Professor Ian Bruce MD FRCP

Professor of Rheumatology

  • Email: ian.bruce@manchester.ac.uk
  • Telephone: +44 (0)161 275 1670 / 1639
  • Alternative Telephone: +44(0)161 276 4626 (Clinical secretary)

Arthritis Research UK Centre for Epidemiology
Centre for Musculoskeletal Research
Institute of Inflammation and Repair
Stopford Building
The University of Manchester
Oxford Road
Manchester
M13 9PT

Role

I am Professor of Rheumatology and an NIHR Senior Investigator at the Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair. 

My clinical work is as Lead Clinician at The Kellgren Centre for Rheumatology, Central Manchester and Manchester Children's University Hospitals Trust. I am also Medical Director of the NIHR Manchester Wellcome Trust Clinical Research Facility and Centre Academic Lead for the NIHR Translational Research Partnership in Joint and Related Inflammatory Diseases. 

I am the Director of the NIHR Manchester Musculoskeletal Biomedical Research Unit and the research theme lead for Connective Tissue Diseases.
 

Memberships of Committees and Professional Bodies

  • Fellow of the Royal College of Physicians of London
  • British Society for Rheumatology
  • American College of Rheumatology
  • Association of Physicians of Great Britain and Ireland
  • Chair: Systemic Lupus International Collaborating Clinics 

Research

My major research focus is on the association between inflammatory rheumatic diseases and premature atherosclerosis / coronary heart disease. In particular, my focus is on systemic lupus erythematosus and rheumatoid arthritis. I have been successful developing collaborations with a number of investigators from across the University including in Institute of Cardiovascular Sciences (Dr Y Alexander) and Renal Research (Prof P Brenchley). Through my membership of the Systemic Lupus International Collaborating Clinics and the British Isles Lupus Assessment Group, I also participate in a number of national and international multicentre studies that are seeking to refine our understanding of SLE, including a study funded by the Canadian Institute for Health Research on Metabolic Syndrome in SLE.
I am Co-PI on the Norfolk Arthritis Registry (NOAR), Cardiovascular Sub-study and also supervise 2 current MRC Clinical Pharmacology Training Fellows (Dr John Reynolds and Dr Sarah Skeoch). 
I am also committed to contributing to and participating in important collaborative studies and in the past few years I have been involved in the Wellcome Trust Case Control Consortium and the British Society for Rheumatology Biologics Registry Control Consortium. The studies arising from these collaborations have resulted in important advances in our understanding of the genetic basis of several common disease (WTCCC) as well as our understanding of the safety and long-term efficacy of biologic agents used in RA (BSRBR). 
I am Research Lead for the Connective Tissue Disease research theme of the NIHR Manchester Musculoskeletal Biomedical Research Unit.

Methodological Knowledge

  • Clinical Assessment Tools for Systemic Lupus Erythematosus
  • Observational Cohort Studies
  • Case-control Studies
  • Randomised Trials

Biography

I qualified in Medicine from Queen's University Belfast in 1988 and gained my MRCP in 1991. My clinical training in medicine and rheumatology was in Northern Ireland and I completed my MD Thesis on the pathogenesis of systemic vasculitis in 1995. From 1996-1998 I was the Geoff Carr Lupus Fellow at the University of Toronto ( Profs M Urowtiz and D Gladman). I moved to Manchester in 1998 initially as an NHS consultant but later transferred to the University in 2003. I was appointed Professor of Rheumatology in August 2010 and an NIHR Senior Investigator in April 2013. 

Collaborators and affiliated staff

  • Arthritis Research UK Epidemiology Unit: Prof D Symmons, Prof J Worthington, Prof A Barton, Prof W Thomson, Dr M Lunt
  • Institute of Cardiovascular Sciences: Dr Y Alexander  
  • Renal Research Laboratories Prof PEC Brenchley
  • Institute of Human Development: Dr C Tower, Prof C Sibley, Dr I Crocker

Publications

2016

  • Bruce, I. N., Urowitz, M., van Vollenhoven, R., Aranow, C., Fettiplace, J., Oldham, M., ... Gordon, D. (2016). Long-term organ damage accrual and safety in patients with SLE treated with belimumab plus standard of care.Lupus. DOI:10.1177/0961203315625119
    . Publication link: 843dcbaa-f725-43b8-8c1f-20603d0675e0 | PubMed:26936891
  • Hanly, J. G., O'Keeffe, A. G., Su, L., Urowitz, M. B., Romero-Diaz, J., Gordon, C., ... Farewell, V. (2016). The frequency and outcome of lupus nephritis: results from an international inception cohort study.Rheumatology (Oxford, England), 55(2), 252-262. DOI:10.1093/rheumatology/kev311
    . Publication link: 87dbd4cd-b7a7-4e10-aca8-055ca693c081 | PubMed:26342222
  • Hanly, J. G., Urowitz, M. B., Romero-Diaz, J., Bae, S-C., Bernatsky, S., Clarke, A. E., ... Farewell, V. (2016). A Longitudinal Analysis of Outcomes of Lupus Nephritis in an International Inception Cohort Using a Multistate Model Approach. Arthritis & rheumatology (Hoboken, N.J.). DOI:10.1002/art.39674
    . Publication link: b1b79b9c-4fde-4dcf-b24d-2ab18910fb70 | PubMed:26991067
  • McElhone, K., Abbott, J., Sutton, C., Mullen, M., Lanyon, P., Rahman, A., ... Teh, L-S. (2016). Sensitivity to Change (Responsiveness) and Minimal Important Differences of the LupusQoL in patients with Systemic Lupus Erythematosus.Arthritis care & research. DOI:10.1002/acr.22850
    . Publication link: d3572596-000f-4c2b-8097-b7815154285b | PubMed:26816223
  • Reynolds, J. A., Haque, S., Williamson, K., Ray, D. W., Alexander, M. Y., & Bruce, I. N. (2016). Vitamin D improves endothelial dysfunction and restores myeloid angiogenic cell function via reduced CXCL-10 expression in systemic lupus erythematosus.Scientific Reports, 6. DOI:10.1038/srep22341
    . Publication link: f29dbc6b-d58b-4ef1-aa4a-ff096befc5f1 | PubMed:26930567
  • Urowitz, M. B., Gladman, D. D., Su, J., Romero-Diaz, J., Bae, S. C., Fortin, P. R., ... Stoll, T. (2016). Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort. Lupus, 3(1), e000143. DOI:10.1136/lupus-2015-000143
    . Publication link: ba2224c8-3283-4962-93fe-4b9845c84f4b | PubMed:27099765
  • Wig, S., Chan, M., Thachil, J., Bruce, I., & Barnes, T. (2016). A case of relapsing and refractory catastrophic anti-phospholipid syndrome successfully managed with eculizumab, a complement 5 inhibitor.Rheumatology (Oxford, England), 55(2). DOI:10.1093/rheumatology/kev371
    . Publication link: 8b276744-aa2c-4d45-9dc2-e1db0e28c972 | PubMed:26472567

