Professor David Denning FRCP FRCPath DCH FMedSci

Photograph of David Denning

Professor of Infectious Diseases in Global Health

  • Email:
  • Telephone: +44 (0)161 291 5818
  • Alternative Telephone: +44 (0) 161 291 5811 (Secretary)
  • Fax: +44 (0) 161 291 5806

Education and Research Centre
University Hospital of South Manchester
Southmoor Road
M23 9LT


Principal Investigator, Manchester Fungal infection Group

Director, National Aspergillosis Centre, based at University Hospital of South Manchester.

Managing Editor, The Aspergillus Website

President, Global Action Fund for Fungal infections (GAFFI)



Over 300 million people worldwide suffer from serious fungal infections. Aspergillus causes 100,000s of life-threatening infections worldwide and millions of allergic and chronic infections, with much morbidity. Over the past few decades, the incidence of invasive aspergillosis has risen steadily. It is now the most common invasive mould infection worldwide. Mortality is almost 100% if the disease is left untreated and high (40 to 90%)  with therapy. Invasive aspergillosis occurs in 5 to 25% of all leukemia patients and is the leading infectious cause of death in many transplant centres. Over 4.8 million are estimated to suffer from allergic aspergillosis complicating asthma. Aspergillus fumigatus is the most common responsible species, causing approximately 90% of human Aspergillus infections.

As well as the clinical aspects of medical mycology including diagnostics and the role of filamentous fungi in various forms of severe allergy, research carried out in the Manchester Fungal Infection Group group ranges from genomics through to diagnostics and studies of new antifungal drugs. Current collaboration with the JC Venter [genomics] Institute involve the sequencing and comparative analysis of multiple isolates of A. fumigatus.

Projects in the laboratory include studies of the frequency and mechanisms of azole drug resistance, human genetic variants underlying the different aspergillus diseases, the role of Aspergillus pathogenicity factors in infection using knockout mutants, and identification of novel drug targets. A substantial effort goes into evaluation of new antifungal drugs and diagnostics clinically and in the clinical laborarory.  The Aspergillus Website has been developed to enable the dissemination of medical and scientific information about Aspergillus and aspergillosis

Work is or has been supported by the Wellcome Trust, National Institute of Allergy and Infectious Diseases (USA), the EU, the Moulton Trust, the Medical Research Council, the Fungal Research Trust, National Institute for Health Research and the Chronic Granulomatous Disease Research Trust.

The impact of completed research is summarised here:  


Most teaching involves project options students and postgaduate research students.

Externally, expertise on chronic and allergic aspergillosis and the treatment of fungal disease is shared with doctors all over the world.

Leading Fungal infection International (LIFE) is one of many resources available worldwide. 

Social Responsibility

Leading International Fungal Education (LIFE) at

Global Action Fund for Fungal Infections at


  • Practising physician at one of Manchester's University Hospitals with expertise in fungal infections, particularly aspergillosis, antifungal resistance, the treatment of fungal infection and infection in the immunocompromised patient
  • Graduate of Guys Hospital London in 1980, with training in medicine, paediatrics, gastroenteroloy, haematology, infectious diseases and clinical microbiology, including a 3 year fellowship at Stanford University with Professor David Stevens (1987-1990)
  • Author of >450 research papers and chapters, mostly on fungal disease, resistance in fungi and treatment of fungal infection.
  • Co-author of ‘Medicine' with Professor Paul O'Neil and Dr Tim Dornan, an undergraduate textbook of medicine now in its third edition (2008).
  • Google H-index of 100
  • Personal citation index of >47,500 
  • Research grant income to Manchester University >£22M since 1990
  • Director of National Aspergillosis Centre,  based at University Hospital of South Manchester, Wythenshawe Hospital.
  • Co-ordinator of the International Genome Sequencing project for Aspergillus fumigatus (funded by NIH, Wellcome Trust and Spanish government) 1997-2005
  • Founder and Editor of Aspergillus website (1998-)
  • Consultant (current or past) to multiple pharmaceutical companies with regard to antifungal drug discovery including Merck, Pfizer, Schering Plough, Oxford Glycosciences and Astellas.
  • Founder of F2G Ltd, an antifungal drug discovery company spun out from Manchester University (1998-).
  • Founder and Chief Medical Officer of Myconostica (acquired by Trinity Biotech), developing and commercialising molecular diagnostics for fungal disease (2006-2011).
  • Listed in Who's Who in the World since 1996/7 Listed in Who's Who in Healthcare since 1997 Listed in Who's Who in Science and Technology since 2005, in Who's Who 2013-
  • Chairman of several international conferences (Trends in Invasive Fungal Infection (x3 1993, 1997 and 1999; Advances against Aspergillosis x6 2004, 2006, 2008, 2010 and 2012, 2014, 2016: Aspergillus Genetics and Genomes Focus Meeting 2004, and other smaller meetings) and sessions at major congresses.
  • MacFarlane Burnett Lecturer to the Australasian Society of Infectious Diseases, 2005.

