.2008.103572. Publication link: df053985-40bf-4f0b-b7ac-f4b813b857e1
  • Potter, C., Hyrich, K. L., Tracey, A., Lunt, M., Plant, D., Symmons, D. P. M., ... Barton, A. (2009). Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis. Annals of the Rheumatic Diseases, 68(1), 69-74. DOI:10.1136/ard.2007.084715. Publication link: 6cca44ae-a359-469c-8374-91980053c048
  • Quaranta, M., Burden, A. D., Griffiths, C. E. M., Worthington, J., Barker, J. N., Trembath, R. C., & Capon, F. (2009). Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes. Genes and Immunity, 10(7), 654-658. DOI:10.1038/gene.2009.51. Publication link: 6d43d6ba-e633-4f65-8302-9a1fca103d57 | PubMed:19587699
  • Raychaudhuri, S., Thomson, B. P., Remmers, E. F., Eyre, S., Hinks, A., Guiducci, C., ... Plenge, R. M. (2009). Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nature Genetics, 41(12), 1313-1318. DOI:10.1038/ng.479. Publication link: 2d3448b2-73c0-4a73-b9a0-5e6890df32bc | PubMed:19898481
  • Rueda, B., Simeon, C., Hesselstrand, R., Herrick, A., Worthington, J., Ortego-Centeno, N., ... Martin, J. (2009). A large multicentre analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype. Annals of the Rheumatic Diseases, 68(10), 1618-1620. DOI:10.1136/ard.2008.100180. Publication link: 8f61c5a4-9ab9-47b5-83cd-d2da59da39aa
  • Smith, R. L., Warren, R. B., Griffiths, C. E. M., & Worthington, J. (2009). Genetic susceptibility to psoriasis: An emerging picture. Genome Medicine, 1(7), [gm72]. DOI:10.1186/gm72. Publication link: 88aa470c-edf7-4395-92b6-cfe12ebf7f88 | PubMed:19638187
  • Van Der Woude, D., Houwing-Duistermaat, J. J., Toes, R. E. M., Huizinga, T. W. J., Thomson, W., Worthington, J., ... De Vries, R. R. P. (2009). Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis. Arthritis and Rheumatism, 60(4), 916-923. DOI:10.1002/art.24385. Publication link: d0e7cd46-2897-4566-b6ce-2e7bdab3f377
  • Warren, R. B., Smith, R. L., Campalani, E., Eyre, S., Smith, C. H., Barker, J. N. W. N., ... Griffiths, C. E. M. (2009). Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms. British Journal of Dermatology, 160(2), 438-441. DOI:10.1111/j.1365-2133.2008.08898.x. Publication link: 94e1ce12-2b7f-40c4-92fa-bc35de51f77e | PubMed:19016697