2015

  • Barraclough, M., Elliott, R., McKie, S., Parker, B., & Bruce, I. N. (2015). Cognitive dysfunction and functional magnetic resonance imaging in systemic lupus erythematosus.Lupus, 24(12), 1239-1247. DOI:10.1177/0961203315593819
    . Publication link: dfe2cd8f-f5f1-43e5-a6e9-d649be37dcd9 | PubMed:26124237
  • Bourre-Tessier, J., Urowitz, M. B., Sanchez-Guerrero, J., Fessler, B., Clarke, A. E., Alarcon, G. S., ... Romero-Diaz, J. (2015). Electrocardiographic findings in systemic lupus erythematosus: Data from an international inception cohort.Arthritis care & research, 67(1), 128-135. DOI:10.1002/acr.22370
    . Publication link: c589555d-50e6-41d4-9a0a-e4417ced417c | PubMed:24838943
  • Bowes, J., Budu-Aggrey, A., Bruce, I. N., Barton, A., Loehr, S., Uebe, S., ... Reis, A. (2015). PTPN22 is associated with susceptibility to psoriatic arthritis but not psoriasis: evidence for a further PsA-specific risk locus. Annals of the Rheumatic Diseases, 74(10), 1882-1885. DOI:10.1136/annrheumdis-2014-207187
    . Publication link: 06c81937-c397-451d-929d-1b016af09453
  • Bowes, J., Budu-Aggrey, A., Huffmeier, U., Uebe, S., Steel, K., Hebert, H. L., ... Barton, A. (2015). Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis.Nature communications, 6. DOI:10.1038/ncomms7046
    . Publication link: 51d24293-31b9-4811-95a2-c58d20442f39 | PubMed:25651891
  • Bruce, I. N., & Mulhearn, B. (2015). Indications for IVIG in rheumatic diseases. Rheumatology (Print), 54(3), 383-391. DOI:10.1093/rheumatology/keu429
    . Publication link: b8382f68-8c16-4e62-a841-ad36b18a5a5a
  • Hanly, J. G., Su, L., Urowitz, M. B., Romero-Diaz, J., Gordon, C., Bae, S-C., ... Farewell, V. (2015). Mood disorders in systemic lupus erythematosus: Results from an international, inception cohort study.Arthritis & rheumatology (Hoboken, N.J.), 67(7), 1837-47. DOI:10.1002/art.39111
    . Publication link: 21d8e7f9-1f69-439d-87d1-3978e35bde94 | PubMed:25778456
  • Mercer, L. K., Lunt, M., Low, A. L. S., Dixon, W. G., Watson, K. D., Symmons, D. P. M., ... Klimiuk, P. (2015). Risk of solid cancer in patients exposed to anti-tumour necrosis factor therapy: Results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis. Annals of the Rheumatic Diseases, 74(6), 1087-1093. DOI:10.1136/annrheumdis-2013-204851
    . Publication link: beeaf034-b42a-4f86-a625-f225c36d4a74 | PubMed:24685910
  • Morgan, C., Mcbeth, J., Cordingley, L., Hyrich, K. L., Bruce, I. N., Watson, K., ... McBeth, J. (2015). The Influence of behavioural and psychological factors on medication adherence over time in rheumatoid arthritis patients: A study in the biologics era.Rheumatology (Print), 54(10), 1780-1791.
    . Publication link: 73f26962-1453-4ad4-ac89-a77a5e39a31f
  • Orbai, A-M., Truedsson, L., Sturfelt, G., Nived, O., Fang, H., Alarcón, G., ... Petri, M. (2015). Anti-C1q antibodies in systemic lupus erythematosus.Lupus, 24(1), 42-49. DOI:10.1177/0961203314547791
    . Publication link: 42824e48-8aae-488c-9c26-4b5065d94e00 | PubMed:25124676
  • Skeoch, S., & Bruce, I. N. (2015). Atherosclerosis in rheumatoid arthritis: is it all about inflammation?. Nature Reviews. Rheumatology, [Epub ahead of print].
    . Publication link: f55855c8-1f96-4dae-8a11-0c2c50c326bc

2014

  • Bluett, J., Ibrahim, I., Plant, D., Hyrich, K. L., Bruce, I., Kitas, G., ... Barton, A. (2014). Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: Results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Pharmacogenomics Journal, 14(2), 171-175. DOI:10.1038/tpj.2013.26
    . Publication link: a199e365-9e83-4464-bd9d-c2458feebf4d | PubMed:23856853
  • Bruce, I. N., O'Keeffe, A. G., Farewell, V., Hanly, J. G., Manzi, S., Su, L., ... Urowitz, M. B. (2014). Factors associated with damage accrual in patients with systemic lupus erythematosus: Results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort. Annals of the Rheumatic Diseases. DOI:10.1136/annrheumdis-2013-205171
    . Publication link: 9b26a5a6-1796-40ca-a443-7d3c1238689f | PubMed:24834926
  • Khamashta, M. A., Bruce, I. N., Gordon, C., Isenberg, D. A., Ateka-Barrutia, O., Gayed, M., ... Perna, A. (2014). The cost of care of systemic lupus erythematosus (SLE) in the UK: annual direct costs for adult SLE patients with active autoantibody-positive disease.Lupus, 23(3). DOI:10.1177/0961203313517407
    . Publication link: ec527e84-b068-4c90-a18f-004f97f6c471 | PubMed:24356612
  • Lahiri, M., Luben, R. N., Morgan, C., Bunn, D. K., Marshall, T., Lunt, M., ... Bruce, I. N. (2014). Using lifestyle factors to identify individuals at higher risk of inflammatory polyarthritis (results from the European Prospective Investigation of Cancer-Norfolk and the Norfolk Arthritis Register-the EPIC-2-NOAR Study). Annals of the Rheumatic Diseases, 73(1), 219-226. DOI:10.1136/annrheumdis-2012-202481
    . Publication link: 14cebf96-0f12-4e9e-a8b1-b6eeb070c5c9 | PubMed:23505230
  • Lertratanakul, A., Wu, P., Dyer, A., Urowitz, M., Gladman, D., Fortin, P., ... Ramsey-Goldman, R. (2014). 25-hydroxyvitamin D and cardiovascular disease in patients with systemic lupus erythematosus: Data from a large international inception cohort. Arthritis Care and Research, 66(8), 1167-1176. DOI:10.1002/acr.22291
    . Publication link: 434b3412-5822-4188-973e-9094378c2fad | PubMed:24470118
  • Meacock, R., Harrison, M., McElhone, K., Abbott, J., Haque, S., Bruce, I., ... Teh, L. S. (2014). Mapping the disease-specific LupusQoL to the SF-6D.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 24(7), 1749-1758. DOI:10.1007/s11136-014-0892-4
    . Publication link: 66236533-7473-4ad0-b0e2-f21b890e03e5 | PubMed:25510215
  • Mirjafari, H., Welsh, P., Verstappen, S. M. M., Wilson, P., Marshall, T., Edlin, H., ... Bruce, I. N. (2014). N-terminal pro-brain-type natriuretic peptide (NT-pro-BNP) and mortality risk in early inflammatory polyarthritis: Results from the Norfolk Arthritis Registry (NOAR). Annals of the Rheumatic Diseases, 73(4), 684-690. DOI:10.1136/annrheumdis-2012-202848
    . Publication link: d9309267-bd1f-473b-b406-027c4c58680d | PubMed:23511225
  • Parker, B., Al-Husain, A., Pemberton, P., Yates, A. P., Ho, P., Gorodkin, R., ... Bruce, I. N. (2014). Suppression of inflammation reduces endothelial microparticles in active systemic lupus erythematosus. Annals of the Rheumatic Diseases, 73(6), 1144-1150. DOI:10.1136/annrheumdis-2012-203028
    . Publication link: 1b58fa17-44d5-487b-ad09-0eb6b858fd55 | PubMed:23644670
  • Parker, B., Urowitz, M. B., Gladman, D. D., Lunt, M., Donn, R., Bae, S. C., ... Bruce, I. N. (2014). Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: Data from an international inception cohort. Annals of the Rheumatic Diseases. DOI:10.1136/annrheumdis-2013-203933
    . Publication link: 85d1ef37-c05d-4913-ae5d-e60cec6fd05d | PubMed:24692585
  • Reynolds, J. A., Ray, D. W., Zeef, L. A. H., O'Neill, T., Bruce, I. N., & Alexander, M. Y. (2014). The effect of type 1 IFN on human aortic endothelial cell function in vitro: Relevance to systemic lupus erythematosus. Journal of Interferon and Cytokine Research, 34(5), 404-412. DOI:10.1089/jir.2013.0016
    . Publication link: f5fe03b1-1226-4b3f-bd63-c2a1f519d3a7 | PubMed:24444308
  • Reynolds, J. A., Robertson, A. C., Bruce, I. N., & Alexander, M. Y. (2014). Improving cardiovascular outcomes in rheumatic diseases: Therapeutic potential of circulating endothelial progenitor cells. Pharmacology and Therapeutics, 142(2), 231-243. DOI:10.1016/j.pharmthera.2013.12.008
    . Publication link: 73634b85-8d51-47d4-8c57-f0741637252f | PubMed:24333265
  • Skeoch, S., Haque, S., Pemberton, P., & Bruce, I. N. (2014). Cell adhesion molecules as potential biomarkers of nephritis, damage and accelerated atherosclerosis in patients with SLE. Lupus, 23(8), 819-824. DOI:10.1177/0961203314528061
    . Publication link: 30e7f595-1310-480a-9313-3fd351e3a992 | PubMed:24647443
  • Urowitz, M. B., Gladman, D. D., Ibañez, D., Sanchez-Guerrero, J., Romero-Diaz, J., Gordon, C., ... Stoll, T. (2014). American college of rheumatology criteria at inception, and accrual over 5 years in the slicc inception cohort. Journal of Rheumatology, 41(5), 875-880. DOI:10.3899/jrheum.130704
    . Publication link: f52b531e-2fce-456a-96e5-639beb08c8f9 | PubMed:24692526
  • Urowitz, M., Gladman, D. D., Ibañez, D., Sanchez-Guerrero, J., Bae, S. C., Gordon, C., ... Stoll, T. (2014). Changes in quality of life in the first 5 years of disease in a multicenter cohort of patients with systemic lupus erythematosus. Arthritis Care and Research, 66(9), 1374-1379. DOI:10.1002/acr.22299
    . Publication link: afc03c21-1874-43bf-b83f-a652c7b69e1b | PubMed:24497416
  • Van Vollenhoven, R. F., Mosca, M., Bertsias, G., Isenberg, D., Kuhn, A., Lerstrøm, K., ... Schneider, M. (2014). Treat-to-target in systemic lupus erythematosus: Recommendations from an international task force. Annals of the Rheumatic Diseases, 73(6), 958-967. DOI:10.1136/annrheumdis-2013-205139
    . Publication link: 1486bac7-c6f6-46a9-b0df-f1e8c8094dd4 | PubMed:24739325