  • Keynote plenary speaker at the European Conference on Clinical Microbiology and Infectious Diseases, 2008; International Society for Human and Animal Mycology, Tokyo, 2009; Asian Mycological Congress, Beijing, 2013; Trends in Medical Mycology, Copenhagen, 2013, International Union of Microbiological Societies, Montreal, 2014.

  • Director of the Leading International Fungal Education (LIFE) program on behalf of the Fungal Infection Trust, 2012 –

  • Founding President of Global Action Fund for Fungal Infections (GAFFI) in Geneva, 2013 - .



Collaborators and affiliated staff

Principal investigators in the Manchester Fungal Infection Group include:



  • Oladele, R., Alani S. Akanmu , Augustina O. Nwosu, Folasade T. Ogunsola, Richardson, M., & Denning, D. (2016). Cryptococcal Antigenemia in Nigerian Patients With Advanced Human Immunodeficiency Virus: Influence of Antiretroviral Therapy Adherence. Open Forum Infectious Diseases , 3(2), [ofw055]. DOI:10.1093/ofid/ofw055. Publication link: 5cf99c33-ff19-4129-8df1-5af927b7076c




  • Agarwal, R., Chakrabarti, A., Shah, A., Gupta, D., Meis, J. F., Guleria, R., ... Chopra, V. (2013). Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 43(8), 850-873. DOI:10.1111/cea.12141. Publication link: cbd63d7b-2040-4a66-af93-fc9857762d0c | PubMed:23889240
  • Al-Shair, K., Atherton, G. T. W., Kennedy, D., Powell, G., Denning, D. W., & Caress, A. (2013). Validity and reliability of the St. George's respiratory questionnaire in assessing health status in patients with chronic pulmonary aspergillosis. Chest, 144(2), 623-631. DOI:10.1378/chest.12-0014. Publication link: 17c68c80-fa2f-4de9-bda4-429f2ed879ff | PubMed:23188518
  • Al-Shair, K., Atherton, G. T., Harris, C., Ratcliffe, L., Newton, P. J., & Denning, D. W. (2013). Long-term antifungal treatment improves health status in patients with chronic pulmonary aspergillosis: a longitudinal analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 57(6), 828-835. DOI:10.1093/cid/cit411. Publication link: 84b33eb5-1b48-4b10-ba25-4b94e8fb21d7 | PubMed:23788240
  • Baxter, C. G., Denning, D. W., Jones, A. M., Todd, A., Moore, C. B., & Richardson, M. D. (2013). Performance of two Aspergillus IgG EIA assays compared with the precipitin test in chronic and allergic aspergillosis. Clinical Microbiology and Infection, 19(4), E197-E204. DOI:10.1111/1469-0691.12133. Publication link: 79488f6a-abfb-4537-8d35-8598fbf01936 | PubMed:23331929
  • Baxter, C. G., Dunn, G., Jones, A. M., Webb, K., Gore, R., Richardson, M. D., & Denning, D. W. (2013). Novel immunologic classification of aspergillosis in adult cystic fibrosis.The Journal of allergy and clinical immunology, 132(3), 560-e10. DOI:10.1016/j.jaci.2013.04.007. Publication link: 23b52173-a5bf-4f3c-934a-00bcc774242c | PubMed:23726262
  • Baxter, C. G., Moore, C. B., Jones, A. M., Webb, A. K., & Denning, D. W. (2013). IgE-mediated immune responses and airway detection of Aspergillus and Candida in adult cystic fibrosis. Chest, 143(5), 1351-1357. DOI:10.1378/chest.12-1363. Publication link: acc2ed10-023a-4f16-802b-a41bc73385ee | PubMed:23139075
  • Buied, A., Moore, C. B., Denning, D. W., & Bowyer, P. (2013). High-level expression of cyp51B in azole-resistant clinical aspergillus fumigatus isolates. Journal of Antimicrobial Chemotherapy, 68(3), 512-514. DOI:10.1093/jac/dks451. Publication link: b340d15c-63f0-4410-b39e-34ec27c6148a | PubMed:23208831
  • Denning, D. W., & Bowyer, P. (2013). Voriconazole resistance in Aspergillus fumigatus: Should we be concerned?. Clinical Infectious Diseases, 57(4), 521-523. DOI:10.1093/cid/cit321. Publication link: 36969ac6-f5af-4099-8ebf-e8ebf39182df | PubMed:23667265
  • Denning, D. W., Pleuvry, A., & Cole, D. C. (2013). Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults. Medical Mycology, 51(4), 361-370. DOI:10.3109/13693786.2012.738312. Publication link: 528f7418-928d-4954-bb74-596132a84cbf | PubMed:23210682
  • Denning, D. W., Pleuvry, A., & Cole, D. C. (2013). Global burden of chronic pulmonary aspergillosis complicating sarcoidosis. European Respiratory Journal, 41(3), 621-626. DOI:10.1183/09031936.00226911. Publication link: f3ae80a7-ff0d-4296-8674-8822c43b6f29 | PubMed:22743676
  • Farid, S., Mohamed, S., Devbhandari, M., Kneale, M., Richardson, M., Soon, S. Y., ... Rammohan, K. (2013). Results of surgery for chronic pulmonary Aspergillosis, optimal antifungal therapy and proposed high risk factors for recurrence--a National Centre's experience.Journal of Cardiothoracic Surgery, 8. DOI:10.1186/1749-8090-8-180. Publication link: fae6102a-b19c-4fed-aeb8-d52cd0cc2d08 | PubMed:23915502
  • Fraczek, M. G., Bromley, M., Buied, A., Moore, C. B., Rajendran, R., Rautemaa, R., ... Richardson, R-R. (2013). The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus.The Journal of antimicrobial chemotherapy, 68(7), 1486-1496. DOI:10.1093/jac/dkt075. Publication link: c352cffd-6ba1-453f-b108-859de2836232 | PubMed:23580559
  • Hayes, G. E., & Denning, D. W. (2013). Frequency, diagnosis and management of fungal respiratory infections. Current Opinion in Pulmonary Medicine, 19(3), 259-265. DOI:10.1097/MCP.0b013e32835f1ad1. Publication link: 5ff252bb-5447-4c9a-bc02-48f4c05479fc | PubMed:23411576
  • Haylett, A. K., Felton, S., Denning, D. W., & Rhodes, L. E. (2013). Voriconazole-induced photosensitivity: Photobiological assessment of a case series of 12 patients. British Journal of Dermatology, 168(1), 179-185. DOI:10.1111/j.1365-2133.2012.11196.x. Publication link: edffa516-ed91-4e38-a860-89504bec7b3a | PubMed:22860570
  • Howard, S. J., Pasqualotto, A. C., Anderson, M. J., Leatherbarrow, H., Albarrag, A. M., Harrison, E., ... Denning, D. W. (2013). Major variations in Aspergillus fumigatus arising within aspergillomas in chronic pulmonary aspergillosis. Mycoses, 56(4), 434-441. DOI:10.1111/myc.12047. Publication link: 74d12d4a-38fb-4920-b5a0-ed46980f404f | PubMed:23369025
  • Richardson, R-R., Baxter, C. G., Rautemaa, R., Jones, A. M., Kevin Webb, A., Bull, M., ... Denning, D. W. (2013). Intravenous antibiotics reduce the presence of Aspergillus in adult cystic fibrosis sputum. Thorax, 68(7), 652-657. DOI:10.1136/thoraxjnl-2012-202412. Publication link: 0b73d500-cfb9-4e73-862e-3512363730c1 | PubMed:23513028