  • Barton, A., Bruce, I. N., Worthington, J., Liu, Y., Helms, C., Liao, W., ... Bowcock, A. (2008). A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease Loci.PLoS Genet, 4 (3). DOI:10.1371/journal.pgen.1000041. Publication link: 06486fc1-0f85-4c5d-8c47-76fa02e7b3fb
  • Barton, A., Thomson, W., Ke, X., Eyre, S., Hinks, A., Bowes, J., ... Worthington, J. (2008). Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics, 40(10), 1156-1159. DOI:10.1038/ng.218. Publication link: fb79be2b-9338-4230-b01b-99ce8c3a750f
  • Capon, F., Bijlmakers, M. J., Wolf, N., Quaranta, M., Huffmeier, U., Allen, M., ... Trembath, R. C. (2008). Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. Human Molecular Genetics, 17(13), 1938-1945. DOI:10.1093/hmg/ddn091. Publication link: 2bd1cdba-d633-4a0d-8a8b-19f3461eb621 | PubMed:18364390
  • Ho, P. Y. P. C., Barton, A., Worthington, J., Plant, D., Griffiths, C. E. M., Young, H. S., ... Bruce, I. N. (2008). Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: Comparison with psoriasis and undifferentiated inflammatory arthritis. Annals of the Rheumatic Diseases, 67(5), 677-682. DOI:10.1136/ard.2007.071399. Publication link: b0785510-9c5f-4e3f-82fa-791a0dc940cd
  • Maxwel, J. R., Potter, C., Hyrich, K. L., Barton, A., Worthington, J., Isaacs, J. D., ... Wilson, A. G. (2008). Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis. Human Molecular Genetics, 17(22), 3532-3538. DOI:10.1093/hmg/ddn245. Publication link: d32686b5-c870-414b-91c9-9438a37340be
  • Morgan, A. W., Haroon-Rashid, L., Martin, S. G., Gooi, H. C., Worthington, J., Thomson, W., ... Emery, P. (2008). The shared epitope hypothesis in rheumatoid arthritis: Evaluation of alternative classification criteria in a large UK Caucasian cohort. Arthritis and Rheumatism, 58(5), 1275-1283. DOI:10.1002/art.23432. Publication link: 4573af0f-6365-4a51-a119-b4292a030a65
  • Naseem, H., Thomson, W., Silman, A., Worthington, J., Symmons, D., & Barton, A. (2008). The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome. Annals of the Rheumatic Diseases, 67(2), 251-255. DOI:10.1136/ard.2007.071894. Publication link: 2527abc4-712e-423b-9287-ddac5bf01834
  • Payton, A., Worthington, J., Ollier, W. E. R., Ashworth, J. J., Smyth, J. V., Pendleton, N., ... Ashcroft, G. G. (2008). Polymorphisms spanning the 0N exon and promoter of the estrogen receptor-beta (ERbeta) gene ESR2 are associated with venous ulceration.Clin Genet, 73 (1). . Publication link: 58a057fc-3cc4-41ad-84ce-448b96d096c0
  • Pushpakom, S. P., Herrick, A. L., Kumar, S., & Worthington, J. (2008). Polymorphisms in COL15 gene are not associated with systemic sclerosis. Journal of Rheumatology, 35(2), 251-253. . Publication link: 0f55b36e-b9e1-4def-a0cc-3cda6f078aa7
  • Raychaudhuri, S., Remmers, E. F., Lee, A. T., Hackett, R., Guiducci, C., Burtt, N. P., ... Plenge, R. M. (2008). Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nature Genetics, 40(10), 1216-1223. DOI:10.1038/ng.233. Publication link: afb879d7-7e26-4317-bd69-1aeb0c598cd7
  • Warren, R., Smith, R. L., Eyre, S., Warren, R. B., Young, H. S., Griffiths, C. E. M., & Worthington, J. (2008). No association between polymorphisms in the interleukin-15 gene and early-onset psoriasis in a UK cohort suggests heterogeneity for this susceptibility locus identified in Chinese psoriasis patients. Journal of Investigative Dermatology, 128(12), 2904-2905. DOI:10.1038/jid.2008.148. Publication link: 1665e690-a4e8-4191-abf2-ea99d2ee7444
  • Warren, R., Smith, R. L., Warren, R. B., Eyre, S., Ho, P., Ke, X., ... Worthington, J. (2008). Polymorphisms in the IL-12β and IL-23R genes are associated with psoriasis of early onset in a UK cohort. Journal of Investigative Dermatology, 128(5), 1325-1327. DOI:10.1038/sj.jid.5701140. Publication link: 1c3964a8-ce70-4dd1-aebe-4b4081bb1718
  • Warren, R., Smith, R. L., Warren, R. B., Eyre, S., Ke, X., Young, H. S., ... Worthington, J. (2008). Polymorphisms in the PTPN22 region are associated with psoriasis of early onset. British Journal of Dermatology, 158(5), 962-968. DOI:10.1111/j.1365-2133.2008.08482.x. Publication link: 8a1aff29-4ab1-45a6-b412-80cb175c9d43 | PubMed:18341666
  • Warren, R., Warren, R. B., Smith, R. L., Campalani, E., Eyre, S., Smith, C. H., ... Griffiths, C. E. M. (2008). Genetic variation in efflux transporters influences outcome to methotrexate therapy in patients with psoriasis. Journal of Investigative Dermatology, 128(8), 1925-1929. DOI:10.1038/jid.2008.16. Publication link: 2f165848-24ef-40a0-8351-7b95af6ec56c | PubMed:18256692
  • Wolf, N., Quaranta, M., Prescott, N. J., Allen, M., Smith, R., Burden, A. D., ... Trembath, R. C. (2008). Psoriasis is associated with pleiotropic susceptibility loci identified in type II diabetes and Crohn disease. Journal of Medical Genetics, 45(2), 114-116. DOI:10.1136/jmg.2007.053595. Publication link: cd0bafd2-80ca-4cd1-a2e1-6db2515c18ba
  • Ollier, W. E. R., Worthington, J., Hochberg, M. C., Smolen, J. S., Weinblatt, M. E., & Weisman, M. H. (2008). Investigation of the genetic basis of rheumatic diseases. In Rheumatology. (Vol. 13). London: Elsevier. . Publication link: b04a7a3f-91bc-493d-9a6a-59c580cd4d97
  • Ho, P. Y. P. C., Barton, A., Worthington, J., Plant, D., Griffiths, C. E. M., Young, H. S., ... Bruce, I. N. (2008). Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: Comparison with psoriasis and undifferentiated inflammatory arthritis. (Ann Rheum Dis; Vol. 67( 5)). England: Academic Press. DOI:10.1136/ard.2007.071399. Publication link: 13250992-ca9b-4082-b4fd-37e58b7565c6
  • Smith, R., Warren, R. B., Eyre, S. S., Ho, P. Y., Ke, X., Young, H., ... Worthington, J. (2008). Polymorphisms in the IL-12beta and IL-23R genes are associated with psoriasis of early onset in a UK cohort.J Invest Dermatol, 128( 5). . Publication link: bd030c78-dd7f-4115-9850-fc78e550dc46


