The Manchester Fungal Infection Group (MFIG) is a new international centre of excellence for fungal infection biology and translational antifungal research at the University of Manchester. It is integrating its research with that of clinicians and industry.
To understand and reduce the burden of human fungal diseases
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(Image : Asexual structures of Apergillus niger)
Using the human pathogen Aspergillus fumigatus as our main experimental system, MFIG’s research is focused on four integrated themes:
Fungal cell biology, Host-pathogen interactions, Genetics and genomics and Antifungal drug discovery
Learn more about us in our downloadable MFIG booklet
- Professor Nick D Read (Director)
Cell biology of colony initiation and infection; fungal calcium signalling; antifungal peptides
- Dr Elaine Bignell (Deputy Director)
Host-pathogen interactions; pH sensing
- Dr Paul Bowyer
Genomics and genetics; antifungal resistance
- Dr Mike Bromley
Antifungal drug discovery; high throughput gene deletion and library screening
MFIG in the Scientific Community:
- MFIG was officially opened by Professor Sir Robert Boyd on the 9th Sept 2015
- MRC funding for network biology of the pathogenic mould Aspergillus fumigatus
- MFIG secures second 2015 Marie Curie Research Fellow Dr Jorge Amicg (starting January 2016)
- Manchester researchers call for antifungal drug boost. Published in Science (27 March), Dr Mike Bromley andf Prof David Denning highlight the current problems for doctors: poor responses, antifungal rsistance, drugs interaction and toxicity to many of the existing drugs.
- MFIG secures BBSRC-DTG PhD scholarship with UoM Masters Student, Norman van Rhijn.
- Prof Nick Read has been elected as the President of the British Mycological Society (BMS) for the period 2015-2016.
- Dr Elaine Bignell secures BBSRC-iCASE studentship with Blueberry Therapeutics commencing Oct 2015.
- Dr Margherita Bertuzzi will be presenting a talk entitled "Mould pathogenesis in the mammalian lung" at the next Faculty Research Series on the 18th March 2015. For registration click here.
Press Releases :
- Fungicides for crops: worrying link to fungal drug resistance in UK warn scientists
- MFIG welcomes Professor Michelle Momany (University of Georgia) to Manchester on a Royal Society-funded Exchange Scheme (Momany/Bignell).
- Elaine Bignell presented an overview of A. fumigatus pathogenicity at Pfizer Global R&D (Vaccine Development), Pearl River, New Jersey, USA.
In silico modeling of spore inhalation reveals fungal persistence following low dose exposure. Tanaka et al, 2015, Scientific Reports
How to bolster the antifungal pipeline, Denning and Bromley, 2015, Science
The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial invasion during pulmonary aspergillosis, Bertuzzi et al, 2014, PLoS Pathog
The Janus transcription factor HapX controls fungal adaptation to both iron starvation and iron excess, Gsaller et al, 2014, EMBO J
Clinical implications of interferon gamma genetic and epigenetic variants, Smith and Denning 2014, Immunology (online review article)
Occurrence of azole-resistant species of Aspergillus in the UK environment, Bromley et al, 2014, J Glob Antimicrob Resist