  • Aquino, V. R., Nagel, F., Andreolla, H. F., de-Paris, F., Xavier, M. O., Goldani, L. Z., ... Pasqualotto, A. C. (2012). The Performance of Real-Time PCR, Galactomannan, and Fungal Culture in the Diagnosis of Invasive Aspergillosis in Ventilated Patients with Chronic Obstructive Pulmonary Disease (COPD). Mycopathologia, 174(2), 163-169. DOI:10.1007/s11046-012-9531-1. Publication link: 5c5456ac-8c91-420b-8c1b-ad1ab3de333c | PubMed:22382738
  • Bowyer, P., Mosquera, J., Anderson, M., Birch, M., Bromley, M., & Denning, D. W. (2012). Identification of novel genes conferring altered azole susceptibility in Aspergillus fumigatus. FEMS Microbiology Letters, 332(1), 10-19. DOI:10.1111/j.1574-6968.2012.02575.x. Publication link: f48b8eeb-3be1-4ea1-80e0-83329a483b9a | PubMed:22509997
  • Brown, G. D., Denning, D. W., Gow, N. A. R., Levitz, S. M., Netea, M. G., & White, T. C. (2012). Hidden killers: Human fungal infections. Science Translational Medicine, 4(165), [165rv13]. DOI:10.1126/scitranslmed.3004404. Publication link: 8685d648-e725-4140-9951-a221ec46e01f | PubMed:23253612
  • Chishimba, L., Niven, R. M., Cooley, J., & Denning, D. W. (2012). Voriconazole and posaconazole improve asthma severity in allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization. Journal of Asthma, 49(4), 423-433. DOI:10.3109/02770903.2012.662568. Publication link: 0f3f2a7c-fa71-4b31-a351-11a347b2ed24 | PubMed:22380765
  • Chrdle, A., Mustakim, S., Bright-Thomas, R. J., Baxter, C. G., Felton, T., & Denning, D. W. (2012). Aspergillus bronchitis without significant immunocompromise. Annals of the New York Academy of Sciences, 1272(1), 73-85. DOI:10.1111/j.1749-6632.2012.06816.x. Publication link: d9ee4034-8649-45c2-bf6c-86d0570cfa61 | PubMed:23231717
  • Gould, F. K., Denning, D. W., Elliott, T. S. J., Foweraker, J., Perry, J. D., Prendergast, B. D., ... Watkin, R. W. (2012). Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults: A report of the working party of the british society for antimicrobial chemotherapy. Journal of Antimicrobial Chemotherapy, 67(2), 269-289. [dkr450]. DOI:10.1093/jac/dkr450. Publication link: da69592b-0716-449d-9c81-abdb84592731 | PubMed:22086858
  • Harrison, E., Singh, A., Morris, J., Smith, N. L., Fraczek, M. G., Moore, C. B., ... Overton, N. (2012). Mannose-binding lectin genotype and serum levels in patients with chronic and allergic pulmonary aspergillosis. International Journal of Immunogenetics, 39(3), 224-232. DOI:10.1111/j.1744-313X.2011.01078.x. Publication link: ac861ded-385f-47ac-a018-eb4b762c6744 | PubMed:22225939
  • Joardar, V., Abrams, N. F., Hostetler, J., Paukstelis, P. J., Pakala, S., Pakala, S. B., ... Nierman, W. C. (2012). Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability. BMC Genomics, 13(1), [698]. DOI:10.1186/1471-2164-13-698. Publication link: ced70858-d004-48d8-a82b-583865743c11 | PubMed:23234273
  • Knutsen, A. P., Bush, R. K., Demain, J. G., Denning, D. W., Dixit, A., Fairs, A., ... Wardlaw, A. J. (2012). Fungi and allergic lower respiratory tract diseases. Journal of Allergy and Clinical Immunology, 129(2), 280-291. DOI:10.1016/j.jaci.2011.12.970. Publication link: 2566c1e1-f47c-48d6-9a91-8685efe53059 | PubMed:22284927
  • Pendleton, M., & Denning, D. W. (2012). Multifocal pulmonary aspergillomas: Case series and review. Annals of the New York Academy of Sciences, 1272(1), 58-67. DOI:10.1111/j.1749-6632.2012.06827.x. Publication link: 09bd6466-6373-4ded-a322-12023a699bb6 | PubMed:23231715