  • Amos, C. I., Chen, W. V., Remmers, E., Siminovitch, K. A., Seldin, M. F., Criswell, L. A., ... Gregersen, P. K. (2007). Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits.BMC proceedings, 1 Suppl 1(Suppl 1). DOI:10.1186/1753-6561-1-s1-s3. Publication link: b1753d36-8328-4eb4-9a01-37e954d37fb1 | PubMed:18466527
  • Barrett, J. H., Sheehan, N. A., Cox, A., Worthington, J., Cannings, C., & Teare, M. D. (2007). Family based studies and genetic epidemiology: Theory and practice. Human Heredity, 64(2), 146-148. DOI:10.1159/000101993. Publication link: afc168b5-aa5a-4037-8f5d-7b30c524c2c6 | PubMed:17476114
  • Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Duncanson, A., Kwiatkowski, D. P., ... Hider, S. (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics, 39(11), 1329-1337. DOI:10.1038/ng.2007.17. Publication link: 68149a9e-dc3e-440b-b7ad-605a11625e24
  • Donn, R., Berry, A., Stevens, A., Farrow, S., Betts, J., Stevens, R., ... Ray, D. (2007). Use of gene expression profiling to identify a novel glucocorticoid sensitivity determining gene, BMPRII. FASEB Journal, 21(2), 402-414. DOI:10.1096/fj.06-7236com. Publication link: 5cd9cc3f-0fb9-4647-a2b7-2fca6fc18cb2 | PubMed:17185747
  • Donovan, H., Gilbert, P., Hider, S., John, S., Silman, A., Barton, A., ... Tobin, M. D. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447(7145), 661-678. DOI:10.1038/nature05911. Publication link: 452b3da6-d34c-4f12-961f-eacc47405871
  • Feitsma, A. L., Worthington, J., Van Der Helm-van Mil, A. H. M., Plant, D., Thomson, W., Ursum, J., ... De Vries, R. R. P. (2007). Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development. Proceedings of the National Academy of Sciences of the United States of America, 104(50), 19966-19970. DOI:10.1073/pnas.0710260104. Publication link: aa2bac54-7c1b-4e60-81a4-eb2b3e417b39
  • Hinks, A. M., Eyre, S. S., Barton, A., Thomson, W., & Worthington, J. (2007). Investigation of genetic variation across PTPN22 in UK rheumatoid arthritis (RA) patients.Ann Rheum Dis, 66(5). . Publication link: f18e7bd6-3bd0-4560-a0b0-0d68c41b74bb
  • Potter, C., Eyre, S., Cope, A., Worthington, J., & Barton, A. (2007). Investigation of association between the TRAF family genes and RA susceptibility. Annals of the Rheumatic Diseases, 66(10), 1322-1326. DOI:10.1136/ard.2006.065706. Publication link: 0b9883d4-713e-4fb2-bf67-0ad984bc1ffc


  • Eyre, S., Bowes, J., Potter, C., Worthington, J., & Barton, A. (2006). Association of the FCRL3 gene with rheumatoid arthritis: A further example of population specificity?. Arthritis Research and Therapy, 8(4), [R117]. DOI:10.1186/ar2006. Publication link: 2897cb0d-880e-4156-911f-0f04216c9e1e
  • Hinks, A., Worthington, J., & Thomson, W. (2006). The association of PTPN22 with rheumatoid arthritis and juvenile idiopathic arthritis. Rheumatology, 45(4), 365-368. . Publication link: f9318bca-fe38-4ab7-882c-5a2b7804b51d
  • Payton, A., van den Boogerd, E., Davidson, Y., Gibbons, L., Ollier, W., Rabbitt, P., ... Pendleton, N. (2006). Influence and interactions of cathepsin D, HLA-DRB1 and APOE on cognitive abilities in an older non-demented population.Genes, Brain and Behavior, 5, 23-31. DOI:10.1111/j.1601-183X.2006.00191.x. Publication link: 2e16df6c-92bf-486d-a5d2-5e02a705f5aa
  • Plant, D., Young, H. S., Watson, R. E. B., Worthington, J., & Griffiths, C. E. M. (2006). The CX3CL1-CX3CR1 system and psoriasis. Experimental Dermatology, 15(11), 900-903. DOI:10.1111/j.1600-0625.2006.00486.x. Publication link: ba241147-208d-4bf3-a9d9-8aee4afbd9f6