2013

  • Alhusain, A., & Bruce, I. N. (2013). Cardiovascular risk and inflammatory rheumatic diseases. Clinical Medicine, Journal of the Royal College of Physicians of London, 13(4), 395-397. DOI:10.7861/clinmedicine.13-4-395
    . Publication link: 82460fb8-0f16-4b09-80f1-aaedcbe4a062 | PubMed:23908513
  • Apel, M., Uebe, S., Bowes, J., Giardina, E., Korendowych, E., Juneblad, K., ... Hüffmeier, U. (2013). Variants in RUNX3 Contribute to Susceptibility to Psoriatic Arthritis, Exhibiting Further Common Ground with Ankylosing Spondylitis. Arthritis and Rheumatism, 65(5), 1224-1231. DOI:10.1002/art.37885
    . Publication link: 3a731ed3-285d-4495-bb9a-589865b112f6 | PubMed:23401011
  • Bruce, I. (2013). Risk of rheumatoid arthritis linked to lifestyle. British Journal of Hospital Medicine, 74(4).
    . Publication link: 9d0118fd-258e-4861-9919-5dbd2533b18f
  • Chew, C., Pemberton, P. W., Husain, A. A. M., Haque, S., & Bruce, I. N. (2013). Serum cystatin C is independently associated with renal impairment and high sensitivity C-reactive protein in systemic lupus erythematosus. Clinical and Experimental Rheumatology, 31(2), 0251-0255.
    . Publication link: 01fcefc0-28f4-4091-8260-25aa461cba63 | PubMed:23306163
  • Green, L., Cookson, A., Bruce, I. N., Donn, R. P., & Ray, D. W. (2013). Identification of multiple, oxygen-stable HIF1 alpha isoforms, and augmented expression of adrenomedullin in rheumatoid arthritis. Clinical and Experimental Rheumatology, 31(5), 672-682.
    . Publication link: 513d182f-a785-447f-bd4a-27da129acfd5 | PubMed:23711352
  • Hanly, J. G., Urowitz, M. B., O'Keeffe, A. G., Gordon, C., Bae, S. C., Sanchez-Guerrero, J., ... Farewell, V. (2013). Headache in systemic lupus erythematosus: Results from a prospective, international inception cohort study. Arthritis and Rheumatism, 65(11), 2887-2897. DOI:10.1002/art.38106
    . Publication link: f1b7f161-b62d-47b7-bd87-31255ee3e7ef | PubMed:24166793
  • Haque, S., Rakieh, C., Marriage, F., Ho, P., Gorodkin, R., Teh, L. S., ... Bruce, I. N. (2013). Brief report: Shortened telomere length in patients with systemic lupus erythematosus. Arthritis and Rheumatism, 65(5), 1319-1323. DOI:10.1002/art.37895
    . Publication link: 4e9ee019-b7f2-4dd0-bd48-b479149e8b02 | PubMed:23400670
  • Heathfield, S. K., Parker, B., Zeef, L. A. H., Bruce, I. N., & Alexander, M. Y. (2013). Certolizumab pegol attenuates the pro-inflammatory state in endothelial cells in a manner that is atheroprotective. Clinical and Experimental Rheumatology, 31(2), 0225-0233.
    . Publication link: e3383eeb-2d36-413f-9733-e450bb023df3 | PubMed:23295110
  • Humphreys, J. H., Verstappen, S. M. M., Mirjafari, H., Bunn, D., Lunt, M., Bruce, I. N., & Symmons, D. P. M. (2013). Association of morbid obesity with disability in early inflammatory polyarthritis: Results from the Norfolk Arthritis Register. Arthritis Care and Research, 65(1), 122-126. DOI:10.1002/acr.21722
    . Publication link: 56fe6fd6-df4c-439c-97cb-d0687d52dde6 | PubMed:22556112
  • Owen, S. A., Hider, S. L., Martin, P., Bruce, I. N., Barton, A., & Thomson, W. (2013). Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients. Pharmacogenomics Journal, 13(3), 227-234. DOI:10.1038/tpj.2012.7
    . Publication link: 3a37e5d7-49d4-4b98-bac1-9ff6baa58bf0 | PubMed:22450926
  • Owen, S. A., Lunt, M., Bowes, J., Hider, S. L., Bruce, I. N., Thomson, W., & Barton, A. (2013). MTHFR gene polymorphisms and outcome of methotrexate treatment in patients with rheumatoid arthritis: Analysis of key polymorphisms and meta-analysis of C677T and A1298C polymorphisms. Pharmacogenomics Journal, 13(2), 137-147. DOI:10.1038/tpj.2011.42
    . Publication link: 7d971192-892c-43ed-8e87-3da9d3803525 | PubMed:21931346
  • Parker, B., & Bruce, I. (2013). SLE and metabolic syndrome.Lupus, 22(12), 1259-1266. DOI:10.1177/0961203313502570
    . Publication link: 7b6fb7fd-7584-41fb-867a-c92b230919f8 | PubMed:24097998
  • Parker, B., Urowitz, M. B., Gladman, D. D., Lunt, M., Bae, S. C., Sanchez-Guerrero, J., ... Bruce, I. N. (2013). Clinical associations of the metabolic syndrome in systemic lupus erythematosus: Data from an international inception cohort. Annals of the Rheumatic Diseases, 72(8), 1308-1314. DOI:10.1136/annrheumdis-2012-202106
    . Publication link: d55ffa47-05bc-4850-9187-4dd58cb63cbf | PubMed:22945501
  • Reynolds, J., Bruce, I. N., & J.A., . U. (2013). Overview of the management of systemic lupus erythematosus. Reports on the Rheumatic Diseases Series 7 - Topical Reviews, (2), 1-11.
    . Publication link: 2ed82183-68c0-43ea-aec2-5fb6c284a4d0
  • Sutton, E. J., Davidson, J. E., & Bruce, I. N. (2013). The Systemic Lupus International Collaborating Clinics (SLICC) damage index: A systematic literature review. Seminars in Arthritis and Rheumatism, 43(3), 352-361. DOI:10.1016/j.semarthrit.2013.05.003
    . Publication link: 3d7080a7-2521-449f-8d03-04a4f11be3c0 | PubMed:23786872
  • Tower, C., Mathen, S., Crocker, I., & Bruce, I. N. (2013). Regulatory T cells in Systemic Lupus Erythematosus and Pregnancy. American Journal of Reproductive Immunology, 69(6), 588-595. DOI:10.1111/aji.12081
    . Publication link: 07f23025-29b5-4c24-a2ee-6e3a432682ac | PubMed:23398158
  • Verstappen, S. M. M., Lunt, M., Luben, R. N., Chipping, J., Marshall, T., Khaw, K. T., ... Symmons, D. P. M. (2013). Demographic and disease-related predictors of abnormal lung function in patients with established inflammatory polyarthritis and a comparison with the general population. Annals of the Rheumatic Diseases, 72(9), 1517-1523. DOI:10.1136/annrheumdis-2012-201698
    . Publication link: fb591b44-9dbe-427a-913e-1ad711d989ae | PubMed:23065733