  • Adamama-Moraitou, K. K., Pardali, D., Day, M. J., Denning, D. W., Papazoglou, L., Papastefanou, A., & Rallis, T. S. (2011). Aspergillus fumigatus bronchopneumonia in a hellenic shepherd dog. Journal of the American Animal Hospital Association, 47(2), e13-e18. DOI:10.5326/JAAHA-MS-5497. Publication link: d4961711-d141-4f9f-b75d-5989ceaee360
  • Albarrag, A. M., Anderson, M. J., Howard, S. J., Robson, G. D., Warn, P. A., Sanglard, D., & Denning, D. W. (2011). Interrogation of related clinical pan-azole resistant Aspergillus fumigatus strains – G138C, Y431C and G434C SNPs in cyp51A, Upregulation of cyp51A and integration and activation of transposon Atf1 into cyp51A promoter.J Clin Microbiol, 55, 5113-5121. . Publication link: d21e7b78-8fc7-4bbc-a4f0-a7ec19277cec
  • Albarrag, A. M., Anderson, M. J., Howard, S. J., Robson, G. D., Warn, P. A., Sanglard, D., & Denning, D. W. (2011). Interrogation of related clinical pan-azole-resistant Aspergillus fumigatus strains: G138C, Y431C, and G434C single nucleotide polymorphisms in cyp51A, upregulation of cyp51A, and integration and activation of transposon Atf1 in the cyp51A promoter. Antimicrobial Agents and Chemotherapy, 55(11), 5113-5121. DOI:10.1128/AAC.00517-11. Publication link: a7b3bc56-7917-4ae6-b99d-3e8acf2a2bdd | PubMed:21876055
  • Baxter, C. G., Bishop, P., Low, S. E., Baiden-Amissah, K., & Denning, D. W. (2011). Pulmonary aspergillosis: An alternative diagnosis to lung cancer after positive [18F]FDG positron emission tomography. Thorax, 66(7), 638-640. DOI:10.1136/thx.2010.155515. Publication link: 8d5f0652-d76e-487a-b8ed-7bf991b2224b
  • Baxter, C. G., Jones, A. M., Webb, K., & Denning, D. W. (2011). Homogenisation of cystic fibrosis sputum by sonication - An essential step for Aspergillus PCR. Journal of Microbiological Methods, 85(1), 75-81. DOI:10.1016/j.mimet.2011.01.024. Publication link: 8209fd2f-8d79-439c-9137-b16ab9bebab6
  • Baxter, C. G., Marshall, A., Roberts, M., Felton, T. W., & Denning, D. W. (2011). Peripheral neuropathy in patients on long-term triazole antifungal therapy. Journal of Antimicrobial Chemotherapy, 66(9), 2136-2139. [dkr233]. DOI:10.1093/jac/dkr233. Publication link: da835f78-f946-436e-9770-9ee1afdfa3a4 | PubMed:21685202
  • Denning, D. W., Park, S., Lass-Florl, C., Fraczek, M. G., Kirwan, M., Gore, R., ... Perlin, D. S. (2011). High-frequency triazole resistance found in nonculturable aspergillus fumigatus from lungs of patients with chronic fungal disease. Clinical Infectious Diseases, 52(9), 1123-1129. DOI:10.1093/cid/cir179. Publication link: f8afcdd3-68c7-4abe-bc7d-9eb38815e237 | PubMed:21467016
  • Denning, D. W., Pleuvry, A., & Cole, D. C. (2011). Global burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis. Bulletin of the World Health Organization, 89(12), 864-872. DOI:10.2471/BLT.11.089441. Publication link: 5befdc5e-f644-43fe-9ed9-0d633778cb27 | PubMed:22271943
  • Denning, D. W., Pleuvry, A., & Cole, D. C. (2011). Global burden of chronic pulmonary aspergillosis as a sequel to tuberculosis.Bulletin WHO, 89, 864-872. . Publication link: 26cc0a34-388c-4ae3-b1fc-da34da3620d6