  • Ashworth, J. J., Smyth, J. V., Pendleton, N., Horan, M., Payton, A., Worthington, J., ... Ashcroft, G. S. (2005). The dinucleotide (CA) repeat polymorphism of estrogen receptor beta but not the dinucleotide (TA) repeat polymorphism of estrogen receptor alpha is associated with venous ulceration. Journal of Steroid Biochemistry and Molecular Biology, 97(3), 266-270. DOI:10.1016/j.jsbmb.2005.05.012. Publication link: 3f495d77-10f5-4c48-86f5-961b02a719ca | PubMed:16153823
  • Barton, A., Eyre, S., Bowes, J., Ho, P., John, S., & Worthington, J. (2005). Investigation of the SLC22A4 gene (associated with rheumatoid arthritis in a Japanese population) in a United Kingdom population of rheumatoid arthritis patients. Arthritis and Rheumatism, 52(3), 752-758. DOI:10.1002/art.20877. Publication link: 349c6ffd-d934-4362-aae5-9a5a8bfddfe4
  • Hinks, A., Barton, A., John, S., Bruce, I., Hawkins, C., Griffiths, C. E. M., ... Worthington, J. (2005). Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: Further support that PTPN22 is an autoimmunity gene. Arthritis and Rheumatism, 52(6), 1694-1699. DOI:10.1002/art.21049. Publication link: e8b09096-1166-4032-9ba5-95a207fa1bff
  • Ho, P., Bruce, I. N., Silman, A., Symmons, D., Newman, B., Young, H., ... Barton, A. (2005). Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis. Arthritis and Rheumatism, 52(11), 3596-3602. DOI:10.1002/art.21393. Publication link: af385c21-9987-4acd-a736-3ee4adf15f1b
  • Ollier, W. E. R., Worthington, J., Karasneh, J., Gul, A., & Silman, A. J. (2005). Whole-genome screening for susceptibility genes in multicase families with Behcet's disease.Arthritis Rheum, 52( 6). . Publication link: c0d63577-1948-4323-abce-ff38ed2753b6
  • Payton, A., Gibbons, L., Davidson, Y., Ollier, W., Rabbitt, P., Worthington, J., ... Horan, M. (2005). Influence of serotonin transporter gene polymorphisms on cognitive decline and cognitive abilities in a nondemented elderly population. Molecular Psychiatry, 10(12), 1133-1139. DOI:10.1038/ Publication link: f9f28b31-f838-4988-ab58-e73ee9fc3304
  • Payton, A., Worthington, J., Ollier, W. E. R., Ashworth, J. J., Vincent, S. J., Pendleton, N., ... Ashcroft, G. G. (2005). The dinucleotide (CA)repeat polymorphism of estrogen receptor beta but not the dinulclotide (TA)repeat polymorphism of estrogen receptor alpha is associated with venous ulceration. J Steroid Biochem Mol Biol, 97(3). . Publication link: 79c88497-d517-4567-85d6-75185dce1b80
  • Stevenson, J., Langley, K., Pay, H., Payton, A., Worthington, J., Ollier, W., & Thapar, A. (2005). Attention deficit hyperactivity disorder with reading disabilities: Preliminary genetic findings on the involvement of the ADRA2A gene. Journal of Child Psychology and Psychiatry and Allied Disciplines, 46(10), 1081-1088. DOI:10.1111/j.1469-7610.2005.01533.x. Publication link: 518396e2-8ee2-4d50-b1fc-de497013830a
  • Worthington, J., Ollier, W. E. R., Karasneh, J., Hajeer, A., Silman, A. J., & Gul, A. (2005). Polymorphisms in the endothelial nitric oxide synthase gene are associated with Behcet's disease.Rheumatology (Oxford), 44( 5). . Publication link: 93719231-c7bb-46bd-8d9d-d28d531097c8
  • Zeggini, E., Barton, A., Eyre, S., Ward, D., Ollier, W., Worthington, J., & John, S. (2005). Characterisation of the genomic architecture of human chromosome 17q and evaluation of different methods for haplotype block definition.BMC genetics, 6, [21]. . Publication link: 98c65869-c428-4639-838a-04a5735f8814
  • Worthington, J., Ollier, W., Payton, A., & Gibson, M. (2005). Single-nucleotide polymorphisms (SNPs) in the IGFBP1 gene are associated with diabetes risk and nephropathy in a cohort of type 2 diabetes mellitus patients.In Diabetes. (Vol. 54). Publication link: ccb9ea66-f01f-4d9e-8703-6a9e3222ad7f