2012

  • Bowes, J., Ho, P., Flynn, E., Ali, F., Marzo-Ortega, H., Coates, L. C., ... Barton, A. (2012). Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.Annals of the rheumatic diseases, 71(8), 1350-1354. DOI:10.1136/annrheumdis-2011-200802
    . Publication link: 26cd6719-de85-4cc1-8e53-2c222646029a | PubMed:22328738
  • Bowes, J., Ho, P., Flynn, E., Salah, S., McHugh, N., FitzGerald, O., ... Barton, A. (2012). Investigation of IL1, VEGF, PPARG and MEFV genes in psoriatic arthritis susceptibility. Annals of the Rheumatic Diseases, 71(2), 313-314. DOI:10.1136/ard.2011.154690
    . Publication link: 08a96645-d7a4-4a7d-84b0-af203fa27d6f | PubMed:21803748
  • Chiu, Y., Ostor, A. J. K., Hammond, A., Sokoll, K., Anderson, M., Buch, M., ... Bruce, I. N. (2012). Access to the next wave of biologic therapies (Abatacept and Tocilizumab) for the treatment of rheumatoid arthritis in England and Wales Addressing treatment outside the current NICE guidance. Clinical Rheumatology, 31(6), 1005-1012. DOI:10.1007/s10067-011-1936-6
    . Publication link: 02d70102-41e9-4ec6-a977-6ea66cb56183 | PubMed:22271229
  • Guerry, M. J. C. J., Brogan, P., Bruce, I. N., D'Cruz, D. P., Harper, L., Luqmani, R., ... Jayne, D. R. W. (2012). Recommendations for the use of rituximab in anti-neutrophil cytoplasm antibody-associated vasculitis. Rheumatology, 51(4), 634-643. [ker150]. DOI:10.1093/rheumatology/ker150
    . Publication link: cbcbaaea-46fd-4089-ab41-ab9b3278f5cc | PubMed:21613248
  • Hanly, J. G., Urowitz, M. B., Su, L., Gordon, C., Bae, S. C., Sanchez-Guerrero, J., ... Farewell, V. (2012). Seizure disorders in systemic lupus erythematosus results from an international, prospective, inception cohort study. Annals of the Rheumatic Diseases, 71(9), 1502-1509. DOI:10.1136/annrheumdis-2011-201089
    . Publication link: aaf3f651-1fd6-4756-88b5-987640a64509 | PubMed:22492779
  • Haque, S., Alexander, M. Y., & Bruce, I. N. (2012). Endothelial progenitor cells: A new player in lupus?. Arthritis Research and Therapy, 14(1), [203]. DOI:10.1186/ar3700
    . Publication link: 0f72c6b7-48cb-40f0-ad40-5b104de70987 | PubMed:22356717
  • Harrison, M. J., Ahmad, Y., Haque, S., Dale, N., Teh, L. S., Snowden, N., ... Bruce, I. N. (2012). Construct and criterion validity of the short form-6D utility measure in patients with systemic lupus erythematosus. Journal of Rheumatology, 39(4), 735-742. DOI:10.3899/jrheum.110648
    . Publication link: d920ea95-86fe-45ea-b601-f2d5d497e5be | PubMed:22298908
  • Lahiri, M., Morgan, C., Symmons, D. P. M., & Bruce, I. N. (2012). Modifiable risk factors for RA: Prevention, better than cure?. Rheumatology, 51(3), 499-512. [ker299]. DOI:10.1093/rheumatology/ker299
    . Publication link: aaa674fe-1b7e-46ee-93aa-e3eb84969134 | PubMed:22120459
  • Mercer, L. K., Green, A. C., Galloway, J. B., Davies, R., Lunt, M., Dixon, W. G., ... Klimiuk, P. (2012). The influence of anti-TNF therapy upon incidence of keratinocyte skin cancer in patients with rheumatoid arthritis: Longitudinal results from the British Society for Rheumatology Biologics Register. Annals of the Rheumatic Diseases, 71(6), 869-874. DOI:10.1136/annrheumdis-2011-200622
    . Publication link: a8e8c26f-5e94-4754-8d94-72da383ade87 | PubMed:22241900
  • Mosca, M., Boumpas, D., Bruce, I. N., Cervera, R., Czirjak, L., Dörner, T., ... Van Vollenhoven, R. F. (2012). Treat-to-target in systemic lupus erythematosus: Where are we today?. Clinical and Experimental Rheumatology, 30(4), S112-S115.
    . Publication link: ab15f446-d89d-4bde-9fc4-3cb4e5382518 | PubMed:23072706
  • Petri, M., Orbai, A. M., Alarcõn, G. S., Gordon, C., Merrill, J. T., Fortin, P. R., ... Magder, L. S. (2012). Derivation and validation of the systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus. Arthritis and Rheumatism, 64(8), 2677-2686. DOI:10.1002/art.34473
    . Publication link: ff6af3e3-4400-4140-9741-1d8aac31ec01 | PubMed:22553077
  • Reynolds, J. A., Haque, S., Berry, J. L., Pemberton, P., Teh, L. S., Ho, P., ... Bruce, I. N. (2012). 25-hydroxyvitamin D deficiency is associated with increased aortic stiffness in patients with systemic lupus erythematosus. Rheumatology, 51(3), 544-551. [ker352]. DOI:10.1093/rheumatology/ker352
    . Publication link: b7e97132-31f8-4afa-ba4d-3c35b39888f9 | PubMed:22120462
  • Urowitz, M. B., Gladman, D. D., Ibañez, D., Fortin, P. R., Bae, S. C., Gordon, C., ... Aranow, C. (2012). Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohort. Arthritis Care and Research, 64(1), 132-137. DOI:10.1002/acr.20648
    . Publication link: 5a172969-558c-46b0-85cf-797161e5e76e | PubMed:21954226
  • Yang, H., Craig, D., Epstein, D., Bojke, L., Light, K., Bruce, I. N., ... Woolacott, N. (2012). Golimumab for the treatment of psoriatic arthritis: A NICE single technology appraisal. PharmacoEconomics, 30(4), 257-270. DOI:10.2165/11595920-000000000-00000
    . Publication link: e605af82-9f34-445e-993b-ee8ffc865395 | PubMed:22283690
  • Yee, C. S., Gordon, C., Isenberg, D. A., Griffiths, B., Teh, L. S., Bruce, I. N., ... Farewell, V. T. (2012). The BILAG-2004 systems tally-a novel way of representing the BILAG-2004 index scores longitudinally. Rheumatology, 51(11), 2099-2105. [kes207]. DOI:10.1093/rheumatology/kes207
    . Publication link: 533957bf-a13a-4a2f-a7aa-b3e95a913b11 | PubMed:22908329