  • Gargani, Y., Bishop, P., & Denning, D. W. (2011). Too many mouldy joints - marijuana and chronic pulmonary aspergillosis. Mediterranean Journal of Hematology and Infectious Diseases, 3(1), [e2011005]. DOI:10.4084/MJHID.2011.005. Publication link: 6373a410-8113-498a-8fb1-51987292c9ff | PubMed:21625309
  • Hauser, P. M., Bille, J., Lass-Flörl, C., Geltner, C., Feldmesser, M., Levi, M., ... Denning, D. W. (2011). Multicenter, prospective clinical evaluation of respiratory samples from subjects at risk for Pneumocystis jirovecii infection by use of a commercial real-time PCR assay. Journal of Clinical Microbiology, 49(5), 1872-1878. DOI:10.1128/JCM.02390-10. Publication link: 111792c2-bcf4-4dd7-a89e-9901385e560f
  • Hogan, C., & Denning, D. W. (2011). Allergic bronchopulmonary aspergillosis and related allergic syndromes. Seminars in Respiratory and Critical Care Medicine, 32(6), 682-692. DOI:10.1055/s-0031-1295716. Publication link: 45cac650-bb7b-4504-8326-013b82237e14 | PubMed:22167396
  • Howard, S. J., Harrison, E., Bowyer, P., Varga, J., & Denning, D. W. (2011). Cryptic species and azole resistance in the Aspergillus niger complex. Antimicrobial Agents and Chemotherapy, 55(10), 4802-4809. DOI:10.1128/AAC.00304-11. Publication link: 5a49a1a7-5b91-4727-8213-2c093441ab35 | PubMed:21768508
  • Lass-Flörl, C., Follett, S. A., Moody, A., & Denning, D. W. (2011). Detection of aspergillus in lung and other tissue samples using the mycassay aspergillus real-time PCR kit. Canadian Journal of Microbiology, 57(9), 765-768. DOI:10.1139/w11-064. Publication link: e5cd9562-25cc-4cfd-aa9d-66beb9752d45 | PubMed:21861765
  • Purcell, J., McKenna, J., Critten, P., Denning, D. W., & Hassan, I. A. (2011). Mixed mould species in laboratory cultures of respiratory specimens: How should they be reported, and what are the indications for susceptibility testing?. Journal of Clinical Pathology, 64(6), 543-545. DOI:10.1136/jcp.2010.084517. Publication link: 9e3329c8-d1a2-4777-ad2d-c61b52eb13aa
  • Richardson, M., Bowyer, P., Moore, C. B., Rautemaa, R., Denning, D. W., Richardson, M. D., & Richardson, R-R. (2011). Azole antifungal resistance today: Focus on Aspergillus. Current Infectious Disease Reports, 13(6), 485-491. DOI:10.1007/s11908-011-0218-4. Publication link: ce72b308-23bd-4309-8219-9988263a186f | PubMed:21931980
  • Slater, J. L., Gregson, L., Denning, D. W., & Warn, P. A. (2011). Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice. Medical Mycology, 49(1), S107-S113. DOI:10.3109/13693786.2010.523852. Publication link: 57703dee-52a9-41cd-ac69-e4a280400a6b | PubMed:20950221
  • Smith, N. L., Denning, D. W., & Overton, N. (2011). Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma. European Respiratory Journal, 37(4), 865-872. DOI:10.1183/09031936.00054810. Publication link: dfedb6ce-94b5-48bc-9c4c-67562d6ba754 | PubMed:20595150
  • Tuckwell, D., Denning, D. W., & Bowyer, P. (2011). A public resource for metabolic pathway mapping of Aspergillus fumigatus Af293. Medical Mycology, 49(1), S114-S119. DOI:10.3109/13693786.2010.490243. Publication link: 249ceacc-a452-49f2-bcb5-3688712ff820 | PubMed:20507264