  • Barton, A., Platt, H., Salway, F., Symmons, D., Lunt, M., Worthington, J., & Silman, A. (2004). Polymorphisms in the Mannose Binding Lectin (MBL) Gene Are Not Associated with Radiographic Erosions in Rheumatoid or Inflammatory Polyarthritis. Journal of Rheumatology, 31(3), 442-447. . Publication link: 6901b234-850d-4856-b861-d558d8fc27a8
  • Barton, A., Woolmore, J. A., Ward, D., Eyre, S., Hinks, A., Ollier, W. E. R., ... Worthington, J. (2004). Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population. Brain, 127(8), 1717-1722. DOI:10.1093/brain/awh193. Publication link: 6a563594-ddcd-435f-954b-087afb151e30
  • Donn, R. P., Plant, D., Jury, F., Richards, H. L., Worthington, J., Ray, D. W., & Griffiths, C. E. M. (2004). Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis. Journal of Investigative Dermatology, 123(3), 484-487. DOI:10.1111/j.0022-202X.2004.23314.x. Publication link: 8d9c9292-752a-4120-8621-52de67b85fb0
  • John, S., Shephard, N., Liu, G., Zeggini, E., Cao, M., Chen, W., ... Kennedy, G. C. (2004). Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: Comparison with microsatellites. American Journal of Human Genetics, 75(1), 54-64. DOI:10.1086/422195. Publication link: ce34c8b1-fddb-44fe-8a1f-a577ca695d58
  • Kilding, R., Iles, M. M., Timms, J. M., Worthington, J., & Wilson, A. G. (2004). Additional Genetic Susceptibility for Rheumatoid Arthritis Telomeric of the DRB1 Locus. Arthritis and Rheumatism, 50(3), 763-769. DOI:10.1002/art.20043. Publication link: caf89060-7bea-4160-8ca3-ae209a4b4c50
  • Marriage, F., Barton, A., Platt, H., Salway, F., Symmons, D., Barrett, E., ... Silman, A. (2004). Polymorphisms in the tumour necrosis factor gene are not associated with severity of inflammatory polyarthritis. Annals of the Rheumatic Diseases, 63(3), 280-284. DOI:10.1136/ard.2003.008680. Publication link: ba78aa54-4272-434a-923f-ec8fbab114be
  • Plant, D., Worthington, J., Griffiths, C. E. M., Lear, J. T., & Marsland, A. (2004). CARD15/NOD2 single nucleotide polymorphisms do not confer susceptibility to type 1 psoriasis. British Journal of Dermatology, 151, 3. . Publication link: f4c40ab0-99f8-457b-b844-8a6e5a0fb578


  • John, S., SmithS, . U., MorrisonJF, . U., Symmons, D., Worthington, J., Silman, A. J., & Barton, A. (2003). Genetic variation in the cytokine chemokine receptor 5 (CCR5) does not predict clinical outcome in inflammatory polyarthritis. Arthritis and Rheumatism, 48(12). . Publication link: b0544dc4-86c4-415d-bbf7-7261c72f9713
  • Langley, K., Payton, A., Hamshere, M. L., Pay, H. M., Lawson, D. C., Turic, D., ... Thapar, A. (2003). No evidence of association of two 5HT transporter gene polymorphisms and attention deficit hyperactivity disorder. Psychiatric Genetics, 13(2), 107-110. DOI:10.1097/00041444-200306000-00009. Publication link: e4f9f9de-dc35-4fd3-9fba-1259043690ed
  • Morgan, A. W., Keyte, V. H., Babbage, S. J., Robinson, J. I., Ponchel, F., Barrett, J. H., ... Isaacs, J. D. (2003). FcγRIIIA-158V and rheumatoid arthritis: A confirmation study. Rheumatology, 42(4), 528-533. DOI:10.1093/rheumatology/keg169. Publication link: fc79bd45-6315-44b8-a379-25099112ee8b
  • Payton, A., Holland, F., Diggle, P., Rabbitt, P., Horan, M., Davidson, Y., ... Pendleton, N. (2003). Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population. Molecular Psychiatry, 8(1), 14-18. DOI:10.1038/ Publication link: 855c2ff6-c017-4f8d-be8f-55fa0603fe7c | PubMed:12556904
  • Payton, A., Turic, D., Langley, K., Mills, S., Lawson, D. C., Van Den Bree, M., ... Thapar, A. (2003). No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder. Psychiatric Genetics, 13(3), 183-185. DOI:10.1097/00041444-200309000-00009. Publication link: 1d389fab-1d81-4af4-89e3-2a901d535355
  • Shephard, N., Falcaro, M., Zeggini, E., Chapman, P., Hinks, A., Barton, A., ... John, S. (2003). Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure.BMC genetics, 4, [S26]. . Publication link: e4f91094-8b35-48c4-b43a-65785b30e8b9
  • Strickland, P. L., John, S., Payton, A., Worthington, J., Ollier, W. E. R., & Deakin, J. F. W. (2003). Do genetic polymorphisms of serotonin (5-HT) neurotransmission influence function in humans? [3]. American Journal of Medical Genetics, 120(4), 566-567. . Publication link: d2f504cd-579e-4a3b-9ced-542e3223c9c4
  • Worthington, J., & John, S. (2003). Association of PADI4 and rheumatoid arthritis: A successful multidisciplinary approach. Trends in Molecular Medicine, 9(10), 405-407. DOI:10.1016/j.molmed.2003.08.007. Publication link: 183e5bb3-816c-4a49-bc95-fd5a7dddd0e5
  • Hinks, A. M., Barton, A., Worthington, J., Pickles, A., Shepherd, N., Falcaro, M., ... John, S. (2003). Linkage and association analysis of alternative phenotypic measures to identify loci influencing blood pressure. In Proceedings of the XIII Genetic Analysis Workshop.. Publication link: a9e7573a-59eb-42ad-9443-6b26e917b62b