2011

  • Almohmedhusain, A., Mirjafari, H., Al-Husain, A., & Bruce, I. N. (2011). Cardiovascular risk factors in inflammatory arthritis. Current Opinion in Lipidology, 22(4), 296-301. DOI:10.1097/MOL.0b013e3283488c50
    . Publication link: 57a3c5ee-112f-4aca-8fdd-f55120b69bd3 | PubMed:21670670
  • Bowes, J., Eyre, S., Flynn, E., Ho, P., Salah, S., Warren, R. B., ... Barton, A. (2011). Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris. Annals of the Rheumatic Diseases, 70(6), 1016-1019. DOI:10.1136/ard.2010.143123
    . Publication link: e3f10b93-c0ce-4b38-b5dd-fbb75b0718d6 | PubMed:21349879
  • Bowes, J., Orozco, G., Flynn, E., Ho, P., Brier, R., Marzo-Ortega, H., ... Barton, A. (2011). Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis. Annals of the Rheumatic Diseases, 70(9), 1641-1644. DOI:10.1136/ard.2011.150102
    . Publication link: 799bedb4-f6ba-433a-9936-77388359c6c6 | PubMed:21623003
  • Hanly, J. G., Urowitz, M. B., Jackson, D., Bae, S. C., Gordon, C., Wallace, D. J., ... Farewell, V. (2011). SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus. Annals of the Rheumatic Diseases, 70(6), 961-967. DOI:10.1136/ard.2010.138792
    . Publication link: 9f6e9e27-a08e-47a3-85d1-f2b57df207ed | PubMed:21342917
  • Hanly, J. G., Urowitz, M. B., Su, L., Bae, S. C., Gordon, C., Clarke, A., ... Merrill, J. T. (2011). Autoantibodies as biomarkers for the prediction of neuropsychiatric events in systemic lupus erythematosus. Annals of the Rheumatic Diseases, 70(10), 1726-1732. DOI:10.1136/ard.2010.148502
    . Publication link: a41d1257-add5-4552-a348-c8bd58f5ab0f | PubMed:21893582
  • Ippolito, A., Wallace, D. J., Gladman, D., Fortin, P. R., Urowitz, M., Werth, V., ... Petri, M. (2011). Autoantibodies in systemic lupus erythematosus: Comparison of historical and current assessment of seropositivity. Lupus, 20(3), 250-255. DOI:10.1177/0961203310385738
    . Publication link: f97bea24-5997-47d1-8e15-306f4355d140 | PubMed:21362750
  • Isenberg, D. A., Allen, E., Farewell, V., D'Cruz, D., Alarcón, G. S., Aranow, C., ... Rahman, A. (2011). An assessment of disease flare in patients with systemic lupus erythematosus: A comparison of BILAG 2004 and the flare version of SELENA. Annals of the Rheumatic Diseases, 70(1), 54-59. DOI:10.1136/ard.2010.132068
    . Publication link: 632e7c12-3ff9-4054-b4ae-71ab7998ff50 | PubMed:20833737
  • Mathen, S., Varghese, S., Crocker, I., Bruce, I. N., & Tower, C. (2011). Systemic lupus erythematosus, regulatory T cells and pregnancy. Expert Review of Clinical Immunology, 7(5), 635-648. DOI:10.1586/eci.11.59
    . Publication link: 799bc866-7368-40d2-b8fc-e7ceaca7d632 | PubMed:21895476
  • Mirjafari, H., Farragher, T. M., Verstappen, S. M. M., Yates, A., Bunn, D., Marshall, T., ... Bruce, I. N. (2011). Seropositivity is associated with insulin resistance in patients with early inflammatory polyarthritis: Results from the Norfolk Arthritis Register (NOAR); an observational study. Arthritis Research and Therapy, R159. DOI:10.1186/ar3476
    . Publication link: 1e576c80-3fbe-4dbf-b569-0b7020f53c60 | PubMed:21959060
  • Newman, W. G., Payne, K., Tricker, K., Roberts, S. A., Fargher, E., Pushpakom, S., ... Ollier, W. E. R. (2011). A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: The TARGET study. Pharmacogenomics, 12(6), 815-826. DOI:10.2217/pgs.11.32
    . Publication link: 123db8fa-3bbf-4420-bfe7-57001a3883d3 | PubMed:21692613
  • Parker, B., Ahmad, Y., Shelmerdine, J., Edlin, H., Yates, A. P., Teh, L. S., & Bruce, I. N. (2011). An analysis of the metabolic syndrome phenotype in systemic lupus erythematosus. Lupus, 20(14), 1459-1465. DOI:10.1177/0961203311416695
    . Publication link: ff64c784-e166-4f2c-8ce9-0debb6dfca8e | PubMed:21893561
  • Rodgers, M., Epstein, D., Bojke, L., Yang, H., Craig, D., Fonseca, T., ... Woolacott, N. (2011). Etanercept, infliximab and adalimumab for the treatment of psoriatic arthritis: A systematic review and economic evaluation. Health Technology Assessment, 15(10), 134. DOI:10.3310/hta15100
    . Publication link: c8ddf0c9-fc63-400e-bee5-c9fb0939127e | PubMed:21333232
  • Scirè, C. A., Verstappen, S. M. M., Mirjafari, H., Bunn, D. K., Lunt, M., Montecucco, C., ... Symmons, D. P. M. (2011). Reduction of long-term disability in inflammatory polyarthritis by early and persistent suppression of joint inflammation: Results from the norfolk arthritis register. Arthritis Care and Research, 63(7), 945-952. DOI:10.1002/acr.20453
    . Publication link: 8620831d-458f-48b2-b6f7-96c5626212fa | PubMed:21337726
  • Verstappen, S. M. M., McCoy, M. J., Roberts, C., Dale, N. E., Hassell, A. B., Symmons, D. P. M., ... Maddison, P. (2011). Disease activity, smoking, and reproductive-related predictors of poor prognosis in patients with very early inflammatory polyarthritis. Journal of Rheumatology, 38(3), 429-433. DOI:10.3899/jrheum.100756
    . Publication link: d7919c81-fcf8-472c-b767-a8eb06b20e3f | PubMed:21123320
  • Vinet, E., Clarke, A. E., Gordon, C., Urowitz, M. B., Hanly, J. G., Pineau, C. A., ... Bernatsky, S. (2011). Decreased live births in women with systemic lupus erythematosus. Arthritis Care and Research, 63(7), 1068-1072. DOI:10.1002/acr.20466
    . Publication link: 5ca338e3-1d12-4fa9-8e2f-0d97a9db5fe3 | PubMed:21425248
  • Yee, C. S., Farewell, V. T., Isenberg, D. A., Griffiths, B., Teh, L. S., Bruce, I. N., ... Gordon, C. (2011). The use of systemic lupus erythematosus disease activity index-2000 to define active disease and minimal clinically meaningful change based on data from a large cohort of systemic lupus erythematosus patients. Rheumatology, 50(5), 982-988. [keq376]. DOI:10.1093/rheumatology/keq376
    . Publication link: e820b006-cce9-4569-a0ff-a5ba42c9d671 | PubMed:21245073
  • Bruce, I. N., & Sharp, C. A. (2011). Efficiency in follow-up immunology testing for patients with connective tissue diseases and vasculitis. Clin Med, 11(6), 632-633.
    . Publication link: 6aaffeab-b50b-4b15-a442-00747040d228