  • Ann Chai, L. Y., Denning, D. W., & Warn, P. (2010). Candida tropicalis in human disease. Critical Reviews in Microbiology, 36(4), 282-298. DOI:10.3109/1040841X.2010.489506. Publication link: 05bc6d97-11d1-4aec-8dba-ee5eb066ddf0 | PubMed:20883082
  • Dannaoui, E., Schwarz, P., Slany, M., Loeffler, J., Jorde, A. T., Cuenca-Estrella, M., ... Lortholary, O. (2010). Molecular detection and identification of Zygomycetes species from paraffin-embedded tissues in a murine model of disseminated zygomycosis: A collaborative European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG) evaluation. Journal of Clinical Microbiology, 48(6), 2043-2046. DOI:10.1128/JCM.02319-09. Publication link: ad581e4d-0071-4a23-8286-6172614896b3 | PubMed:20375233
  • Denning, D. W., & Hope, W. W. (2010). Therapy for fungal diseases: Opportunities and priorities. Trends in Microbiology, 18(5), 195-204. DOI:10.1016/j.tim.2010.02.004. Publication link: ba77e8d4-c6d5-4376-bf93-45aaa3003fb8
  • Felton, T. W., Baxter, C., Moore, C. B., Roberts, S. A., Hope, W. W., & Denning, D. W. (2010). Efficacy and safety of posaconazole for chronic pulmonary aspergillosis. Clinical Infectious Diseases, 51(12), 1383-1391. DOI:10.1086/657306. Publication link: e7b091c5-98f2-4dcd-a54b-fccb179f2fcb
  • Felton, T. W., Plested, V., Walsham, A., Dark, P., O'Driscoll, R., & Denning, D. W. (2010). A 27-year-old woman with acute, severe asthma who developed respiratory failure. Chest, 137(3), 724-727. DOI:10.1378/chest.09-1795. Publication link: 36458218-6630-404a-a237-b322123f47f6 | PubMed:20202956
  • Fraczek, M. G., Rashid, R., Denson, M., Denning, D. W., & Bowyer, P. (2010). Aspergillus fumigatus allergen expression is coordinately regulated in response to hydrogen peroxide and cyclic AMP. Clinical and Molecular Allergy, 8, [15]. DOI:10.1186/1476-7961-8-15. Publication link: a245c27d-e6ff-41dd-afa8-b8d11f830b18 | PubMed:21047420
  • Hiemenz, J. W., Raad, I. I., Maertens, J. A., Hachem, R. Y., Saah, A. J., Sable, C. A., ... Walsh, T. J. (2010). Efficacy of caspofungin as salvage therapy for invasive aspergillosis compared to standard therapy in a historical cohort. European Journal of Clinical Microbiology and Infectious Diseases, 29(11), 1387-1394. DOI:10.1007/s10096-010-1013-0. Publication link: bb5c72cc-4d22-4ced-801e-f04748abdda1 | PubMed:20703506
  • Howard, S., Howard, S. J., Pasqualotto, A. C., & Denning, D. W. (2010). Azole resistance in allergic bronchopulmonary aspergillosis and Aspergillus bronchitis. Clinical Microbiology and Infection, 16(6), 683-688. DOI:10.1111/j.1469-0691.2009.02911.x. Publication link: 55809730-21e9-4eec-8ab9-aad55465cc4b | PubMed:19673966
  • Lestner, J. M., & Denning, D. W. (2010). Tremor: A newly described adverse event with long-term itraconazole therapy. Journal of Neurology, Neurosurgery and Psychiatry, 81(3), 327-329. DOI:10.1136/jnnp.2009.174706. Publication link: a1cd10c7-f3b5-493c-8e5f-4cc1aec7ba74