  • Barton, A. C., & Worthington, J. (2002). Commentary on "genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus", by RR Graham et al. Arthritis Research, 4(2), 84-86. DOI:10.1186/ar394. Publication link: 49caa2de-9044-4586-8719-e385c210555f
  • Fife, M., Steer, S., Fisher, S., Newton, J., McKay, K., Worthington, J., ... Lanchbury, J. (2002). Association of familial and sporadic rheumatoid arthritis with a single corticotropin-releasing hormone genomic region (8q12.3) haplotype. Arthritis and Rheumatism, 46(1), 75-82. DOI:10.1002/1529-0131(200201)46:1<75::AID-ART10034>3.0.CO;2-3. Publication link: 78f8be7f-3a8f-4092-8c13-26c2a906916f
  • Herrick, A. L., & Worthington, J. (2002). Genetic epidemiology systemic sclerosis. Arthritis Research, 4(3), 165-168. DOI:10.1186/ar402. Publication link: 944ccf0d-3e94-4d44-b620-bb921221cfb5
  • Holmes, J., Payton, A., Barrett, J., Harrington, R., McGuffin, P., Owen, M., ... Thapar, A. (2002). Association of DRD4 in children with ADHD and comorbid conduct problems. American Journal of Medical Genetics - Neuropsychiatric Genetics, 114(2), 150-153. DOI:10.1002/ajmg.10149. Publication link: d8ad7c00-43fb-43f5-b88e-ded360446022
  • Pendleton, N., Payton, A., Van den Boogerd, E. H., Holland, F., Diggle, P., Rabbitt, P. M. A., ... Ollier, W. E. R. (2002). Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults. Neuroscience Letters, 324(1), 74-76. DOI:10.1016/S0304-3940(02)00135-0. Publication link: aa92432a-fb4a-47c5-9e06-b02821c9172f | PubMed:11983298


  • Barton, A., Eyre, S., Myerscough, A., Brintnell, B., Ward, D., Ollier, W. E. R., ... Worthington, J. (2001). High resolution linkage and association mapping identifies a novel rheumatoid arthritis susceptibility locus homologous to one linked to two rat models of inflammatory arthritis. Human Molecular Genetics, 10(18), 1901-1906. DOI:10.1093/hmg/10.18.1901. Publication link: aeb82572-d269-45f7-a9ce-4e6a3b4c3f83
  • Gül, A., Hajeer, A. H., Worthington, J., Ollier, W. E. R., & Silman, A. J. (2001). Linkage mapping of a novel susceptibility locus for behçet's disease to chromosome 6p22-23. Arthritis and Rheumatism, 44(11), 2693-2696. DOI:10.1002/1529-0131(200111)44:11<2693::AID-ART449>3.0.CO;2-M. Publication link: 9eee9c03-2338-4002-8205-d25f206cad3b
  • Hinks, A., Barton, A., Chapman, P., Myerscough, A., Pinel, T., Davies, N., ... John, S. (2001). The single-nucleotide polymorphism lottery: How useful are a few common SNPs in identifying disease-associated alleles?. Genetic Epidemiology, 21(1), S384-S389. . Publication link: 111b60fb-cbec-489c-be76-b69a1938f5d1
  • John, S., Eyre, S., Myerscough, A., Barrett, J., Silman, A., Ollier, W., & Worthington, J. (2001). Linkage and association analysis of candidate genes in rheumatoid arthritis. Journal of Rheumatology, 28(8), 1752-1755. . Publication link: dc71576e-a2ff-4c48-beb9-1e8712192092
  • Payton, A., Holmes, J., Barrett, J. H., Hever, T., Fitzpatrick, H., Trumper, A. L., ... Thapar, A. (2001). Examining for association between candidate gene polymorphisms in the dopamine pathway and attention-deficit hyperactivity disorder: A family-based study. American Journal of Medical Genetics - Neuropsychiatric Genetics, 105(5), 464-470. DOI:10.1002/ajmg.1407. Publication link: 18f95ca4-b534-4ca2-b709-202c20c4904e
  • Payton, A., Holmes, J., Barrett, J. H., Sham, P., Harrington, R., McGuffin, P., ... Thapar, A. (2001). Susceptibility genes for a trait measure of attention deficit hyperactivity disorder: A pilot study in a non-clinical sample of twins. Psychiatry Research, 105(3), 273-278. DOI:10.1016/S0165-1781(01)00342-0. Publication link: 4e101537-daa5-4d31-849b-8ded35aeed67
  • Stevens, A., Ray, D. W., Worthington, J., & Davis, J. R. E. (2001). Polymorphisms of the human prolactin gene - Implications for production of lymphocyte prolactin and systemic lupus erythematosus. Lupus, 10(10), 676-683. DOI:10.1191/096120301717164903. Publication link: a263d59e-c2fc-4770-9aae-f1f8fcd1c173
  • Stevens, A., Ray, D., Alansari, A., Hajeer, A., Thomson, W., Donn, R., ... Davis, J. R. E. (2001). Characterization of a prolactin gene polymorphism and its associations with systemic lupus erythematosus. Arthritis and Rheumatism, 44(10), 2358-2366. DOI:10.1002/1529-0131(200110)44:10<2358::AID-ART399>3.0.CO;2-K. Publication link: b5e433b6-636c-4b7c-8689-d0db15fb6a57
  • Weatherby, S. J. M., Thomson, W., Pepper, L., Donn, R., Worthington, J., Mann, C. L. A., ... Hawkins, C. P. (2001). HLA-DRB1 and disease outcome in multiple sclerosis. Journal of Neurology, 248(4), 304-310. DOI:10.1007/s004150170205. Publication link: 20b97818-7277-479c-8d96-12e43fcd265d
  • Worthington, J., & John, S. (2001). Genetic epidemiology. Approaches to the genetic analysis of rheumatoid arthritis. Arthritis Res, 3, 4. . Publication link: 95f029dd-3d0d-494b-9f5f-de6ef4925104