2010

  • Barta, Z., Harrison, M. J., Wangrangsimakul, T., Shelmerdine, J., Teh, L. S., Pattrick, M., ... Bruce, I. N. (2010). Health-related quality of life, smoking and carotid atherosclerosis in white British women with systemic lupus erythematosus. Lupus, 19(3), 231-238. DOI:10.1177/0961203309351032
    . Publication link: 41580a96-56a0-468d-b635-0e83da04524f | PubMed:20007814
  • Bertsias, G. K., Ioannidis, J. P. A., Aringer, M., Bollen, E., Bombardieri, S., Bruce, I. N., ... Boumpas, D. T. (2010). EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: Report of a task force of the EULAR standing committee for clinical affairs. Annals of the Rheumatic Diseases, 69(12), 2074-2082. DOI:10.1136/ard.2010.130476
    . Publication link: d629a291-b960-4c46-8eda-2316c5a83505 | PubMed:20724309
  • Bowes, J., Flynn, E., Ho, P., Aly, B., Morgan, A. W., Marzo-Ortega, H., ... Barton, A. (2010). Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis. Annals of the Rheumatic Diseases, 69(12), 2199-2203. DOI:10.1136/ard.2010.130575
    . Publication link: 7a0d6fc5-f894-44e0-bab4-a5473ebfc8b9 | PubMed:20643763
  • Bruce, I. N. (2010). Re-evaluation of biologic therapies in systemic lupus erythematosus. Current Opinion in Rheumatology, 22(3), 273-277. DOI:10.1097/BOR.0b013e3283374e78
    . Publication link: 489ec774-7c40-457e-8b22-9248e59c4be4 | PubMed:20177385
  • Bruce, I. N., Gordon, C., Merrill, J. T., & Isenberg, D. (2010). Clinical trials in lupus: What have we learned so far?. Rheumatology, 49(6), 1025-1027. [kep462]. DOI:10.1093/rheumatology/kep462
    . Publication link: a0fee174-f12a-4d17-9747-190049892161 | PubMed:20123955
  • Craddock, N., Hurles, M. E., Cardin, N., Pearson, R. D., Plagnol, V., Robson, S., ... Donnelly, P. (2010). Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature, 464(7289), 713-720. DOI:10.1038/nature08979
    . Publication link: b94fb048-f1ee-42d2-b9df-f0a9854d562f | PubMed:20360734
  • Dixon, W. G., Watson, K. D., Lunt, M., Mercer, L. K., Hyrich, K. L., Symmons, D. P. M., ... Coulson, A. (2010). Influence of anti-tumor necrosis factor therapy on cancer incidence in patients with rheumatoid arthritis who have had a prior malignancy: Results from the British Society for Rheumatology Biologics Register. Arthritis Care and Research, 62(6), 755-763. DOI:10.1002/acr.20129
    . Publication link: a6186c6e-ddd9-48df-a3d2-9c105341465b | PubMed:20535785
  • Hanly, J. G., Urowitz, M. B., Su, L., Bae, S. C., Gordon, C., Wallace, D. J., ... Farewell, V. (2010). Prospective analysis of neuropsychiatric events in an international disease inception cohort of patients with systemic lupus erythematosus. Annals of the Rheumatic Diseases, 69(3), 529-535. DOI:10.1136/ard.2008.106351
    . Publication link: 6e114de8-5d5c-4aed-aced-39e8865be3eb
  • Haque, S., Gordon, C., Isenberg, D., Rahman, A., Lanyon, P., Bell, A., ... Bruce, I. N. (2010). Risk factors for clinical coronary heart disease in systemic lupus erythematosus: The Lupus and Atherosclerosis Evaluation of Risk (LASER) study. Journal of Rheumatology, 37(2), 322-329. DOI:10.3899/jrheum.090306
    . Publication link: aa803215-edf1-47ca-931f-71153585f9df | PubMed:19955047
  • Hüffmeier, U., Uebe, S., Ekici, A. B., Bowes, J., Giardina, E., Korendowych, E., ... Reis, A. (2010). CoMon variants at TRAF3IP2 are aSociated with susceptibility to psoriatic arthritis and psoriasis. Nature Genetics, 42(11), 996-999. DOI:10.1038/ng.688
    . Publication link: d8c458d6-2598-4f67-bd46-92a8e53bde7d | PubMed:20953186
  • McElhone, K., Castelino, M., Abbott, J., Bruce, I. N., Ahmad, Y., Shelmerdine, J., ... Teh, L. S. (2010). The LupusQoL and associations with demographics and clinical measurements in patients with systemic lupus erythematosus. Journal of Rheumatology, 37(11), 2273-2279. DOI:10.3899/jrheum.091277
    . Publication link: 6cc9f3e0-f118-4eb1-b15c-c4e979ae0f96 | PubMed:20810500
  • Owen, S. A., Lunt, M., Hider, S. L., Bruce, I. N., Barton, A., & Thomson, W. (2010). Testing pharmacogenetic indices to predict efficacy and toxicity of Methotrexate monotherapy in a rheumatoid arthritis patient cohort.Arthritis and rheumatism, 62(12), 3827-3829. DOI:10.1002/art.27754
    . Publication link: ebdc5374-cd0c-48c6-946a-9bdc64d9e5c4 | PubMed:20848569
  • Parker, B., & Bruce, I. N. (2010). The Metabolic Syndrome in Systemic Lupus Erythematosus. Rheumatic Disease Clinics of North America, 36(1), 81-97. DOI:10.1016/j.rdc.2009.12.004
    . Publication link: 3da76d1a-e569-4d21-a609-4bc540378b8f | PubMed:20202592
  • Urowitz, M. B., Gladman, D., Ibañez, D., Bae, S. C., Sanchez-Guerrero, J., Gordon, C., ... Maddison, P. (2010). Atherosclerotic vascular events in a multinational inception cohort of systemic lupus erythematosus. Arthritis Care and Research, 62(6), 881-887. DOI:10.1002/acr.20122
    . Publication link: 50f39ae3-b7a8-4f61-b268-86de294d6c09 | PubMed:20535799
  • Verstappen, S. M. M., McCoy, M. J., Roberts, C., Dale, N. E., Hassell, A. B., Symmons, D. P. M., ... Maddison, P. (2010). Beneficial effects of a 3-week course of intramuscular glucocorticoid injections in patients with very early inflammatory polyarthritis: Results of the STIVEA trial. Annals of the Rheumatic Diseases, 69(3), 503-509. DOI:10.1136/ard.2009.119149
    . Publication link: dcf63c0a-13eb-43e2-adc9-9814603a1ffb | PubMed:19825849
  • Yee, C. S., Cresswell, L., Farewell, V., Rahman, A., Teh, L. S., Griffiths, B., ... Gordon, C. (2010). Numerical scoring for the BILAG-2004 index. Rheumatology, 49(9), 1665-1669. [keq026]. DOI:10.1093/rheumatology/keq026
    . Publication link: 1918d25f-3157-496f-98bc-9c58a6adea3d | PubMed:20181671

2009

  • Cresswell, L., Yee, C. S., Farewell, V., Rahman, A., Teh, L. S., Griffiths, B., ... Gordon, C. (2009). Numerical scoring for the Classic BILAG index. Rheumatology, 48(12), 1548-1552. DOI:10.1093/rheumatology/kep183
    . Publication link: 39dccf09-528d-4266-a809-3527a42037f7 | PubMed:19779027
  • Hyrich, K. L., Deighton, C., Watson, K. D., Symmons, D. P. M., Lunt, M., Maiden, N., ... Klimiuk, P. (2009). Benefit of anti-TNF therapy in rheumatoid arthritis patients with moderate disease activity. Rheumatology, 48(10), 1323-1327. DOI:10.1093/rheumatology/kep242
    . Publication link: 8419b612-4c20-428d-b5af-b20d90d1e7a6 | PubMed:19706737
  • Nikpour, M., Gladman, D. D., Ibañez, D., Bruce, I. N., Burns, R. J., & Urowitz, M. B. (2009). Myocardial perfusion imaging in assessing risk of coronary events in patients with systemic lupus erythematosus. Journal of Rheumatology, 36(2), 288-294. DOI:10.3899/jrheum.080776
    . Publication link: 5364b2ce-7759-492d-9b1f-677128145df6
  • Pemberton, P. W., Ahmad, Y., Bodill, H., Lokko, D., Hider, S. L., Yates, A. P., ... Bruce, I. N. (2009). Biomarkers of oxidant stress, insulin sensitivity and endothelial activation in rheumatoid arthritis: A cross-sectional study of their association with accelerated atherosclerosis. BMC research notes, 2, [83]. DOI:10.1186/1756-0500-2-83
    . Publication link: 2ca0f606-5fd8-4e3d-8fd1-cbd319ff6e06 | PubMed:19426539
  • Yee, C. S., Farewell, V., Isenberg, D. A., Griffiths, B., Teh, L. S., Bruce, I. N., ... Gordon, C. (2009). The BILAG-2004 index is sensitive to change for assessment of SLE disease activity. Rheumatology, 48(6), 691-695. DOI:10.1093/rheumatology/kep064
    . Publication link: 43e65cbf-b5f3-4641-ae26-46131a248f18