  • Chakrabarti, A., Denning, D. W., Ferguson, B. J., Ponikau, J., Buzina, W., Kita, H., ... Radotra, B. D. (2009). Fungal rhinosinusitis: A categorization and definitional schema addressing current controversies. Laryngoscope, 119(9), 1809-1818. DOI:10.1002/lary.20520. Publication link: 6165bb12-ca94-463f-9365-0d9405451548
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  • Mabey Gilsenan, J. E., Atherton, G., Bartholomew, J., Giles, P. F., Attwood, T. K., Denning, D. W., & Bowyer, P. (2009). Aspergillus genomes and the aspergillus cloud. Nucleic acids research., 37(1), D509-D514. DOI:10.1093/nar/gkn876. Publication link: 00abeceb-00fe-486c-b27d-02c7f45d63f0 | PubMed:19039001
  • Majithiya, J., Sharp, A., Parmar, A., Denning, D. W., & Warn, P. A. (2009). Efficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida krusei. Journal of Antimicrobial Chemotherapy, 63(1), 161-166. DOI:10.1093/jac/dkn431. Publication link: bc41d141-8cae-4a98-afae-bbc5ddd41c71 | PubMed:19008255
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  • Schelenz, S., Barnes, R. A., Kibbler, C. C., Jones, B. L., & Denning, D. W. (2009). Standards of care for patients with invasive fungal infections within the United Kingdom: A national audit. Journal of Infection, 58(2), 145-153. DOI:10.1016/j.jinf.2008.12.006. Publication link: 578b3499-0f23-4ab5-b271-e954cacf2444
  • Verweij, P. E., Howard, S. J., Melchers, W. J. G., & Denning, D. W. (2009). Azole-resistance in Aspergillus: Proposed nomenclature and breakpoints. Drug Resistance Updates, 12(6), 141-147. DOI:10.1016/j.drup.2009.09.002. Publication link: 75e5c52d-f157-4491-9565-131e6c46643c | PubMed:19879181
  • Warn, P. A., Sharp, A., Parmar, A., Majithiya, J., Denning, D. W., & Hope, W. W. (2009). Pharmacokinetics and pharmacodynamics of a novel triazole, isavuconazole: Mathematical modeling, importance of tissue concentrations, and impact of immune status on antifungal effect. Antimicrobial Agents and Chemotherapy, 53(8), 3453-3461. DOI:10.1128/AAC.01601-08. Publication link: b1eea609-58d0-4f25-8718-b6def08c499e | PubMed:19451288