  • Barton, A., Myerscough, A., John, S., Gonzalez-Gay, M., Oilier, W., & Worthington, J. (2000). A single nucleotide polymorphism in exon 1 of cytotoxic T-lymphocyte-associated-4 (CTLA-4) is not associated with rheumatoid arthritis. Rheumatology, 39(1), 63-66. . Publication link: c9339b51-807a-4b02-95af-a494edc8b90c
  • Fife, M. S., Fisher, S. A., John, S., Worthington, J., Shah, C. J., Ollier, W. E. R., ... Lanchbury, J. S. (2000). Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region. Arthritis and Rheumatism, 43(8), 1673-1678. DOI:10.1002/1529-0131(200008)43:8<1673::AID-ANR2>3.0.CO;2-Y. Publication link: 60880485-fdc2-4d44-84a5-467cf7e1fc98
  • Hajeer, A. H., Lear, J. T., Ollier, W. E. R., Naves, M., Worthington, J., Bell, D. A., ... Fryer, A. A. (2000). Preliminary evidence of an association of tumour necrosis factor microsatellites with increased risk of multiple basal cell carcinomas. British Journal of Dermatology, 142(3), 441-445. DOI:10.1046/j.1365-2133.2000.03353.x. Publication link: 8ce18546-e9ad-4fbc-affb-52a855e35eb8
  • Holmes, J., Payton, A., Barrett, J. H., Hever, T., Fitzpatrick, H., Trumper, A. L., ... Thapar, A. (2000). A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficit hyperactivity disorder. Molecular Psychiatry, 5(5), 523-530. . Publication link: 20560eb6-6265-431a-b81c-60c22e0744fb
  • Ollier, W. E. R., Worthington, J., SusolE, . U., MacGregorAJ, . U., BarrettJH, . U., WilsonH, . U., ... Silman, A. J. (2000). A two-stage, genome-wide screen for susceptibility loci in primary Raynaud's phenomenon. Arthritis and Rheumatism, 43, 7. . Publication link: c9ec4175-2bb7-4764-9a4d-7b162b044345
  • Ollier, W. E. R., Worthington, J., SusolE, . U., RandsAL, . U., HerrickA, . U., McHughN, . U., & BarrettJH, . U. (2000). Association of markers for TGFbeta3, TGFbeta2 and TIMP1 with systemic sclerosis. Rheumatology, 39, 12. . Publication link: b48344b9-42b0-4372-84f0-81dd8477e5d5


  • Donn, R. P., Farhan, A. J., Barrett, J. H., Thomson, W., Worthington, J., & Ollier, W. E. R. (1999). Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients. Rheumatology, 38(2), 171-175. DOI:10.1093/rheumatology/38.2.171. Publication link: 198588a3-56e4-4668-ad21-0befdb250b52 | PubMed:10342632
  • Worthington, J., Ollier, W. E. R., Cox, A., Camp, N. J., Cannings, C., Di Giovine, F. S., ... Duff, G. W. (1999). The Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis.Human Molecular Genetics, 8, 9. . Publication link: 1ca77b56-b58b-4267-82f3-77a533468304


  • John, S., Korman, Y., Ollier, W., & Worthington, J. (1998). Integrated microsatellite markers suitable for genetic studies of cytokine genes. Cytokine, 10(6), 466-470. DOI:10.1006/cyto.1997.0317. Publication link: 1cf1cf23-e941-46e5-be87-68c8ddc6c4bb
  • John, S., Myerscough, A., Marlow, A., Hajeer, A., Silman, A., Ollier, W., & Worthington, J. (1998). Linkage of cytokine genes to rheumatoid arthritis. Evidence of genetic heterogeneity. Annals of the Rheumatic Diseases, 57(6), 361-365. . Publication link: 99010716-c708-4040-840b-8f10db1f75a3
  • John, S., Turner, D., Donn, R., Sinnott, P., Worthington, J., Ollier, W. E. R., ... Hajeer, A. H. (1998). Two novel biallelic polymorphisms in the IL-2 gene. European Journal of Immunogenetics, 25(6), 419-420. DOI:10.1046/j.1365-2370.1998.00139.x. Publication link: bd8c865a-d831-49cf-9705-51aabb9683f2 | PubMed:9949947
  • Naves, M., Hajeer, A. H., Teh, L. S., Davies, E. J., Ordi-Ros, J., Perez-Pemen, P., ... Ollier, W. E. R. (1998). Complement C4B null allele status confers risk for systemic lupus erythematosus in a Spanish population. European Journal of Immunogenetics, 25(4), 317-320. DOI:10.1046/j.1365-2370.1998.00110.x. Publication link: f66776d0-22da-415e-88e4-a207529b5cca