2008

  • Barton, A., Bruce, I. N., Worthington, J., Liu, Y., Helms, C., Liao, W., ... Bowcock, A. (2008). A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease Loci.PLoS Genet, 4 (3). DOI:10.1371/journal.pgen.1000041
    . Publication link: 06486fc1-0f85-4c5d-8c47-76fa02e7b3fb
  • Hanly, J. G., Urowitz, M. B., Siannis, F., Farewell, V., Gordon, C., Bae, S. C., ... Merrill, J. T. (2008). Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis: Results from an international inception cohort study. Arthritis and Rheumatism, 58(3), 843-853. DOI:10.1002/art.23218
    . Publication link: f7c79d85-8dfa-466c-bff6-0bcd9d8873bf
  • Hanly, J. G., Urowitz, M. B., Su, L., Sanchez-Guerrero, J., Bae, S. C., Gordon, C., ... Farewell, V. (2008). Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study. Arthritis Care and Research, 59(5), 721-729. DOI:10.1002/art.23566
    . Publication link: 90bdb193-1742-4a5f-8011-d55eddff5020
  • Haque, S., Mirjafari, H., & Bruce, I. N. (2008). Atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus. Current Opinion in Lipidology, 19(4), 338-343. DOI:10.1097/MOL.0b013e328304b65f
    . Publication link: 8d64cdaa-067a-4c46-a393-64a9347bafd9 | PubMed:18607179
  • Ho, P. Y. P. C., Barton, A., Worthington, J., Plant, D., Griffiths, C. E. M., Young, H. S., ... Bruce, I. N. (2008). Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: Comparison with psoriasis and undifferentiated inflammatory arthritis. Annals of the Rheumatic Diseases, 67(5), 677-682. DOI:10.1136/ard.2007.071399
    . Publication link: b0785510-9c5f-4e3f-82fa-791a0dc940cd
  • Naz, S. M., Farragher, T. M., Bunn, D. K., Symmons, D. P. M., & Bruce, I. N. (2008). The influence of age at symptom onset and length of followup on mortality in patients with recent-onset inflammatory polyarthritis. Arthritis and Rheumatism, 58(4), 985-989. DOI:10.1002/art.23402
    . Publication link: 4b96ebd4-dda7-4b20-8954-96fc2361710d
  • Orlacchio, A., Bruce, I. N., Rahman, P., Kawarai, T., Bernardi, G., St George-Hyslop, P. H., ... Urowitz, M. B. (2008). The apolipoprotein E2 isoform is associated with accelerated onset of Coronary Artery Disease in Systemic Lupus Erythematosus. Medical Science Monitor, 14(5), CR233-CR237.
    . Publication link: ffe7e2f8-9fe6-441e-af3d-620b3ff5e7e9
  • Petri, M., Kasitanon, N., Lee, S. S., Link, K., Magder, L., Bae, S. C., ... Zoma, A. (2008). Systemic lupus international collaborating clinics renal activity/response exercise: Development of a renal activity score and renal response index. Arthritis and Rheumatism, 58(6), 1784-1788. DOI:10.1002/art.23456
    . Publication link: 7ed9404e-77b4-4ded-aa66-3d78ba7597a0
  • Petri, M., Kasitanon, N., Singh, S., Link, K., Magder, L., Bae, S. C., ... Zoma, A. (2008). Systemic lupus international collaborating clinics renal activity/response exercise: Comparison of agreement in rating renal response. Arthritis and Rheumatism, 58(6), 1789-1795. DOI:10.1002/art.23802
    . Publication link: 219daeb2-dff8-46d9-b7cf-186b9866213a
  • Urowitz, M. B., Gladman, D., Ibañez, D., Fortin, P., Sanchez-Guerrero, J., Bae, S., ... Stoll, T. (2008). Accumulation of coronary artery disease risk factors over three years: Data from an international inception cohort. Arthritis Care and Research, 59(2), 176-180. DOI:10.1002/art.23353
    . Publication link: 00a03b53-3651-404f-a1a0-39ef112d5204
  • Yee, C. S., Isenberg, D. A., Prabu, A., Sokoll, K., Teh, L. S., Rahman, A., ... Gordon, C. (2008). BILAG-2004 index captures systemic lupus erythematosus disease activity better than SLEDAI-2000. Annals of the Rheumatic Diseases, 67(6), 873-876. DOI:10.1136/ard.2007.070847
    . Publication link: 7431f82b-49a1-4ab8-be83-af9efc50dd42
  • Ho, P. Y. P. C., Barton, A., Worthington, J., Plant, D., Griffiths, C. E. M., Young, H. S., ... Bruce, I. N. (2008). Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: Comparison with psoriasis and undifferentiated inflammatory arthritis. (Ann Rheum Dis; Vol. 67( 5)). England: Academic Press. DOI:10.1136/ard.2007.071399
    . Publication link: 13250992-ca9b-4082-b4fd-37e58b7565c6

2007

  • Ahmad, Y., Shelmerdine, J., Bodill, H., Lunt, M., Pattrick, M. G., Teh, L. S., ... Bruce, I. N. (2007). Subclinical atherosclerosis in systemic lupus erythematosus (SLE): The relative contribution of classic risk factors and the lupus phenotype. Rheumatology, 46(6), 983-988. DOI:10.1093/rheumatology/kem002
    . Publication link: 4ec5d5bd-d573-4b83-aa0e-04611f12a2bd
  • Bravo Vergel, Y., Hawkins, N. S., Claxton, K., Asseburg, C., Palmer, S., Woolacott, N., ... Sculpher, M. J. (2007). The cost-effectiveness of etanercept and infliximab for the treatment of patients with psoriatic arthritis. Rheumatology, 46(11), 1729-1735. DOI:10.1093/rheumatology/kem221
    . Publication link: 6ea52c7d-36ee-47fd-bd17-1ea190b42064
  • Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Duncanson, A., Kwiatkowski, D. P., ... Hider, S. (2007). Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics, 39(11), 1329-1337. DOI:10.1038/ng.2007.17
    . Publication link: 68149a9e-dc3e-440b-b7ad-605a11625e24
  • Donovan, H., Gilbert, P., Hider, S., John, S., Silman, A., Barton, A., ... Tobin, M. D. (2007). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447(7145), 661-678. DOI:10.1038/nature05911
    . Publication link: 452b3da6-d34c-4f12-961f-eacc47405871
  • Hanly, J. G., Urowitz, M. B., Sanchez-Guerrero, J., Bae, S. C., Gordon, C., Wallace, D. J., ... Farewell, V. (2007). Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: An international inception cohort study. Arthritis and Rheumatism, 56(1), 265-273. DOI:10.1002/art.22305
    . Publication link: d42de352-4aec-482b-aa79-b4ad2c9c845e
  • McElhone, K., Abbott, J., Shelmerdine, J., Bruce, I. N., Ahmad, Y., Gordon, C., ... Teh, L. S. (2007). Development and validation of a disease-specific health-related quality of life measure, the LupusQoL, for adults with systemic lupus erythematosus. Arthritis Care and Research, 57(6), 972-979. DOI:10.1002/art.22881
    . Publication link: 853d68ae-ef42-4929-99b8-19dcf210e51c
  • Payne, K., Newman, W., Fargher, E., Tricker, K., Bruce, I. N., & Ollier, W. E. R. (2007). TPMT testing in rheumatology: Any better than routine monitoring?. Rheumatology, 46(5), 727-729. DOI:10.1093/rheumatology/kel427
    . Publication link: 2ede8cff-5314-4591-9644-d6ee482eb350
  • Urowitz, M. B., Gladman, D., Ibañez, D., Fortin, P., Sanchez-Guerrero, J., Bae, S., ... Buyon, J. (2007). Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: Data from an international inception cohort. Lupus, 16(9), 731-735. DOI:10.1177/0961203307081113
    . Publication link: 9f861397-9f37-4032-a556-2e3aedf7fb2c
  • Xanthopoulos, E., Hutchinson, C. E., Adams, J. E., Bruce, I. N., Nash, A. F. P., Holmes, A. P., ... Waterton, J. C. (2007). Improved wrist pannus volume measurement from contrast-enhanced MRI in rheumatoid arthritis using shuffle transform. Magnetic Resonance Imaging, 25(1), 110-116. DOI:10.1016/j.mri.2006.10.018
    . Publication link: eccc023b-7771-456a-a9be-9cbdb89e7554 | PubMed:17222722
  • Yee, C. S., Farewell, V., Isenberg, D. A., Rahman, A., Teh, L. S., Griffiths, B., ... Gordon, C. (2007). British Isles Lupus Assessment Group 2004 index is valid for assessment of disease activity in systemic lupus erythematosus. Arthritis and Rheumatism, 56(12), 4113-4119. DOI:10.1002/art.23130
    . Publication link: 8e94395d-eb58-46e7-a367-52866df5a5d4