  • Carvalho, A., Pasqualotto, A. C., Pitzurra, L., Romani, L., Denning, D. W., & Rodrigues, F. (2008). Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis. Journal of Infectious Diseases, 197(4), 618-621. DOI:10.1086/526500. Publication link: 721146a9-183e-4ff1-938c-26b571d7397f
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  • Hedayati, M. T., Pasqualotto, A. C., Warn, P. A., Bowyer, P., & Denning, D. W. (2007). Aspergillus flavus: Human pathogen, allergen and mycotoxin producer. Microbiology, 153(6), 1677-1692. DOI:10.1099/mic.0.2007/007641-0. Publication link: 7f6d8ddf-bbce-4de0-91f2-51df4c044e7f | PubMed:17526826
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  • Dodgson, A. R., Pujol, C., Pfaller, M. A., Denning, D. W., & Soll, D. R. (2005). Evidence for recombination in Candida glabrata. Fungal Genetics and Biology, 42(3), 233-243. DOI:10.1016/j.fgb.2004.11.010. Publication link: 27c687e2-9d27-4cbe-8ebf-66c4ec57076c
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  • O'Driscoll, B. R., Hopkinson, L. C., & Denning, D. W. (2005). Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions. BMC Pulmonary Medicine, 5, [4]. DOI:10.1186/1471-2466-5-4. Publication link: 36731c9a-11cd-495b-b391-53e12d9045e7
  • Paisley, D., Robson, G. D., & Denning, D. W. (2005). Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus. Medical Mycology, 43(5), 397-401. DOI:10.1080/13693780400005866. Publication link: 7081020f-89f9-418f-8d5e-bf87dec13508
  • Paoletti, M., Rydholm, C., Schwier, E. U., Anderson, M. J., Szakacs, G., Lutzoni, F., ... Dyer, P. S. (2005). Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus. Current Biology, 15(13), 1242-1248. DOI:10.1016/j.cub.2005.05.045. Publication link: 1d874820-ce5e-4754-aabb-f94dd05d3010
  • Patterson, T. F., Boucher, H. W., Herbrecht, R., Denning, D. W., Lortholary, O., Ribaud, P., ... Bennett, J. E. (2005). Strategy of following voriconazole versus amphoterian B therapy with other licensed antifungal therapy for primary treatment of invasive aspergillosis: Impact of other therapies on outcome. Clinical Infectious Diseases, 41(10), 1448-1452. DOI:10.1086/497126. Publication link: fcc601a6-d633-4644-a39a-9259025fb6b2
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  • Sambatakou, H., & Denning, D. W. (2005). Invasive pulmonary aspergillosis transformed into fatal mucous impaction by immune reconstitution in an AIDS patient. European Journal of Clinical Microbiology and Infectious Diseases, 24(9), 628-633. DOI:10.1007/s10096-005-0006-x. Publication link: 9d9a4a46-98f1-4d9a-bccf-7ee91de2abd6


  • Birch, M., Denning, D. W., & Robson, G. D. (2004). Comparison of extracellular phospholipase activities in clinical and environmental Aspergillus fumigatus isolates. Medical Mycology, 42(1), 81-86. DOI:10.1080/13693780310001610029. Publication link: b58124b3-cb53-48d9-b344-d9a9c71ec680
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  • Kamran, M., Calcagno, A. M., Findon, H., Bignell, E., Jones, M. D., Warn, P., ... Haynes, K. (2004). Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence. Eukaryotic Cell, 3(2), 546-552. DOI:10.1128/EC.3.2.546-552.2004. Publication link: b93f6d92-afc5-423e-8aac-a746a456dd51 | PubMed:15075283
  • Keevil, B. G., Newman, S., Lockhart, S., Howard, S. J., Moore, C. B., & Denning, D. W. (2004). Validation of an assay for voriconazole in serum samples using liquid chromatography-tandem mass spectrometry. Therapeutic Drug Monitoring, 26(6), 650-657. DOI:10.1097/00007691-200412000-00011. Publication link: 2299b8b3-d783-4b63-83de-2525deea61b5 | PubMed:15570190
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  • Sari-Houzel, H., Herrick, A. L., Chadwick, P. R., Muir, L. T. S., & Denning, D. W. (2004). Mycobacterium chelonae finger infection associated with Raynaud's phenomenon. Annals Of Rheumatic Diseases, 6. . Publication link: c1a4ad4d-b6ae-4a2c-80bd-f407ed57a9fe
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  • Zaspel, U., Denning, D. W., Lemke, A. J., Greene, R., Schürmann, D., Maschmeyer, G., ... Oestmann, J. W. (2004). Diagnosis of IPA in HIV: The role of the chest X-ray and radiologist. European Radiology, 14(11), 2030-2037. DOI:10.1007/s00330-004-2447-5. Publication link: 0d1e6613-a6ea-4aea-b09d-ad3a43f93550



  • Denning, D. W., Anderson, M. J., Turner, G., Latgé, J. P., & Bennett, J. W. (2002). Sequencing the Aspergillus fumigatus genome. Lancet Infectious Diseases, 2(4), 251-253. DOI:10.1016/S1473-3099(02)00243-8. Publication link: 27621cb3-7c73-4b3b-896d-f3d36bddbb1f
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