  • Hajeer, A. H., Worthington, J., Davies, E. J., Hillarby, M. C., Poulton, K., & Ollier, W. E. R. (1997). TNF microsatellite a2, b3 and d2 alleles are associated with systemic lupus erythematosus. Tissue Antigens, 49(3 I), 222-227. . Publication link: d3d0db9e-4ba7-445f-b08a-8e3cdfe3cc3d
  • Hajeer, A., John, S., Ollier, W. E. R., Silman, A. J., Dawes, P., Hassell, A., ... Worthington, J. (1997). Tumor necrosis factor microsatellite haplotypes are different in male and female patients with RA. Journal of Rheumatology, 24(1), 217-219. . Publication link: d4099640-fd4a-4e2d-937f-59cfab70b6ac
  • John, S., Hajeer, A., Marlow, A., Myerscough, A., Silman, A. J., Ollier, W. E. R., & Worthington, J. (1997). Investigation of candidate disease susceptibility genes in rheumatoid arthritis: Principles and strategies. Journal of Rheumatology, 24(1), 199-201. . Publication link: bf3c9b72-c59b-44b5-8395-0d6e916c8b93
  • John, S., Marlow, A., Hajeer, A., Ollier, W., Silman, A., & Worthington, J. (1997). Linkage and association studies of the natural resistance associated macrophage protein 1 (NRAMP1) locus in rheumatoid arthritis. Journal of Rheumatology, 24(3), 452-457. . Publication link: adef5f20-33b5-4e6d-b2bc-784a54f13f19
  • Lazarus, M., Hajeer, A. H., Turner, D., Sinnott, P., Worthington, J., Ollier, W. E. R., & Hutchinson, I. V. (1997). Genetic variation in the interleukin 10 gene promoter and systemic lupus erythematosus. Journal of Rheumatology, 24(12), 2314-2317. . Publication link: d342279b-f75d-4db6-9a5c-eb70df24483d
  • Marlow, A., John, S., Hajeer, A., Ollier, W. E. R., Silman, A. J., & Worthington, J. (1997). The sensitivity of different analytical methods to detect disease susceptibility genes in rheumatoid arthritis sibling pair families. Journal of Rheumatology, 24(1), 208-211. . Publication link: 3066f82a-913a-4dda-863b-c90691840b5d
  • Ollier, W. E. R., & Worthington, J. (1997). New horizons in rheumatoid arthritis genetics. Journal of Rheumatology, 24(1), 193. . Publication link: 9583b128-c252-4ced-86cd-d69e26d1e85f
  • Ollier, W., & Worthington, J. (1997). Small fish in a big pond.British Journal of Rheumatology, 36(9), 931-932. . Publication link: 7d028096-9f8c-465a-b431-60b31c1e6bfa


  • Hajeer, A. H., Worthington, J., Silman, A. J., & Ollier, W. E. R. (1996). Association of tumor necrosis factor microsatellite polymorphisms with HLA-DRB1*04-bearing haplotypes in rheumatoid arthritis patients. Arthritis and Rheumatism, 39(7), 1109-1114. DOI:10.1002/art.1780390706. Publication link: 11ab7992-0c4d-48fe-b3ef-7af5ea3ac411


  • Silman, A. J., Hay, E. M., Worthington, J., Thomson, W., Pepper, L., Davidson, J., ... Ollier, W. E. R. (1995). Lack of influence of non-inherited maternal HLA-DR alleles on susceptibility to rheumatoid arthritis. Annals of the Rheumatic Diseases, 54(4), 311-313. . Publication link: 7cfb3bb6-6d6e-4903-b4b8-24f41fffb037


  • Turner, S., Ollier, W. E. R., Morgan, K., Worthington, J., & Wordsworth, P. (1993). Frequency of alleles of type II collagen in collagen antibody-positive rheumatoid arthritis patients [8]. British Journal of Rheumatology, 32(12), 1117-1118. . Publication link: 5d6a6245-b81b-4099-b23c-4dd6d9a1f7a8
  • Worthington, J., Rigby, A. S., MacGregor, A. J., Silman, A. J., Carthy, D., & Ollier, W. E. R. (1993). Lack of association of increased antibody levels to mycobacterial hsp65 with rheumatoid arthritis: Results from a study of disease discordant twin pairs. Annals of the Rheumatic Diseases, 52(7), 542-544. DOI:10.1136/ard.52.7.542. Publication link: 83d0d39c-7a3e-4980-95ca-140ecb528068

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