2006

  • Bruce, I. (2006). Etanercept and infliximab for the treatment of psoriatic arthritis: a systematic review. Clinical and Experimental Rheumatology, 24, 5.
    . Publication link: 6b2998fd-586c-469e-9491-c20bcc5e2680
  • Bruce, I. N., Woolacott, N., Bravo Vergel, Y., Hawkins, N., Kainth, A., Khadjesari, Z., ... Riemsma, R. (2006). Etanercept and infliximab for the treatment of psoriatic arthritis: a systematic review and economic evaluation.Health Technol Assess, 10( 31).
    . Publication link: 5a4f027d-8667-4869-8617-9ede240eb048
  • Bruce, I., Brenchley, P. E. C., Jackson, M., Ahmad, Y., Bruce, I. N., & Coupes, B. (2006). Activation of transforming growth factor-beta1 and early atherosclerosis in systemic lupus erythematosus.Arthritis Res Ther, 8( 3).
    . Publication link: 9e2dd094-c75d-4972-916c-4223772ce196
  • Farragher, T. M., & Bruce, I. N. (2006). Cardiovascular risk in inflammatory rheumatic diseases: Loose ends and common threads. Journal of Rheumatology, 33(11), 2105-2107.
    . Publication link: a79eb83c-3c94-4b6b-8847-a4ebdb560a08
  • Hider, S. L., Owen, A., Hartkoorn, R., Khoo, S., Back, D., Silman, A. J., & Bruce, I. N. (2006). Down regulation of multidrug resistance protein-1 expression in patients with early rheumatoid arthritis exposed to methotrexate as a first disease-modifying antirheumatic drug. Annals of the Rheumatic Diseases, 65(10), 1390-1393. DOI:10.1136/ard.2005.049189
    . Publication link: fc08efeb-c598-4a90-ba66-3b4f1c96f410
  • Patel, M., Clarke, A. M., Bruce, I. N., & Symmons, D. P. M. (2006). The prevalence and incidence of biopsy-proven lupus nephritis in the UK: Evidence of an ethnic gradient. Arthritis and Rheumatism, 54(9), 2963-2969. DOI:10.1002/art.22079
    . Publication link: d792793b-24b7-42c1-b1f1-559b2a55b1d2
  • Yee, C. S., Farewell, V., Isenberg, D. A., Prabu, A., Sokoll, K., Teh, L. S., ... Gordon, C. (2006). Revised British isles lupus assessment group 2004 index: A reliable tool for assessment of systemic lupus erythematosus activity. Arthritis and Rheumatism, 54(10), 3300-3305. DOI:10.1002/art.22162
    . Publication link: 336e3ddf-4979-4630-b57f-195f407507d8

2005

  • Hinks, A., Barton, A., John, S., Bruce, I., Hawkins, C., Griffiths, C. E. M., ... Worthington, J. (2005). Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: Further support that PTPN22 is an autoimmunity gene. Arthritis and Rheumatism, 52(6), 1694-1699. DOI:10.1002/art.21049
    . Publication link: e8b09096-1166-4032-9ba5-95a207fa1bff
  • Ho, P., Bruce, I. N., Silman, A., Symmons, D., Newman, B., Young, H., ... Barton, A. (2005). Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis. Arthritis and Rheumatism, 52(11), 3596-3602. DOI:10.1002/art.21393
    . Publication link: af385c21-9987-4acd-a736-3ee4adf15f1b
  • Isenberg, D. A., Rahman, A., Allen, E., Farewell, V., Akil, M., Bruce, I. N., ... Gordon, C. (2005). BILAG 2004. Development and initial validation of an updated version of the British Isles Lupus Assessment Group's disease activity index for patients with systemic lupus erythematosus. Rheumatology, 44(7), 902-906. DOI:10.1093/rheumatology/keh624
    . Publication link: 2e1a5613-671f-47b3-9c12-86c5335ee16b
  • Urowitz, M. B., Feletar, M., Bruce, I. N., Ibañez, D., & Gladman, D. D. (2005). Prolonged remission in systemic lupus erythematosus. Journal of Rheumatology, 32(8), 1467-1472.
    . Publication link: 25b0225e-c04c-403a-91b8-d5bc8ddb0dbe

2003

  • Bruce, I. N., Gladman, D. D., Ibañez, D., & Urowitz, M. B. (2003). Single photon emission computed tomography dual isotope myocardial perfusion imaging in women with systemic lupus erythematosus. II. Predictive factors for perfusion abnormalities. Journal of Rheumatology, 30(2), 288-291.
    . Publication link: 587f1d78-96c3-48fa-981f-7a1bae05b84c
  • Bruce, I. N., Urowitz, M. B., Gladman, D. D., Ibañez, D., & Steiner, G. (2003). Risk Factors for Coronary Heart Disease in Women With Systemic Lupus Erythematosus: The Toronto Risk Factor Study. Arthritis and Rheumatism, 48(11), 3159-3167. DOI:10.1002/art.11296
    . Publication link: d7b12fea-48cc-498c-a4ea-e640441ebfd1
  • Kerr, J. R., Cunniffe, V. S., Kelleher, P., Bernstein, R. M., & Bruce, I. N. (2003). Successful intravenous immunoglobulin therapy in 3 cases of parvovirus B19-associated chronic fatigue syndrome.Clinical Infectious Diseases, 36(9), e100-106. DOI:10.1086/374666
    . Publication link: 08ba9ec7-3143-4409-afa2-bccc2c2c94ef
  • Morgan, C., Lunt, M., Brightwell, H., Bradburn, P., Fallow, W., Lay, M., ... Bruce, I. N. (2003). Contribution of patient related differences to multidrug resistance in rheumatoid arthritis. Annals of the Rheumatic Diseases, 62(1), 15-19. DOI:10.1136/ard.62.1.15
    . Publication link: e9394e90-3a62-4320-870b-cca3e154f3ab

2002

  • Harrison, B. J., Hutchinson, C. E., Adams, J., Bruce, I. N., & Herrick, A. L. (2002). Assessing periarticular bone mineral density in patients with early psoriatic arthritis or rheumatoid arthritis. Annals of the Rheumatic Diseases, 61(11), 1007-1011. DOI:10.1136/ard.61.11.1007
    . Publication link: 5c221fad-06c7-4c05-b29a-d9741e259a91
  • Kerr, J. R., Bracewell, J., Laing, I., Mattey, D. L., Bernstein, R. M., Bruce, I. N., & Tyrrell, D. A. J. (2002). Chronic fatigue syndrome and arthralgia following parvovirus B19 infection. Journal of Rheumatology, 29(3), 595-602.
    . Publication link: f3666630-79d3-4b70-98b2-49ff8925db76
  • Mahmood, S., Suresh, P. S., Carley, F., Bruce, I. N., & Tullo, A. B. (2002). Surgically induced necrotising scleritis: Report of a case presenting 51 years following strabismus surgery [8]. Eye, 16(4), 503-504. DOI:10.1038/sj.eye.6700033
    . Publication link: 5a5b97a3-033c-4c50-bee6-c94efd2db8f1

2001

  • Barton, A. C., Bruce, I. N., & Silman, A. J. (2001). Genetic studies of psoriatic arthritis: Dissecting joints and skin. Journal of Rheumatology, 28(1), 3-5.
    . Publication link: 3d2ac024-3443-4ad5-9145-c20113f2c586
  • El-Magadmi, M., Alansari, A., Teh, L. S., Ordi, J., Gül, A., Inanc, M., ... Hajeer, A. (2001). Association of the A561C E-selectin polymorphism with systemic lupus erythematosus in 2 independent populations. Journal of Rheumatology, 28(12), 2650-2652.
    . Publication link: 9e1c4679-670e-4871-ad71-cd85d7fe72aa

2000

  • Bruce, I. (2000). Prevalence of antibodies to beta2-glycoprotein I in systemic lupus erythematosus and their association with antiphospholipid antibody syndrome criteria: a single center study and literature review. Journal of Rheumatology, 27, 12.
    . Publication link: 4964aa76-6b81-471c-b455-864a2e7aa4bd
  • Bruce, I. N., Burns, R. J., Gladman, D. D., & Urowitz, M. B. (2000). Single photon emission computed tomography dual isotope myocardial perfusion imaging in women with systemic lupus erythematosus. I. Prevalence and distribution of abnormalities. Journal of Rheumatology, 27(10), 2372-2377.
    . Publication link: f0223752-4d23-4148-bcee-d0fa0dccafb5

1999

  • Bruce, I. N., Hallett, D. C., Gladman, D. D., & Urowitz, M. B. (1999). Extrarenal disease activity in systemic lupus erythematosus is not suppressed by chronic renal insufficiency or renal replacement therapy. Journal of Rheumatology, 26(7), 1490-1494.
    . Publication link: ff340fce-d92d-40c3-b78c-32a566eb351f
  • Bruce, I. N., Mak, V. C., Hallett, D. C., Gladman, D. D., & Urowitz, M. B. (1999). Factors associated with fatigue in patients with systemic lupus erythematosus. Annals of the Rheumatic Diseases, 58(6), 379-381.
    . Publication link: 400d3f86-c6c7-4ddf-999d-2bc1683459c2

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